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Eighth Day Regenerative Serum for sensitive skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Eighth Day Regenerative Serum

Average

  • HighNormal Skin Fit
  • AverageEffectiveness
  • Low RiskSafety

Works for sensitive skin; other serums fit it better.

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate benefits for normal skin, as Peptide-Rich Plasma and Sodium Hyaluronate support barrier repair and hydration, but the multiple peptides are not specialized for your redness and irritation concerns.
  • Sea Whip Extract and Allantoin provide some soothing effects, though stronger anti-inflammatory ingredients would better address your specific issues.
  • The formula is generally safe for sensitive skin, with Glycolic Acid posing a slight risk of irritation.

How to apply

  • Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
  • Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
  • Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
  • Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
  • Always do a patch test before your first use and avoid getting the serum too close to your eyes .

People Say

★4.5Overall rating based on 300+ reviews

This serum is highly praised for its "Peptide-Rich Plasma" technology, which users credit for rapidly improving skin texture, firmness, and radiance. While many describe it as a "holy grail" for anti-aging and hydration, a subset of users feel the high price tag is not justified by the results, which can be subtle for some.

Highlights

  • High price Mostly Mentioned
    • “hefty price tag”
    • “hard to justify”
    • “investment skincare”
    • “wallet-draining”
  • Fast absorption Often Mentioned
    • “Lightweight, non-sticky, sinks in immediately, satin finish, layers well”
  • Visible anti-aging Often Mentioned
    • “Smoother fine lines, plumper skin, increased firmness, brighter complexion, "instant glow."”
  • High-tech ingredients Sometimes Noted
    • “Peptide-Rich Plasma, bio-identical actives, stem cell technology, clean formula, fragrance-free”
  • Hydration Sometimes Noted
    • “Deeply hydrating, restores moisture barrier, skin feels bouncy, eliminates dryness”
  • Lack of results Sometimes Noted
    • “No visible difference”
    • “didn't work for me”
    • “overhyped”
    • “saw no change”
    • “cheaper alternatives work better”
  • Packaging Rarely Noted
    • “Sleek black bottle, airless pump, luxurious design, dispenses perfect amount”
  • Availability issues Rarely Noted
    • “Frequently sold out”
    • “hard to find”
    • “waitlists”
    • “stock issues”
  • No acne benefit Rarely Noted
    • “Did not help breakouts”
    • “didn't reduce acne”
    • “neutral on blemishes”
  • Texture complaints Rarely Noted
    • “Slightly tacky for some”
    • “hard to spread (rare)”
    • “leaves a film”
    • “requires quick application”

Sources: lovi.care, nordstrom.com, violetgrey.com, editorialist.com, whowhatwear.com, reddit.com, and more

Questions and answers

How well does Eighth Day Regenerative Serum work for sensitive skin?

This serum works moderately well for sensitive skin because it helps repair the skin barrier and keeps it hydrated, though its multiple peptides and glycolic acid may not adequately address redness and irritation. A product of this type needs strong anti-inflammatory ingredients and soothing components to properly calm sensitive skin.

Journal of Pharmacy & Pharmaceutical Sciences, 2015Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

Which ingredients make this serum a good fit for sensitive skin?

Sodium hyaluronate, sea whip extract, and allantoin help keep your skin hydrated and calm, though sensitive skin also needs specialized ingredients to target redness and irritation without the risk of irritation from glycolic acid.

Journal of Pharmacy & Pharmaceutical Sciences, 2015Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

What does Peptide-Rich Plasma do for sensitive skin?

Platelet-rich plasma is unlikely to benefit sensitive skin directly and may cause irritation, as studies show it does not improve texture or aging signs in normal use. Sensitive skin needs gentle ingredients that calm irritation and strengthen the moisture barrier, such as ceramides and centella asiatica.

Plastic and Reconstructive Surgery. Global Open, 2024Journal of Cosmetic Dermatology, 2025

What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.

Journal of Drugs in Dermatology, 2025Journal of Cosmetic Dermatology, 2018

Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine for sensitive skin. To truly calm redness and irritation, this skin type needs a product of this type with stronger anti-inflammatory ingredients and specialized soothing care.

Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol, though sensitive skin needs a product that provides stronger soothing and anti-inflammatory ingredients to calm redness and irritation.

How often should I use this serum?

This serum works well in the evening routine, as treatments fit best at night for simplicity and safety around sun exposure. Sensitive skin needs products with specialized soothing ingredients and stronger anti-inflammatory agents to better calm redness and irritation.

Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is generally safe for sensitive skin and is unlikely to clog pores or cause breakouts, though glycolic acid poses a slight risk of irritation. Sensitive skin dealing with redness needs formulas with stronger calming ingredients and specialized anti-inflammatory agents to properly soothe the skin.

Journal of Pharmacy & Pharmaceutical Sciences, 2015Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.

    Journal of Pharmacy & Pharmaceutical Sciences, 2015

  • Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

    Dermatologic Therapy, 2022

  • Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.

    Drug Delivery, 2017

  • A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.

    Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

  • Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.

    Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016

  • Topical insulin combined with fractional CO2 laser showed no significant difference in efficacy compared to topical PRP combined with fractional CO2 laser for atrophic acne scars in 30 patients.

    Archives of Dermatological Research, 2025

  • Subcision and microneedling combined with topical platelet-rich plasma resulted in significantly greater improvement in scar grading compared to subcision and microneedling alone in patients with atrophic scars.

    Journal of Cutaneous and Aesthetic Surgery, 2024

  • Platelets remain viable for up to 90 days in a refrigerated cosmetic vehicle with demonstrated topical clinical PRP facial benefits, and 20ml and 60ml PRP volumes are equally efficacious.

    Journal of Drugs in Dermatology, 2020

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Topical overnight application of MGO Manuka Honey microemulsion eye cream significantly reduced symptomology, improved tear film stability and lipid layer thickness, and decreased lid margin staining, ocular Demodex, and bacterial load in patients with blepharitis compared to control eyes.

    The Ocular Surface, 2020

  • Optimel 16% manuka honey eye-drops significantly improved symptoms and objective signs in patients with meibomian gland dysfunction compared to baseline after 3 weeks.

    The British Journal of Ophthalmology, 2022

  • The application of Manuka honey and the GENADYNE A4 negative pressure wound therapy system in a 55-year-old woman with extensive phlegmonous and necrotic lesions following traumatic colonic rupture successfully enabled skin autografting and complete wound healing.

    Medical Science Monitor, 2010

Why other serums fit sensitive skin better

Ingredients

Water, Pentylene Glycol, Peptide-Rich Plasma, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Acetyl Glutamine, Sodium Hyaluronate, Lysine Hcl, Alanine, Histidine Hcl, Arginine, Serine, Proline, Glutamic Acid, Threonine, Valine, Leucine, Glycine, Isoleucine, Phenylalanine, Taurine, Glycerin, Hedychium Coronarium Root Extract, Tripeptide-1, Polygonum Aviculare Extract, Honey, Nonapeptide-1, Acetyl Heptapeptide-4, Phytosphingosine, Sea Whip Extract, Niacinamide, Hydrolyzed Hyaluronic Acid, Aminobutyric Acid, Adenosine, Thioctic Acid, Glycolic Acid, Bacillus Soybean Folic Acid Extract Ferment, Polysorbate 20, Allantoin, Caprylyl Glycol, Lecithin, Butylene Glycol, 1,2-Hexanediol, Dextran, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play