# Dr. Althea 345 Relief Cream for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Dr. Althea](https://lovi.care/skincare/nl/brands/dr-althea)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for combination skin.

## Why this fit

- Highly suitable for your combination skin, this cream effectively addresses oily shine with niacinamide to help regulate sebum and hyaluronic acid for hydration and barrier resilience. Panthenol further supports barrier repair, enhancing overall skin health.
- The formula is safe for your combination skin, containing no harsh or prohibited ingredients that could cause irritation.
- This product offers excellent moisturizing and treating benefits, making it a great choice for maintaining healthy, balanced skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/oily-acne-prone-skin): Superior

## Key ingredients

Niacinamide, Centella Asiatica, Hyaluronic Acid, Ceramide, Oenothera Biennis Oil

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Topical application of linseed, evening primrose, and olive oil emulsions accelerated wound closure in rats with excision wounds compared to untreated controls, though via different mechanisms. ([Drug Delivery and Translational Research, 2019](https://pubmed.ncbi.nlm.nih.gov/29667150/))

## What reviewers say

Based on a very large amount of data, this gel-cream is highly regarded by users with oily and acne-prone skin for its lightweight, fast-absorbing texture that effectively soothes redness and strengthens the skin barrier without causing pore congestion. Some users with dry skin find it insufficiently moisturizing, and a few report occasional breakouts or pilling when layered with other products.

- Liked: Hydrating for Oily Skin (often mentioned)
- Liked: Lightweight & Fast Absorbing (often mentioned)
- Liked: Soothing & Calming (often mentioned)
- Liked: Improves Skin Texture (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Not moisturizing enough (sometimes noted)
- Disliked: Pilling issues (rarely noted)
- Disliked: Scent/Irritation (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Dr. Althea 345 Relief Cream a great fit for combination skin?

This cream is a great fit for your combination skin because it uses niacinamide to help control oily shine and hyaluronic acid to keep skin hydrated without feeling heavy. It is very safe for this skin type, as it contains no harsh ingredients that might cause irritation, and it helps calm and balance your skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this cream a good fit for combination skin?

Niacinamide helps regulate oily shine, while hyaluronic acid provides hydration and panthenol supports barrier repair. Together, these key ingredients help keep combination skin balanced, soft, and healthy without causing irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Centella Asiatica do for combination skin?

Centella asiatica helps calm combination skin, keeps it balanced, and supports the moisture barrier without feeling heavy. It may also reduce redness and help keep breakouts under control.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Where does this cream go in a skincare routine for combination skin?

This moisturizing treatment is used as the third step in your morning routine after a cleanser and hydrating toner, and as the final step in your evening routine after your treatment. It helps keep your skin balanced by providing hydration while addressing oily shine.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol, applying it after your retinol treatment to help soothe the skin and maintain moisture. Its gentle ingredients are unlikely to cause irritation, making it a safe choice to buffer the drying effects of stronger treatments.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily to maintain balanced skin and support your moisture barrier. Regular application helps improve skin hydration and texture while keeping combination skin calm and smooth.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores, but some reviewers with combination skin report that it may cause breakouts. The formula avoids harsh ingredients to keep your skin safe, though individual reactions can still happen.

### Can I use this cream around the eyes or on my body?

You can use this cream on the thin skin around the eyes and on the body because its gentle moisturizing ingredients provide safe hydration and barrier support for delicate areas. Studies on similar hydrating and soothing formulations show they improve moisture and smooth fine lines without causing irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [MISSHA Premium Cica Aloe Soothing Gel](https://lovi.care/skincare/nl/p/missha/premium-cica-aloe-soothing-gel/for/combination-skin) — High fit — €10.00 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/nl/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — €13.02 at Amazon
- [Anua Heartleaf 78% Soothing Cream](https://lovi.care/skincare/nl/p/anua/heartleaf-78-soothing-cream/for/combination-skin) — High fit — €25.29 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/nl/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €16.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/nl/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/combination-skin) — Superior fit — €33.70 at Amazon

## Where to buy

- Amazon.nl: €61.59 (https://www.amazon.nl/dp/B0FMDRCHXV?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Notino: €13.50 (https://www.notino.nl/dr-althea/345-relief-cream-mist-hydraterende-en-voedende-tonic-met-kalmerend-effect/p-16384349/)
- Lookfantastic: €18.75 (https://www.lookfantastic.nl/p/dr.-althea-345-relief-cream-50ml/17729496/)
Prices checked 10 Oct – 5 Nov 2026.

## Ingredients

Water, Propanediol, Glycerin, Cyclohexasiloxane, 1,2-Hexanediol, Caprylic Capric Triglyceride, Niacinamide, Panthenol, Polyglycerin-3, Polyglyceryl-10 Stearate, Hydrogenated Poly C6-14 Olefin, Hydrogenated Polydecene, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Melia Azadirachta Flower Extract, Houttuynia Cordata Extract, Melia Azadirachta Leaf Extract, Oenothera Biennis Flower Extract, Curcuma Longa Root Extract, Ocimum Sanctum Leaf Extract, Calendula Officinalis Flower Extract, Agave Tequilana Leaf Extract, Sargassum Fulvellum Extract, Corallina Officinalis Extract, Lavandula Angustifolia Flower Extract, Centella Asiatica Leaf Extract, Opuntia Ficus-Indica Stem Extract, Gardenia Florida Fruit Extract, Perilla Ocymoides Leaf Extract, Hibiscus Sabdariffa Flower Extract, Hyaluronic Acid, Hydrogenated Lecithin, Empetrum Nigrum Fruit Juice, Dicaprylyl Carbonate, C14-22 Alcohols, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polymethylsilsesquioxane, Dipropylene Glycol, Butylene Glycol, C12-20 Alkyl Glucoside, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Polyquaternium-51, Tromethamine, Fructooligosaccharides, Adenosine, Beta-Glucan, Glycine Soja Soybean Sterols, Peg-40 Castor Oil, Hydrolyzed Hyaluronic Acid, Resveratrol, Tocopherol, Ceramide Np, Oligopeptide-1, Phenoxyethanol, Potassium Sorbate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/dr-althea/345-relief-cream/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/dr-althea/345-relief-cream/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/dr-althea/345-relief-cream/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/dr-althea/345-relief-cream/for/combination-skin
- France: https://lovi.care/skincare/fr/p/dr-althea/345-relief-cream/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/dr-althea/345-relief-cream/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/dr-althea/345-relief-cream/for/combination-skin (this page)
- Spain: https://lovi.care/skincare/es/p/dr-althea/345-relief-cream/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/dr-althea/345-relief-cream/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/dr-althea/345-relief-cream/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/dr-althea/345-relief-cream/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/dr-althea/345-relief-cream/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/dr-althea/345-relief-cream/for/combination-skin