# Biossance Squalane + Ectoin Overnight Rescue for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Biossance](https://lovi.care/skincare/nl/brands/biossance)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few moisturizers fit it even better.

## Why this fit

- Offers excellent moisturizing and barrier repair for your dry and sensitive skin, as squalane and ectoin provide deep hydration and enhance skin resilience. Shorea Stenoptera Seed Butter further supports emollient action and barrier function.
- The formula is safe for your dry and sensitive skin, with ectoin and squalane acting as soothing agents and protecting against irritation.
- This product is highly suitable for your dry or flaky skin and sensitivity, offering relevant skincare benefits through its hydrating and protective ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Ectoin, Glycerin, Shorea Stenoptera Seed Butter, Acetyl Hexapeptide-8

## What the research says

- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Combining ectoine and mannitol with UV filters significantly improved protection of squalene oxidation, catalase activity, and trans-UCA compared to UV filters alone in 10 subjects on irradiated areas. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37539499/))
- Topical 7% ectoine during serial 1064-nm Nd:YAG laser therapy produced a greater reduction in skin erythema, improved stratum corneum hydration, reduced transepidermal water loss, and decreased low-echogenic pixels in thirty participants compared to a vehicle control. ([Biomedicines, 2026](https://pubmed.ncbi.nlm.nih.gov/42792808/))
- Regular application of a novel anti-ageing cream containing hyaluronic acid, ectoin, and botanical actives significantly reduced wrinkle depth and length in the periorbital area while demonstrating very good skin tolerance. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## What reviewers say

Most users report waking up to soft, plump, and soothed skin without irritation. Those with oily or acne-prone skin occasionally find the formula too rich. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Absorbs well (often mentioned)
- Liked: Plumps and softens (often mentioned)
- Liked: Soothes sensitive skin (often mentioned)
- Disliked: High price point (sometimes noted)
- Disliked: Heavy or greasy (rarely noted)
- Disliked: Jar packaging (rarely noted)
- Disliked: May cause breakouts (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Biossance Squalane + Ectoin Overnight Rescue a great fit for dry sensitive skin?

Biossance Squalane + Ectoin Overnight Rescue is a great fit because squalane and ectoin deeply hydrate and strengthen your skin barrier while protecting against irritation. Shorea Stenoptera seed butter and glycerin further support this by locking in moisture and keeping your skin soft and smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for dry sensitive skin?

Squalane, ectoin, and glycerin make this cream a great fit because they provide deep hydration and help repair the skin barrier. Ingredients like Shorea Stenoptera Seed Butter add rich moisture, while ectoin and squalane soothe the skin and protect against irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Squalane do for dry sensitive skin?

Squalane helps keep dry sensitive skin soft and smooth by locking in moisture and calming irritation without causing flare-ups. It is unlikely to cause redness or discomfort, making it a gentle choice that supports the skin barrier. This type of skin needs ingredients that deeply hydrate and soothe, such as plant oils and antioxidants.
Sources: [International Journal of Molecular Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/29280987/), [Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/)

### What does Ectoin do for dry sensitive skin?

Ectoin helps dry sensitive skin by acting as a protective shield that keeps moisture locked in and calms irritation. It may also protect your skin from daily damage and redness, leaving your face feeling smooth and comfortable.
Sources: [Arhiv Za Higijenu Rada I Toksikologiju, 2016](https://pubmed.ncbi.nlm.nih.gov/28033102/), [Journal of Materials Chemistry. B, 2024](https://pubmed.ncbi.nlm.nih.gov/39086221/)

### Where does this cream go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after your toner and before your moisturizer. It is a great fit because ingredients like squalane, ectoin, and glycerin provide deep hydration and help repair the skin barrier for dry and sensitive skin.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment after your retinol to help keep your skin calm and moisturized. Using a barrier-supporting moisturizer helps reduce dryness and irritation while your skin adjusts to retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

This moisturizing treatment is designed for your evening routine, where it helps repair your skin barrier and keep dry sensitive skin calm and deeply hydrated. Applying it once a day in the evening is typically enough to maintain smooth and comfortable skin.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for dry sensitive skin?

This cream is unlikely to clog pores or cause breakouts, as review complaints about breakouts are low and its ingredients are well tolerated by dry, sensitive skin. Squalane and ectoin help keep the skin calm and deeply hydrated without feeling heavy.

### Can I use this cream around the eyes or on my body?

This cream is a great fit for your dry sensitive skin because squalane, ectoin, and glycerin provide deep hydration and help repair your skin barrier. Clinical studies show that creams with ingredients like ectoin reduce wrinkles around the eyes with very good skin tolerance.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/nl/p/the-ordinary/natural-moisturizing-factors-ha/for/dry-sensitive-skin) — Superior fit — €13.02 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/nl/p/l-occitane/immortelle-divine-cream/for/dry-sensitive-skin) — Superior fit — €69.99 at Amazon
- [COSRX Advanced Snail 92 All in One Cream](https://lovi.care/skincare/nl/p/cosrx/advanced-snail-92-all-in-one-cream/for/dry-sensitive-skin) — Superior fit — €9.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/nl/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €15.00 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/nl/p/skin1004/centella-asiatica-toning-toner/for/dry-sensitive-skin) — Superior fit — €17.96 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/nl/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — €16.75 at Amazon

## Where to buy

- Lookfantastic: €62.10 (https://www.lookfantastic.nl/p/biossance-squalane-and-ectoin-overnight-rescue-50ml/15065083/)
Prices checked 28 Oct 2026.

## Ingredients

Water, Glycerin, Squalane, Shorea Stenoptera Seed Butter, Caprylic Capric Triglyceride, C12-16 Alcohols, Sodium Acrylates Copolymer, Ectoin, Jojoba Esters, Acetyl Hexapeptide-8, Magnesium Chloride, Palmitic Acid, Hydrogenated Lecithin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Lecithin, Sorbitan Isostearate, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Sodium Gluconate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin (this page)
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin