# Bioderma Sensibio Defensive for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Bioderma](https://lovi.care/skincare/nl/brands/bioderma)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing for your combination skin, as glycerin and xylitol hydrate and enhance barrier resilience, but it lacks targeted ingredients to effectively address your acne, blemishes, and breakouts.
- The formula provides general skincare benefits with supportive ingredients like tocopherol, though it could benefit from enhanced oil control for your oily areas.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing agents like glycyrrhetinic acid and laminaria ochroleuca extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/oily-acne-prone-skin): Average

## Key ingredients

Glycerin, Glycyrrhetinic Acid, Laminaria Ochroleuca Extract, Tocopherol, Fructooligosaccharides

## What the research says

- A formulation containing glycerol (5%) and xylitol (5%) applied twice daily for 14 days increased skin hydration, filaggrin protein quantity, interdigitation index, and biomechanical properties, and decreased transepidermal water loss compared to untreated and vehicle-treated skin in twelve volunteers with dry skin. ([Acta Dermato-venereologica, 2017](https://pubmed.ncbi.nlm.nih.gov/27349297/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- A dermo-cosmetic formula containing 2% enoxolone significantly reduced erythema at 24 hours and pain at 30 minutes following non-ablative fractional laser treatment in 10 healthy subjects compared to a moisturizer control. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38622995/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of a cream containing 2.5% glycyrrhetinic acid significantly reduced thigh fat thickness and circumference compared to placebo in healthy women. ([Steroids, 2005](https://pubmed.ncbi.nlm.nih.gov/15894038/))
- Topical application of B-Resorcinol and Glycyrrhetinic acid effectively lightens hand solar lentigines after 4 weeks of treatment both with and without prior fractional laser photothermolysis, showing no statistical difference between the two approaches. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27325103/))
- Glycyrrhetinic acid inhibited skin 11 beta-hydroxysteroid dehydrogenase and potentiated the vasoconstrictor action of hydrocortisone. ([Lancet, 1990](https://pubmed.ncbi.nlm.nih.gov/1970371/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))

## Why other moisturizers fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Bioderma Sensibio Defensive work for acne-prone skin?

Bioderma Sensibio Defensive provides moderate hydration and calms acne-prone skin, but it lacks targeted ingredients to address breakouts. A product of this type needs specific ingredients for acne and blemishes, oil control, and soothing agents to truly fit this skin.
Sources: [Acta Dermato-venereologica, 2017](https://pubmed.ncbi.nlm.nih.gov/27349297/)

### Which ingredients make this cream a good fit for acne-prone skin?

Glycerin, xylitol, glycyrrhetinic acid, and laminaria ochroleuca extract help hydrate your skin and calm irritation without clogging pores. However, because this cream lacks targeted blemish-fighting ingredients and oil control, acne-prone skin needs a product with specialized blemish-clearing ingredients and oil-balancing agents.
Sources: [Acta Dermato-venereologica, 2017](https://pubmed.ncbi.nlm.nih.gov/27349297/)

### What does Glycerin do for acne-prone skin?

Glycerin helps keep acne-prone skin hydrated and calm without clogging pores or feeling heavy. It supports the skin barrier so it stays soft and smooth while handling everyday treatments.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [International Journal of Toxicology, 2019](https://pubmed.ncbi.nlm.nih.gov/31840548/)

### What does Glycyrrhetinic Acid do for acne-prone skin?

Glycyrrhetinic acid helps calm redness and irritation while balancing the skin to keep breakouts at bay. It is often paired with soothing agents and gentle hydrators to support acne-prone skin without clogging pores.
Sources: [International Journal of Pharmaceutics, 2025](https://pubmed.ncbi.nlm.nih.gov/40020947/)

### Where does it go in a skincare routine for acne-prone skin?

This moisturizing treatment goes near the end of your morning and evening routines, right before sunscreen in the morning. It helps keep your skin soft, but acne-prone skin also needs targeted blemish-fighting ingredients and oil control to really clear things up.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol, and applying it before your retinol helps keep your skin calm and comfortable while it adjusts. A product of this type works well for acne-prone skin when it also includes targeted blemish-fighting ingredients and oil control.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

You can use this moisturizing treatment daily to keep your skin soft and hydrated. Twice-daily application helps maintain moisture and calm the skin while supporting overall barrier health.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to clog pores or cause purging, as it is free from harsh ingredients and includes soothing agents that are safe for your skin. However, because it lacks targeted ingredients for breakouts, acne-prone skin needs a product with effective oil control and blemish-fighting ingredients.

### Can I use it around the eyes or on my body?

You can use it around the eyes or on your body, as the formula is safe and well-tolerated by the skin in those areas. This product provides general moisturizing benefits, though a cream for these specific regions often needs targeted ingredients for skin thickness and localized concerns.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for acne-prone skin

- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/nl/p/belif/the-true-cream-aqua-bomb/for/acne-prone-skin) — High fit — €35.96 at Amazon
- [ANUA Heartleaf 70% Soothing Cream](https://lovi.care/skincare/nl/p/anua/heartleaf-70-soothing-cream/for/acne-prone-skin) — High fit — €25.29 at Amazon
- [Purito Centella Unscented Recovery Cream](https://lovi.care/skincare/nl/p/purito/centella-unscented-recovery-cream/for/acne-prone-skin) — High fit — €12.55 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/nl/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €19.90 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/nl/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — €16.75 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Cetearyl Isononanoate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Mannitol, Xylitol, Rhamnose, Fructooligosaccharides, Laminaria Ochroleuca Extract, Tocopherol, Glycyrrhetinic Acid, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Sodium Hydroxide, Caprylic Capric Triglyceride, 1,2-Hexanediol, Caprylyl Glycol, Pentylene Glycol, Xanthan Gum, Disodium Edta, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bioderma/sensibio-defensive/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/bioderma/sensibio-defensive/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/bioderma/sensibio-defensive/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/bioderma/sensibio-defensive/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/bioderma/sensibio-defensive/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/bioderma/sensibio-defensive/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/bioderma/sensibio-defensive/for/acne-prone-skin (this page)
- Spain: https://lovi.care/skincare/es/p/bioderma/sensibio-defensive/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/bioderma/sensibio-defensive/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/bioderma/sensibio-defensive/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/bioderma/sensibio-defensive/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/bioderma/sensibio-defensive/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/bioderma/sensibio-defensive/for/acne-prone-skin