# Differin Daily Deep Cleanser for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Differin](https://lovi.care/skincare/nl/brands/differin)
Category: [Cleansers](https://lovi.care/skincare/nl/best/cleansers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other cleansers fit it better.

## Why this fit

- Offers moderate cleansing for your combination skin due to sodium c14-16 olefin sulfonate effectively removing impurities, while benzoyl peroxide provides antimicrobial action to help manage oily shine.
- Glycerin is present to offer some hydration, but additional humectants would better support drier areas of your combination skin.
- The formula is safe for your combination skin, as it lacks prohibited or harsh ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/oily-acne-prone-skin): Average

## Key ingredients

Benzoyl Peroxide, Glycerin, Carbomer, Lauryl Methacrylate Glycol Dimethacrylate Crosspolymer, Sodium C14-16 Olefin Sulfonate

## What the research says

- Topical benzoyl peroxide may improve acne more effectively than placebo or no treatment, while showing little to no difference compared with adapalene or clindamycin, but with an increased risk of treatment discontinuation due to adverse effects compared to placebo. ([The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/))
- Preoperative treatment with benzoyl peroxide significantly decreases the bacterial skin load of Cutibacterium acnes in patients undergoing elective shoulder surgery from skin incision until wound closure compared to preparation with soap. ([Journal of Shoulder and Elbow Surgery, 2021](https://pubmed.ncbi.nlm.nih.gov/33545336/))
- Once-daily fixed-dose clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel achieved superior treatment success (52.5%) and greater reductions in inflammatory and noninflammatory lesions compared to vehicle (8.1%) and dyad component gels in participants with moderate-to-severe acne over 12 weeks. ([American Journal of Clinical Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34674160/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/))
- Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel achieved significantly greater treatment success and lesion reductions compared to vehicle in participants with moderate-to-severe acne. ([Journal of the American Academy of Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37656094/))
- Daily application of adapalene 0.3%/benzoyl peroxide 2.5% gel reduced and prevented atrophic acne scar formation, achieving a total scar count change of -15.5% versus +14.4% for vehicle over 24 weeks in 67 subjects with moderate or severe facial acne. ([American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical chloramphenicol-betamethasone combined with sodium hyaluronate/trehalose/carbomer gel compared to chloramphenicol-betamethasone alone reduced most subjective symptoms at 1 week but increased blurred vision at 4 weeks following strabismus surgery in 31 patients, with no significant differences in conjunctival inflammation between treatments. ([Journal of Ocular Pharmacology and Therapeutics, 2019](https://pubmed.ncbi.nlm.nih.gov/31298607/))
- Incorporating nanoemulsions into hydrogels with increasing Carbopol 934 proportions from 1% to 3% progressively decreased the percutaneous flux rates of terbinafine and citral, increased drug accumulation in the stratum corneum while decreasing it in the epidermis/dermis compared to nanoemulsions alone, and shifted delivery routes from skin appendages to intercellular paths. ([International Journal of Nanomedicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27877042/))
- Topical liquiritin carbomer gel treatment restored skin barrier function, increased barrier proteins and antioxidant enzymes, and decreased inflammatory cytokines and oxidative stress in a mouse model of glucocorticoid-induced skin inflammation. ([Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/39204346/))

## What reviewers say

Based on a very large amount of data, users widely praise this cleanser as a "holy grail" for managing acne-prone and sensitive skin, noting that its 5% benzoyl peroxide formula effectively clears hormonal and cystic breakouts without the extreme irritation often associated with stronger treatments. While most find it surprisingly gentle and non-stripping, a minority of users experience dryness or peeling, and many warn that the product will permanently bleach towels and clothing.

- Liked: Gentle on sensitive skin (mostly mentioned)
- Disliked: Bleaches fabrics (mostly mentioned)
- Liked: Effective acne treatment (often mentioned)
- Liked: Non-stripping/drying (often mentioned)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Drying for some (sometimes noted)
- Disliked: Runny consistency (sometimes noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use this cleanser AM and PM as part of your daily routine. Start 3×/week and build up to daily use if your skin tolerates it well.
- Apply this cleanser as the very first step in your morning routine and right after your pre-cleanser in the evening.
- Gently massage a small amount of cleanser onto your skin using circular motions. Rinse thoroughly with lukewarm water.
- For the best results , apply the cleanser directly onto slightly damp skin to help lift away excess oil.
- Avoid the immediate eye area and do a patch test before your first use to check for any sensitivity.
- Video: https://storage.pora.ai/6a08416bd9315041c09c72f61cf27cc1.mp4

