# Bonajour Extreme Spot Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: Bonajour
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Highly suitable for your normal skin, this product effectively addresses wrinkles and fine lines with Nicotinoyl Dipeptide-23 and Salix Nigra Bark Extract, which promote anti-aging and mild exfoliation. Centella Asiatica Extract and Glycerin further enhance its compatibility by providing anti-inflammatory and humectant benefits.
- The formula also offers excellent treatment for reducing redness and calming irritation, thanks to moderate concentrations of Centella Asiatica Extract and Allantoin.
- Its safety profile is excellent, with no risks of irritation for your normal skin due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Niacinamide, Glycosaminoglycans, Allantoin, Akebia Quinata Extract

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical treatment with sphingolipids and glycosaminoglycans attenuated clinical worsening and reduced CADESI and PVAS scores compared to the untreated control group in house dust mite-allergic beagle dogs. ([BMC Veterinary Research, 2020](https://pubmed.ncbi.nlm.nih.gov/32197613/))
- Glycosaminoglycans restored type I collagen synthesis, reduced matrix metalloproteinase-1 levels, upregulated tissue inhibitor of metalloproteinase-1, and attenuated apoptosis in tumor necrosis factor-alpha-stimulated human dermal fibroblasts by inhibiting extracellular signal-regulated kinase/activator protein-1 signaling. ([International Journal of Molecular Medicine, 2018](https://pubmed.ncbi.nlm.nih.gov/29436595/))
- Fraction 3 of glycosaminoglycans from Liparis tessellatus eggs showed 20.1% tyrosinase inhibition at 50mg/mL and effective skin regeneration activities at 200mg/mL against skin fibroblast CCD-986sk cell lines. ([International Journal of Biological Macromolecules, 2017](https://pubmed.ncbi.nlm.nih.gov/28917941/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Akebia quinata fruit extract reduced CML expression, stimulated fibrillin-1 expression, and decreased deep crow's feet wrinkle depth in humans compared to treatment without the extract. ([Nutrients, 2015](https://pubmed.ncbi.nlm.nih.gov/26569300/))

## What reviewers say

Based on limited data, users with acne-prone and sensitive skin find this serum effective for calming breakouts and fading post-acne marks. It is frequently praised for soothing redness and providing hydration. A notable number of users report a temporary stinging sensation upon application and a sticky finish that takes time to absorb.

- Liked: Calms acne (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Disliked: Sticky texture (often mentioned)
- Liked: Deeply hydrating (sometimes noted)
- Disliked: Stinging sensation (sometimes noted)
- Disliked: Poor packaging (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Bonajour Extreme Spot Serum a great fit for mature skin?

Bonajour Extreme Spot Serum is a great fit for mature skin because it targets wrinkles and fine lines using Nicotinoyl Dipeptide-23 and willow bark extract for gentle exfoliation. It also features Centella asiatica extract and glycerin to calm irritation and keep skin hydrated.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Nicotinoyl Dipeptide-23 and Salix Nigra Bark Extract make this serum a great fit for mature skin by helping smooth out wrinkles and fine lines with mild exfoliation. Centella Asiatica Extract and Glycerin further help by calming irritation and keeping dry skin soft and plump.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Centella Asiatica Extract do for mature skin?

Centella Asiatica Extract helps mature skin by improving moisture, reducing moisture loss, and supporting collagen production to keep skin firm and smooth. It also provides antioxidant and calming benefits that help protect against everyday stress and visible signs of aging.
Sources: [Scientific Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34188145/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516082/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in the evening routine, after cleansing and before moisturizing, to keep things simple and safe around sun exposure. Using targeted serums helps smooth fine lines and calm irritation on mature skin.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to calm and hydrate your skin before putting on your retinol. This product has a very safe profile with soothing ingredients like Centella Asiatica Extract and Allantoin, which help keep irritation low.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### How often should I use it?

Use this treatment in your evening routine for simplicity and safety around sun exposure. Since it is a great fit for your mature skin, you can use it every evening to help smooth fine lines and calm irritation safely.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin due to its safe, soothing formula that avoids harsh ingredients. Centella Asiatica Extract and glycerin help keep skin calm and hydrated without heavy oils.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Clarins Double Serum](https://lovi.care/skincare/nl/p/clarins/double-serum/for/mature-skin) — High fit — €87.50 at Amazon
- [SKIN1004 Madagascar Centella Asiatica Ampoule](https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin) — Average fit — €15.49 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Centella Asiatica Extract, Glycerin, Water, Niacinamide, Akebia Quinata Extract, Nicotinoyl Dipeptide-23, Glycosaminoglycans, Salix Nigra Bark Extract Willow Bark Extract, Aminobutyric Acid, Allantoin, 1,2-Hexanediol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Butylene Glycol, Pentylene Glycol, Caprylyl Glycol, Xanthan Gum, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bonajour/extreme-spot-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/bonajour/extreme-spot-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/bonajour/extreme-spot-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/bonajour/extreme-spot-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/bonajour/extreme-spot-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/bonajour/extreme-spot-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/bonajour/extreme-spot-serum/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/bonajour/extreme-spot-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/bonajour/extreme-spot-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/bonajour/extreme-spot-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/bonajour/extreme-spot-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/bonajour/extreme-spot-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/bonajour/extreme-spot-serum/for/mature-skin