# COSRX The Niacinamide 15 Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [COSRX](https://lovi.care/skincare/nl/brands/cosrx)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers moderate treatment for your acne, blemishes, and breakouts as niacinamide and zinc PCA help regulate sebum production and reduce inflammation, which is beneficial for your combination skin.
- The presence of acetyl glucosamine and trehalose further supports skin hydration and barrier function, contributing to overall skin health.
- The formula is safe for your acne-prone skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Acetyl Glucosamine, Zinc Pca, Trehalose, Allantoin

## What the research says

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- Sodium trehalose sulfate decreased transepidermal water loss and increased stratum corneum water content in participants with low stratum corneum water content when applied for 4 weeks compared to placebo. ([Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38606717/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Liposomes containing N-acetyl glucosamine prepared using the fusion method significantly increased skin moisture content compared to empty liposomes in human volunteers over a 5-hour period. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23725302/))
- Zinc PCA inhibits UVA-induced matrix metalloproteinase-1 production through suppressed AP-1 activation and enhances type I collagen synthesis by increasing SVCT2 mRNA expression in cultured normal human dermal fibroblasts. ([International Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/21834944/))
- Topical chloramphenicol-betamethasone combined with sodium hyaluronate/trehalose/carbomer gel compared to chloramphenicol-betamethasone alone reduced most subjective symptoms at 1 week but increased blurred vision at 4 weeks following strabismus surgery in 31 patients, with no significant differences in conjunctival inflammation between treatments. ([Journal of Ocular Pharmacology and Therapeutics, 2019](https://pubmed.ncbi.nlm.nih.gov/31298607/))
- Topical treatment with Thealoz Duo significantly improved dry eye disease symptoms, tear break-up time, and restored tear lipid layer functionality by reducing inflammatory response proteins in moderate to severe dry eye patients over 56 days. ([Journal of Clinical Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/40807147/))
- An injectable product combining different molecular weights of hyaluronic acid and trehalose reduced CML formation by 45% at baseline and 30% under methylglyoxal-induced stress while preserving cell viability in human skin explants compared to untreated controls. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40244036/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## What reviewers say

This serum is widely praised by users with oily and acne-prone skin for its ability to significantly control sebum and refine pore texture, often delivering a smoother, "glass skin" finish. The high 15% concentration is effective for many, but frequently causes irritation, stinging, or barrier damage for those with sensitive or dry skin types. This summary is based on a very large amount of data and should be definitely taken into account.

- Liked: Controls excess oil (mostly mentioned)
- Liked: Lightweight absorption (often mentioned)
- Liked: Reduces pore visibility (often mentioned)
- Liked: Smoothes skin texture (often mentioned)
- Liked: Fades acne marks (sometimes noted)
- Disliked: Causes irritation (sometimes noted)
- Disliked: Too strong (sometimes noted)
- Disliked: Drying effect (rarely noted)
- Disliked: Induces breakouts (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes COSRX Niacinamide 15 Serum a great fit for acne-prone skin?

This serum is a great fit because niacinamide and zinc PCA help regulate oil and reduce inflammation to manage blemishes and breakouts. The formula also supports skin hydration and barrier health with acetyl glucosamine and trehalose, and is unlikely to cause irritation on acne-prone skin.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/)

### Which ingredients make this serum a good fit for acne-prone skin?

Niacinamide and zinc PCA make this serum a great fit for your acne-prone skin because they help calm inflammation and control oil. Acetyl glucosamine and trehalose further support your skin barrier and moisture levels.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### What does Acetyl Glucosamine do for acne-prone skin?

Acetyl Glucosamine is not a standard treatment for acne, but it helps fade dark marks and uneven spots left behind after breakouts clear. When you have acne-prone skin, a product of this type needs soothing ingredients and lightweight hydrators that keep pores clear without feeling greasy.
Sources: [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/), [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19845667/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment serum goes in the evening routine after cleansing and toning, and before moisturizing. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to help calm the skin and keep it hydrated while the retinol works. This formula is safe for acne-prone skin and is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. It helps manage breakouts and soothe your skin safely when used consistently.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for your acne-prone skin, as it contains zinc PCA and niacinamide to help control oil and soothe redness. Some reviewers mention irritation or feeling like the product is too strong, so you may want to start slowly.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.80 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/nl/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/acne-prone-skin) — Superior fit — €99.41 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/nl/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €19.20 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Niacinamide, Butylene Glycol, Acetyl Glucosamine, 1,2-Hexanediol, Zinc Pca, Trehalose, Hydrolyzed Sclerotium Gum, Pullulan, Allantoin, Ethylhexylglycerin, Sodium Phytate, Tocopherol, Xanthan Gum, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin (this page)
- Spain: https://lovi.care/skincare/es/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/cosrx/the-niacinamide-15-serum/for/acne-prone-skin