Clean & Clear Persa-Gel 10 for combination skin

How to apply

Questions and answers

What the research says

• Preoperative treatment with benzoyl peroxide significantly decreases the bacterial skin load of Cutibacterium acnes in patients undergoing elective shoulder surgery from skin incision until wound closure compared to preparation with soap.

  Journal of Shoulder and Elbow Surgery, 2021

• Topical benzoyl peroxide may improve acne more effectively than placebo or no treatment, while showing little to no difference compared with adapalene or clindamycin, but with an increased risk of treatment discontinuation due to adverse effects compared to placebo.

  The Cochrane Database of Systematic Reviews, 2020

• Once-daily fixed-dose clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel achieved superior treatment success (52.5%) and greater reductions in inflammatory and noninflammatory lesions compared to vehicle (8.1%) and dyad component gels in participants with moderate-to-severe acne over 12 weeks.

  American Journal of Clinical Dermatology, 2022

• Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate can be used safely in cosmetic formulations at concentrations up to 5%, and Benzyl Alcohol is safe up to 10% in hair dyes, despite causing nonimmunologic contact reactions.

  International Journal of Toxicology, 2001

• Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability.

  Journal of Cosmetic Dermatology, 2024

• Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel achieved significantly greater treatment success and lesion reductions compared to vehicle in participants with moderate-to-severe acne.

  Journal of the American Academy of Dermatology, 2023

• Daily application of adapalene 0.3%/benzoyl peroxide 2.5% gel reduced and prevented atrophic acne scar formation, achieving a total scar count change of -15.5% versus +14.4% for vehicle over 24 weeks in 67 subjects with moderate or severe facial acne.

  American Journal of Clinical Dermatology, 2018

• Topical chloramphenicol-betamethasone combined with sodium hyaluronate/trehalose/carbomer gel compared to chloramphenicol-betamethasone alone reduced most subjective symptoms at 1 week but increased blurred vision at 4 weeks following strabismus surgery in 31 patients, with no significant differences in conjunctival inflammation between treatments.

  Journal of Ocular Pharmacology and Therapeutics, 2019

• Incorporating nanoemulsions into hydrogels with increasing Carbopol 934 proportions from 1% to 3% progressively decreased the percutaneous flux rates of terbinafine and citral, increased drug accumulation in the stratum corneum while decreasing it in the epidermis/dermis compared to nanoemulsions alone, and shifted delivery routes from skin appendages to intercellular paths.

  International Journal of Nanomedicine, 2016

• Topical liquiritin carbomer gel treatment restored skin barrier function, increased barrier proteins and antioxidant enzymes, and decreased inflammatory cytokines and oxidative stress in a mouse model of glucocorticoid-induced skin inflammation.

  Pharmaceutics, 2024

• Biodegradable wound dressings functionalized with silver nanoparticles showed >99% pathogen growth inhibition, bactericidal effects, free radical scavenging, reduced inflammatory response in macrophages, and accelerated wound healing in animals.

  International Journal of Biological Macromolecules, 2022

• Hydroxypropyl methylcellulose hydrogel formulations of berberine chloride-loaded escinosomes increased skin residence time and transdermal permeability while maintaining high safety and biocompatibility without skin irritation.

  International Journal of Biological Macromolecules, 2020

Ingredients

Benzoyl Peroxide, Water, Carbomer Homopolymer Type B, Hydroxypropyl Methylcellulose, Sodium Hydroxide, Laureth-4, Disodium Edta, Benzyl Alcohol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.