# Isntree C-Niacin Toning Ampoule for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: Superior · Effectiveness: Superior · Safety: High.

Page: https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Isntree](https://lovi.care/skincare/nl/brands/isntree)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your dry and sensitive skin is provided by humectants like Glycerin and Sodium Hyaluronate, complemented by soothing agents such as Aloe Barbadensis Leaf Extract and Allantoin, which hydrate and calm irritation.
- The high concentrations of 3-O-Ethyl Ascorbic Acid and Niacinamide offer significant brightening and evening of skin tone, addressing your concerns for dry or flaky skin.
- The product is safe for your skin, featuring a gentle formulation with no harsh ingredients and beneficial soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin): Superior

## Key ingredients

Niacinamide, 3-O-Ethyl Ascorbic Acid Ascorbic Acid, Hippophae Rhamnoides Fruit Extract, Sodium Hyaluronate, Aloe Barbadensis Leaf Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of a sea buckthorn fruit extract formulation significantly reduced skin sebum secretion in 10 healthy human volunteers compared to the control base over an 8-week period. ([Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/))
- Topical emulsions containing Hippophae rhamnoides and Cassia fistula plant extracts significantly reduced skin sebum contents compared to placebo in patients with grade I and grade II acne vulgaris. ([Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/))
- Topical application of a 5% Hippophae rhamnoides oil-in-water emulsion significantly improved skin hydration (p=0.0003) and transepidermal water loss (p=0.0087) compared to a placebo base formulation in 13 healthy male subjects over 84 days. ([Pakistan Journal of Pharmaceutical Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25362595/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))

## What reviewers say

This ampoule is frequently praised for its lightweight, fast-absorbing texture and its ability to gently brighten the skin, providing a natural glow. It is well-tolerated by sensitive and acne-prone skin types. Some users report that results are subtle and require consistent long-term use, with a few experiencing minor breakouts or noting the watery consistency can be difficult to handle.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Brightens and glows (often mentioned)
- Liked: Gentle on sensitive skin (often mentioned)
- Liked: Hydrating (sometimes noted)
- Disliked: Slow or minimal results (sometimes noted)
- Disliked: Minor breakouts (rarely noted)
- Disliked: Runny consistency (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Isntree C-Niacin Toning Ampoule a great fit for dry sensitive skin?

This product is a great fit because it uses hydrating ingredients like glycerin and sodium hyaluronate alongside calming aloe vera and allantoin to keep your dry and sensitive skin soft and comfortable. It also contains vitamin C and niacinamide to help brighten your skin tone and address flaky areas without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Glycerin and Sodium Hyaluronate provide excellent suitability for your skin by drawing in moisture, while Aloe Barbadensis Leaf Extract and Allantoin help calm irritation. Niacinamide and 3-O-Ethyl Ascorbic Acid also help brighten your skin tone safely and gently.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for dry sensitive skin?

Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/23220080/)

### What does 3-O-Ethyl Ascorbic Acid do for dry sensitive skin?

3-O-Ethyl Ascorbic Acid helps brighten an uneven skin tone and fights signs of aging, but for dry sensitive skin it may need extra moisturizing ingredients like dexpanthenol to keep skin calm, soft, and smooth.
Sources: [Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38794349/), [Journal of Cosmetic Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/23174055/)

### Where does it go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after your soothing toner and before your moisturizer. Putting it in the evening keeps things simple and helps avoid any extra sensitivity around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first, letting it absorb, and following with your retinol. Because this product contains gentle soothing ingredients and hydrators like glycerin and sodium hyaluronate, it helps calm irritation and keeps dry sensitive skin comfortable while you use retinol.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use it?

This product is a great fit for your dry sensitive skin, and you can use it in your evening routine as suggested by the routine guide. Hydrating ingredients like glycerin and sodium hyaluronate help keep your skin comfortable and smooth while brightening the tone.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for dry sensitive skin, as it features a gentle formulation with soothing ingredients and low complaints of minor breakouts. Reviewers mention only negligible tackiness, and the product is considered safe for your skin type.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — €160.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — €10.20 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/nl/p/augustinus-bader/the-serum/for/dry-sensitive-skin) — Superior fit — €474.90 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/nl/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €15.00 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/nl/p/skin1004/centella-asiatica-toning-toner/for/dry-sensitive-skin) — Superior fit — €17.96 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/nl/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €16.75 at Amazon

## Where to buy

- Notino: €15.50 (https://www.notino.nl/isntree/c-niacin-herstellende-en-verhelderende-serum/p-16116554/)
Prices checked 10 Oct 2026.

## Ingredients

Hippophae Rhamnoides Fruit Extract, Butylene Glycol, Pentylene Glycol, Glycerin, Betaine, Water, Niacinamide, Propanediol, Aloe Barbadensis Leaf Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Pumpkin Fruit Extract, Physalis Alkekengi Fruit Extract, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Ocimum Sanctum Leaf Extract, Beta-Glucan, Curcuma Longa Root Extract, Corallina Officinalis Extract, Brassica Oleracea Italica Extract, Coccinia Indica Fruit Extract, Moringa Oleifera Seed Oil, Boswellia Serrata Extract Resin, Bioflavonoids, Panthenol, Allantoin, Sodium Polyacrylate, Tocopherol, Polysorbate 80, 1,2-Hexanediol, Ethyl Hexanediol, Ammonium Acryloyldimethyltaurate Vp Copolymer, 3-O-Ethyl Ascorbic Acid, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin (this page)
- Spain: https://lovi.care/skincare/es/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin