# IOPE PDRN Caffeine Shot Serum for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [IOPE](https://lovi.care/skincare/nl/brands/iope)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your dry and flaky skin, as glycerin and beta-glucan provide essential hydration and barrier support. Niacinamide and caffeine also contribute to energizing and improving skin tone, aligning with general skincare needs.
- The formulation is highly suitable for dry skin due to the humectant action of glycerin and barrier repair from beta-glucan.
- The product is safe for your dry and sensitive skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Bio-Pdrn, Caffeine, Niacinamide, Adenosine, Lactobacillus Lysate Ferment

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks. ([International Journal of Cosmetic Science, 2011](https://pubmed.ncbi.nlm.nih.gov/21564138/))
- Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects. ([Frontiers in Physiology, 2019](https://pubmed.ncbi.nlm.nih.gov/31130869/))
- Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid. ([AAPS PharmSciTech, 2021](https://pubmed.ncbi.nlm.nih.gov/33796955/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials. ([Current Issues in Molecular Biology, 2022](https://pubmed.ncbi.nlm.nih.gov/35723322/))

## What reviewers say

Based on a very large amount of data, users consistently praise this serum for its lightweight, fast-absorbing texture and its ability to visibly reduce facial puffiness and refine skin texture. While highly effective for "de-puffing" and strengthening the moisture barrier, some users with very dry skin find it requires an additional moisturizer, and the high price point is a frequent point of contention.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Reduces puffiness (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Liked: Improves skin barrier (sometimes noted)
- Disliked: Dry skin needs more (sometimes noted)
- Disliked: Minor breakouts (rarely noted)
- Disliked: Subtle anti-aging (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does IOPE PDRN Caffeine Shot work for dry sensitive skin?

IOPE PDRN Caffeine Shot Serum works moderately well for dry sensitive skin, providing essential hydration and barrier support through glycerin and beta-glucan while improving skin tone with niacinamide and caffeine. To fit this skin type even better, a treatment of this type needs rich moisturizing ingredients like ceramides and vitamin C to deliver maximum hydration, improve texture, and enhance resilience against environmental stressors.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Glycerin and beta-glucan make this serum a good fit by providing essential hydration and barrier support for dry skin. A product of this type needs maximum beneficial ingredients that deeply hydrate and protect, along with ceramides and multiple forms of vitamin C to enhance skin resilience.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Bio-PDRN do for dry sensitive skin?

Bio-PDRN helps calm dry sensitive skin while supporting skin healing and barrier strength. It may improve skin texture and moisture without causing irritation, making it a gentle option for skin that is easily upset.
Sources: [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35587098/), [Regenerative Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32757710/)

### What does Caffeine do for dry sensitive skin?

Caffeine helps wake up tired skin and reduces puffiness by boosting microcirculation, while also protecting delicate areas with antioxidants. Because sensitive skin can react easily, it is generally well tolerated when paired with soothing ingredients to keep the skin calm and comfortable.
Sources: [Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23075568/), [Frontiers in Physiology, 2019](https://pubmed.ncbi.nlm.nih.gov/31130869/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after your soothing toner and before your moisturizer. Putting it in the evening helps keep your routine simple and adds extra safety around sun exposure. To get a better fit for dry and sensitive skin, this type of product needs rich soothing ingredients like ceramides, plant oils, and extra glycerin to deeply soften flaky skin.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to deliver gentle hydration and barrier support, followed by your retinol. This product is unlikely to irritate dry, sensitive skin due to the absence of harsh ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this serum in your evening routine, applying it after your toner and before your moisturizer. To best care for dry sensitive skin, a product of this type needs rich hydration and barrier support from ingredients like glycerin and beta-glucan.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to cause breakouts or clog pores on dry sensitive skin, as it has a very low risk of irritation and reviewers rarely mention minor breakouts. However, dry skin often needs richer hydration and barrier support from heavier creams and oils to truly feel soft and smooth.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — €160.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — €10.20 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/nl/p/augustinus-bader/the-serum/for/dry-sensitive-skin) — Superior fit — €474.90 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/nl/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €15.00 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/nl/p/skin1004/centella-asiatica-toning-toner/for/dry-sensitive-skin) — Superior fit — €17.96 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/nl/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €16.75 at Amazon

## Where to buy

- Amazon.nl: €55.70 (https://www.amazon.nl/dp/B0BJQ86VNH?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Lactobacillus Lysate Ferment, Water, Propanediol, Glycerin, Niacinamide, Butylene Glycol, Caffeine, Dipropylene Glycol, 2-Hexanediol, Diethoxyethyl Succinate, Glyceryl Polymethacrylate, Polyacrylate Crosspolymer-6, Mannitol, Ethylhexylglycerin, Adenosine, Sodium Citrate, Dextrin, Theobroma Cacao Extract, Citric Acid, Disodium Edta, T-Butyl Alcohol, Arginine, Cyclodextrin, Hydroxypropyl Cyclodextrin, Maltodextrin, Xanthan Gum, Beta-Glucan, Acetyl Tetrapeptide-11, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin (this page)
- Spain: https://lovi.care/skincare/es/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/iope/pdrn-caffeine-shot-serum/for/dry-sensitive-skin