# glymed+ Oxygen Cream for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [glymed+](https://lovi.care/skincare/nl/brands/glymed)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Suitable for normal skin, this product provides excellent moisturization with glycerin and Tropaeolum Majus Stem Extract to hydrate and enhance barrier resilience.
- While it offers general skincare benefits like hydration from ingredients such as Tocopheryl Acetate, these are mostly supportive and not directly targeted at addressing your concerns with wrinkles and fine lines.
- The product is safe for your normal skin, as it lacks prohibited or harsh ingredients and carries no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Hydrolyzed Candida Saitoana Extract, Lactobacillus Wasabia Extract, Tetrahexyldecyl Ascorbate, Glycerin, Tocopheryl Acetate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Co-encapsulation of alpha-tocopherol and alpha-tocopheryl acetate in nanostructured lipid carrier gel formulations significantly enhanced moisture retention up to 68% and improved skin elasticity in human volunteers compared to a solution gel. ([Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/))
- Vitamin E in O/W and W/O emulsions significantly increased stratum corneum hydration and enhanced water-binding capacity, with an optimum concentration of 5%. ([Arzneimittel-Forschung, 1998](https://pubmed.ncbi.nlm.nih.gov/9706379/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Isosaponarin isolated from wasabi leaf increased type I collagen production in human fibroblasts by up-regulating TbetaR-II and P4H expression. ([Journal of Natural Medicines, 2010](https://pubmed.ncbi.nlm.nih.gov/20349148/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))

## Why other moisturizers fit mature skin better

- Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement. ([Nanomaterials, 2024](https://pubmed.ncbi.nlm.nih.gov/38668218/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Topical cream containing saffron extract and avocado oil improved wrinkle grading, reduced nasolabial fold area and volume, and increased skin elasticity in twenty healthy volunteers over 12 weeks without allergic reactions. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31957954/))

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does GlyMed Plus Oxygen Cream work for mature skin?

GlyMed Plus Oxygen Cream works reasonably well for mature skin by providing good hydration and support, though other products target wrinkles and fine lines more directly. To fit mature skin best, a moisturizing treatment needs potent anti-aging ingredients like peptides, antioxidants, and rich hydrating components that smooth fine lines while maintaining the skin's moisture balance.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for mature skin?

Glycerin and Tocopheryl Acetate make this cream a good fit for mature skin by helping with hydration and barrier resilience. To best care for mature skin, a moisturizing treatment of this type needs potent ingredients that address wrinkles and fine lines, along with nourishing antioxidants and peptides.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hydrolyzed Candida Saitoana Extract do for mature skin?

Hydrolyzed Candida Saitoana Extract helps mature skin by supporting natural cellular renewal processes that keep skin looking youthful and smooth. This ingredient encourages the clearing of damaged cellular components, which helps protect against signs of aging and keeps skin firm and soft.

### What does Lactobacillus Wasabia Extract do for mature skin?

Lactobacillus Wasabia Extract is unlikely to provide the specialized firming and collagen support that mature skin needs. Skin of this type benefits most from ingredients like peptides and retinol to help smooth fine lines and maintain a firm feel.

### Where does this cream go in a skincare routine for mature skin?

Apply this moisturizing treatment as the moisturizer step in your morning routine and evening routine. To best care for mature skin, a product of this type needs firming peptides and concentrated antioxidants that directly target wrinkles and fine lines.

### Can I use this cream with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying it after your retinol product to help keep your skin comfortable and hydrated. Using a supportive moisturizer with barrier-enhancing ingredients is well-established to help reduce dryness and irritation when starting strong anti-aging routines.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice a day as part of your morning and evening routine to keep your skin hydrated and soft. Using it regularly helps maintain moisture and supports your skin barrier safely without irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

Glymed+ Oxygen Cream is unlikely to clog pores or cause breakouts for mature skin because it lacks harsh ingredients and carries no risk of irritation. A product of this type needs antioxidant ingredients like vitamin C and retinol, alongside peptides, to effectively smooth fine lines and firm mature skin.
Sources: [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### Can I use this cream around the eyes or on my body?

You can safely use this moisturizing treatment on your body and around the eyes, as it features a gentle formula that is unlikely to cause irritation. Because mature skin needs targeted care for wrinkles and fine lines, this type of product works best when it includes specialized anti-aging ingredients like retinol, peptides, or concentrated antioxidants.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/nl/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €69.99 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/nl/p/the-ordinary/natural-moisturizing-factors-ha/for/mature-skin) — High fit — €13.02 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Cream](https://lovi.care/skincare/nl/p/missha/super-aqua-ultra-hyalron-cream/for/mature-skin) — High fit — €39.42 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €14.70 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Isodecyl Neopentanoate, Isononyl Isononanoate, Glycerin, Tropaeolum Majus Stem Extract, Polyacrylate Crosspolymer-6, Hydroxystearyl Glucoside, Hydrolyzed Candida Saitoana Extract, Sorbitol, Lactobacillus Wasabia Extract, Sake Extract, Tocopheryl Acetate, Tetrahexyldecyl Ascorbate, Hydroxystearyl Alcohol, Grapefruit Peel Oil, Sodium Phytate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/glymed/oxygen-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/glymed/oxygen-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/glymed/oxygen-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/glymed/oxygen-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/glymed/oxygen-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/glymed/oxygen-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/glymed/oxygen-cream/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/glymed/oxygen-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/glymed/oxygen-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/glymed/oxygen-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/glymed/oxygen-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/glymed/oxygen-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/glymed/oxygen-cream/for/mature-skin