## Questions and answers

### How well does Differin Daily Deep Cleanser work for combination skin?

This cleanser works moderately well for your combination skin, using benzoyl peroxide to manage oily shine and glycerin to offer some hydration, though a product of this type needs additional hydrating and barrier-repairing ingredients to better support drier areas.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/)

### Which ingredients make this cleanser a good fit for combination skin?

This cleanser works for combination skin because sodium c14-16 olefin sulfonate removes impurities, benzoyl peroxide helps manage oily shine, and glycerin provides hydration. However, combination skin needs cleansers with additional hydrating ingredients and barrier-repairing agents to better support drier areas.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/)

### What does Benzoyl Peroxide do for combination skin?

Benzoyl peroxide helps clear acne and reduce blemishes for combination skin by targeting breakout-causing bacteria. Because it can sometimes cause dryness or tightness in sensitive areas, it is important to follow with a good moisturizer to keep the skin balanced.
Sources: [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23839205/)

### What does Glycerin do for combination skin?

Glycerin helps keep combination skin soft and smooth by pulling moisture in and keeping it there. It improves hydration and supports your skin barrier, which is unlikely to cause irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this cleanser go in a skincare routine for combination skin?

This cleanser fits into both your morning and evening routine as the main cleansing step. To best care for combination skin, a cleanser of this type needs extra hydrating ingredients like glycerin and additional humectants to keep drier areas comfortable while managing oily shine.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cleanser with retinol, and in what order?

Using this cleanser with retinol may dry out your combination skin, so you should introduce them slowly or use them on alternate days to lower the risk of irritation. When using both, apply the cleanser first, rinse thoroughly, and follow with your retinol product after your skin is completely dry. Combination skin of this type needs additional hydrating ingredients like hyaluronic acid or extra glycerin to better support drier areas alongside benzoyl peroxide.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/), [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/)

### How often should I use this cleanser?

You can use this cleanser daily as part of your morning and evening routine to help manage oily shine while remaining safe for your combination skin. However, since this type of product can be drying, a cleanser for combination skin needs extra hydrating ingredients to better support drier areas.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/)

### Can this cleanser clog pores, cause breakouts or purging for combination skin?

This cleanser is unlikely to clog your pores, and while it helps manage breakouts with benzoyl peroxide, it may leave drier areas feeling a bit dry. A product for this skin type needs extra hydrating ingredients like hyaluronic acid to better support the drier zones while keeping the oily areas clear.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/)

### Can I use this cleanser around the eyes or on my body?

This cleanser works fine on body skin, but the thin skin around the eyes is much more delicate and prone to irritation from benzoyl peroxide and strong cleansing agents. For treating areas like the body, a cleanser of this type needs effective antibacterial ingredients and deep cleansing agents to clear impurities, alongside extra hydrators to keep skin soft.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/)

## Alternatives for combination skin

- [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/nl/p/cerave/foaming-facial-cleanser/for/combination-skin) — Superior fit — €21.00 at Amazon
- [Eminence Organic Skin Care Clear Skin Probiotic Cleanser](https://lovi.care/skincare/nl/p/eminence-organic-skin-care/clear-skin-probiotic-cleanser/for/combination-skin) — Superior fit — €79.88 at Amazon
- [Cetaphil Daily Facial Cleanser](https://lovi.care/skincare/nl/p/cetaphil/daily-facial-cleanser/for/combination-skin) — High fit — €13.45 at Amazon

## Pairs well with

- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/combination-skin) — Superior fit — €19.20 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/nl/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/combination-skin) — Superior fit — €33.70 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Benzoyl Peroxide, Carbomer, Glycerin, Lauryl Methacrylate Glycol Dimethacrylate Crosspolymer, Sodium C14-16 Olefin Sulfonate, Sodium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/differin/daily-deep-cleanser/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/differin/daily-deep-cleanser/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/differin/daily-deep-cleanser/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/differin/daily-deep-cleanser/for/combination-skin
- France: https://lovi.care/skincare/fr/p/differin/daily-deep-cleanser/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/differin/daily-deep-cleanser/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/differin/daily-deep-cleanser/for/combination-skin (this page)
- Spain: https://lovi.care/skincare/es/p/differin/daily-deep-cleanser/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/differin/daily-deep-cleanser/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/differin/daily-deep-cleanser/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/differin/daily-deep-cleanser/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/differin/daily-deep-cleanser/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/differin/daily-deep-cleanser/for/combination-skin