# BIOEFFECT EGF Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [BIOEFFECT](https://lovi.care/skincare/nl/brands/bioeffect)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin regeneration for your acne, blemishes, and breakouts due to rh-oligopeptide-1 barley sh-oligopeptide-1 supporting skin regeneration and reducing inflammation.
- Highly suitable for your combination skin as glycerin and sodium hyaluronate provide humectant action, supporting hydration without exacerbating oiliness.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/oily-acne-prone-skin): High

## Key ingredients

Rh-Oligopeptide-1, Glycerin, Sodium Hyaluronate, Hordeum Vulgare Seed Extract, Tromethamine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Lidocaine at 20% and lidocaine 10% with trometamol provided effective pain control comparable to lidocaine/prilocaine in healthy adults after a 60-minute exposure, while propylene glycol did not accelerate the onset of analgesia. ([Journal of Pain Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28546768/))
- A Tris/Arg-formulated cleanser significantly decreased noninflammatory and inflammatory acne and pore size with keratotic plugs compared to an AEC/AC cleanser in male Thai subjects with mild to moderate acne over 4 weeks. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31347768/))
- Ketorolac tromethamine poloxamer hydrogel provided sufficient bioavailability to reach the site of action with anti-inflammatory efficacy and no visual skin irritation in volunteers. ([Pharmaceutical Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28540502/))

## What reviewers say

Users with dry, mature, or dehydrated skin highly praise this serum for its deep hydration, plumping effects, and ability to reduce fine lines, resulting in a radiant complexion. Some users with oily or combination skin find the texture sticky or heavy.

- Liked: Hydrating and plumping (mostly mentioned)
- Liked: Radiant glow (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Improves texture (sometimes noted)
- Disliked: Sticky texture (sometimes noted)
- Disliked: Too heavy (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes BIOEFFECT EGF Serum a great fit for acne-prone skin?

BIOEFFECT EGF Serum is a great fit because it helps regenerate skin and calm blemishes without causing irritation. Glycerin and sodium hyaluronate add hydration to the skin without making it oily.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for acne-prone skin because rh-oligopeptide-1 supports skin regeneration and helps reduce inflammation around breakouts. Additionally, glycerin and sodium hyaluronate provide hydration without adding extra oiliness, and the formula contains no harsh ingredients that might cause irritation.

### What does EGF do for acne-prone skin?

EGF helps calm acne-prone skin by reducing both inflamed and non-inflamed breakouts. It supports skin healing and barrier repair, making it a useful option for improving overall skin texture.
Sources: [International Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24962549/)

### What does Glycerin do for acne-prone skin?

Glycerin helps keep acne-prone skin hydrated and calm without clogging pores or feeling heavy. It supports the skin barrier so it stays soft and smooth while handling everyday treatments.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [International Journal of Toxicology, 2019](https://pubmed.ncbi.nlm.nih.gov/31840548/)

### Where does it go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting it at night keeps it simple and safe around sun exposure while helping your acne, blemishes, and breakouts.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to support hydration and skin recovery, followed by your retinol. This approach helps maintain moisture and is unlikely to cause irritation on acne-prone skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use it?

Use this serum in the evening as part of your routine. It helps support skin regeneration and hydration without causing irritation or adding oiliness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts or clog pores on acne-prone skin because it relies on hydrating ingredients like glycerin and sodium hyaluronate that provide moisture without adding extra oiliness. It also features plant-based growth factors that help support skin renewal and calm inflammation safely.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.80 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €160.00 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/nl/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €19.20 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Glycerin, Water, Sodium Hyaluronate, Tromethamine, Sodium Chloride, Hordeum Vulgare Seed Extract, Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bioeffect/egf-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/bioeffect/egf-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/bioeffect/egf-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/bioeffect/egf-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/bioeffect/egf-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/bioeffect/egf-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/bioeffect/egf-serum/for/acne-prone-skin (this page)
- Spain: https://lovi.care/skincare/es/p/bioeffect/egf-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/bioeffect/egf-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/bioeffect/egf-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/bioeffect/egf-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/bioeffect/egf-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/bioeffect/egf-serum/for/acne-prone-skin