# iS Clinical Brightening Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [iS Clinical](https://lovi.care/skincare/nl/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate brightening for your combination skin, as alpha-arbutin and saccharum officinarum extract work to even skin tone, while willow bark extract and glycerin provide mild exfoliation and hydration.
- While it offers general skincare benefits, it lacks specialized ingredients to directly address your oily shine.
- The formula is generally safe for your combination skin, though alcohol denat and menthol may pose a slight risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Alpha-Arbutin, Ascophyllum Nodosum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Willow Bark Extract, Saccharum Officinarum Extract

## What the research says

- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical 30% l-menthol decreased cold pain thresholds and enhanced pain responses to suprathreshold noxious cold stimuli without affecting other stimuli in 39 healthy subjects compared to ethanol control. ([Pain, 2006](https://pubmed.ncbi.nlm.nih.gov/16527405/))
- Cooling skin temperature or applying topical menthol reduced histamine-induced itch intensity and flare diameters in healthy male volunteers. ([Neuroscience Letters, 1995](https://pubmed.ncbi.nlm.nih.gov/7624016/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- A novel emulsion containing niacinamide, lens esculenta seed extract, and white willow bark extract effectively improved acne, blackheads, and conspicuous facial pores in 30 subjects with oily skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38140770/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))

## Why other serums fit combination skin better

- Topical menthol induced significant pain, cold sensations, punctate and cold hyperalgesia, and increased cutaneous perfusion in 10 subjects compared to ethanol control, acting as a human model for cold pain by sensitizing peripheral cold C nociceptors and activating cold-specific A delta fibres. ([Brain, 2004](https://pubmed.ncbi.nlm.nih.gov/14985268/))
- Topical menthol strongly activates and sensitizes Type 2 C fibres to cooling, which also respond to heating and continue to discharge down to 0 degrees C, potentially accounting for paradoxical thermal sensations and neuropathic pain. ([The Journal of Physiology, 2009](https://pubmed.ncbi.nlm.nih.gov/19822550/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

This review data is based on limited data. Users frequently report visible improvements in dark spots, skin radiance, and overall texture, noting that the formula is generally gentle enough for various skin types, including sensitive skin. Some users may find it less effective for stubborn conditions or notice potential irritation if used too frequently.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Evens skin tone (often mentioned)
- Liked: Gentle formula (sometimes noted)
- Liked: Improves texture (sometimes noted)
- Disliked: Slow/no results (sometimes noted)
- Disliked: Potential breakouts (rarely noted)
- Disliked: Price point (rarely noted)
- Disliked: Tingling sensation (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does iS Clinical Brightening Serum work for combination skin?

iS Clinical Brightening Serum works moderately well for combination skin by evening skin tone with alpha-arbutin, while providing mild exfoliation and hydration through willow bark extract and glycerin. However, it lacks specialized ingredients to control oily shine, and alcohol denat and menthol may cause slight irritation. Treatments for combination skin work best when they include ingredients like niacinamide, zinc PCA, or propolis to regulate oiliness and enhance radiance without irritation.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### Which ingredients make this serum a good fit for combination skin?

Alpha-arbutin and saccharum officinarum extract in this serum even your skin tone, while willow bark extract and glycerin provide mild exfoliation and hydration for combination skin. To work best for this skin type, a product of this type needs ingredients like niacinamide, zinc PCA, and propolis to control oily shine and boost radiance without any risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### What does Alpha-Arbutin do for combination skin?

Alpha-arbutin helps fade dark spots and even out skin tone for combination skin. It works safely to brighten areas with extra pigment while helping to keep the face looking smooth and clear.
Sources: [Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39555866/)

### What does Ascophyllum Nodosum Extract do for combination skin?

Ascophyllum Nodosum Extract helps keep combination skin calm and balanced while protecting sensitive areas. This marine ingredient is often included in gentle face care products to support a smooth, even texture.
Sources: [Marine Drugs, 2021](https://pubmed.ncbi.nlm.nih.gov/34436303/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. Combination skin of this type needs a treatment with ingredients that help balance oil and shine.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol product. Because this formula contains ingredients that may cause irritation, alternating nights or monitoring your skin closely helps prevent discomfort.

### How often should I use this serum?

This treatment should be used once a week in the evening to start, as combination skin needs gentle introduction for exfoliating ingredients like willow bark extract. If your skin tolerates it well without irritation from the alcohol denat and menthol, you may carefully use it more often. Combination skin of this type also needs oil-controlling ingredients to properly manage oily shine.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for combination skin, though a small number of reviewers report low potential for breakouts. It lacks specialized ingredients to directly address oily shine and manage congestion, which a product of this type needs for this skin.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €35.80 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/nl/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €474.90 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/nl/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €16.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/combination-skin) — Superior fit — €19.20 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Butylene Glycol, Water, Glycerin, Alcohol Denat, Ascophyllum Nodosum Extract, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Alpha-Arbutin, Glyceryl Polyacrylate, Polyporus Umbellatus Extract Mushroom Extract, Willow Bark Extract, Menthol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/brightening-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/brightening-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/brightening-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/brightening-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/brightening-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/brightening-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/brightening-serum/for/combination-skin (this page)
- Spain: https://lovi.care/skincare/es/p/is-clinical/brightening-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/brightening-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/brightening-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/brightening-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/brightening-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/brightening-serum/for/combination-skin