# AXIS-Y Spot The Difference Blemish Treatment for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [AXIS-Y](https://lovi.care/skincare/nl/brands/axis-y)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your oily skin is provided by salicylic acid and niacinamide, which work to regulate sebum and offer mild exfoliation, addressing your concerns about oily shine.
- The inclusion of Centella Asiatica Extract and Beta-Glucan further enhances the formula by soothing your skin and minimizing potential irritation.
- This product is safe for your skin, as it contains no harsh ingredients and is formulated to avoid irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Salicylic Acid Bha, Glycolic Acid Aha, 4-Terpineol, Ceramide Np

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- A foam formulation of 2% 4-terpineol killed common ocular microorganisms within 60 seconds and at 14 and 28 days without causing skin or ocular irritation in human subjects. ([BMJ Open Ophthalmology, 2018](https://pubmed.ncbi.nlm.nih.gov/30123842/))
- Topical tea tree oil and terpinen-4-ol produce good clinical outcomes in the management of Demodex blepharitis. ([Cornea, 2022](https://pubmed.ncbi.nlm.nih.gov/34743107/))
- Topical treatment with Australian tea tree oil and terpinen-4-ol effectively moderates human demodicosis by lowering mite counts, relieving symptoms, and modulating the inflammatory immune response. ([Parasitology, 2018](https://pubmed.ncbi.nlm.nih.gov/29667560/))

## What reviewers say

Users with acne-prone, oily, and sensitive skin praise this lightweight gel for effectively reducing redness and calming active breakouts without drying out the skin. While many experience fast results and appreciate the hydrating ceramide capsules, some find the bottle size too small and note that it may take time to see significant changes on stubborn blemishes.

- Liked: Gentle & non-drying (mostly mentioned)
- Liked: Effective acne relief (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Small product size (often mentioned)
- Liked: Good for sensitive skin (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Absorption issues (rarely noted)
- Disliked: Scent/applicator (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes AXIS-Y Spot The Difference Blemish Treatment a great fit for oily skin?

This treatment is a great fit because salicylic acid and niacinamide help control oily shine and gently smooth the skin. Centella asiatica extract and beta-glucan are also included to help calm the skin and keep irritation unlikely.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Which ingredients make this treatment a good fit for oily skin?

Salicylic acid and niacinamide make this treatment a great fit for your oily skin by helping control oily shine and providing mild exfoliation. Ingredients like Centella Asiatica extract and beta-glucan further calm your skin and may lower the chance of irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Salicylic Acid do for oily skin?

Salicylic acid helps oily skin by clearing excess oil and reducing breakouts while keeping skin comfortable and hydrated. Using it twice a day can significantly lower oil levels and improve overall skin balance.
Sources: [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682377/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35073439/)

### Where does this treatment go in a skincare routine for oily skin?

This treatment goes in your evening routine, applied after cleansing and toning and before moisturizing. Starting it once a week helps your oily skin adjust, and you may use it more often if you tolerate it well.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol by applying it during your evening routine, but using them on alternate nights may help lower the likelihood of irritation. This formula contains gentle soothing ingredients like Centella Asiatica Extract to help keep your skin calm while addressing breakouts.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### How often should I use this treatment?

Apply this treatment in your evening routine once a week to start. If your oily skin handles it well and shows good results, you can carefully use it more often.

### Can this treatment clog pores, cause breakouts or purging for oily skin?

This treatment is unlikely to clog pores or cause breakouts on oily skin, thanks to ingredients like salicylic acid and niacinamide that help clear away dead skin cells and keep oil in check. Centella Asiatica Extract and beta-glucan are also included to help keep your skin calm and minimize irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/nl/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/oily-skin) — Superior fit — €99.41 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — €35.80 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/nl/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — €21.00 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/oily-skin) — Superior fit — €19.20 at Amazon

## Where to buy

- Amazon.nl: €15.00 (https://www.amazon.nl/dp/B09HX96NKV?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €15.00 (https://www.lookfantastic.nl/p/axis-y-spot-the-difference-blemish-treatment-15ml/17735051/)
- Notino: €17.50 (https://www.notino.nl/axis-y/611-advanced-formula-spot-the-difference-blemish-treatment-lokale-verzorging-tegen-acne-voor-gevoelige-huid/p-16242175/)
Prices checked 12 Oct – 5 Nov 2026.

## Ingredients

Water, Glycerin, Propanediol, 1,2-Hexanediol, Glycereth-26, Niacinamide, Caprylic Capric Triglyceride, Aloe Barbadensis Leaf Extract, Althaea Rosea Flower Extract, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Centella Asiatica Extract, Ficus Carica Fruit Extract, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Camellia Sinensis Leaf Extract, Monarda Didyma Leaf Extract, Hydrangea Macrophylla Leaf Extract, Mentha Aquatica Extract, Sasa Quelpaertensis Extract, Melaleuca Alternifolia Tree Leaf Extract, Melia Azadirachta Leaf Extract, Eclipta Prostrata Extract, Camphor Leaf Extract, Cryptomeria Japonica Leaf Extract, Pinus Pinaster Bud Extract Bark, Rosmarinus Officinalis Oil Leaf Rosemary Oil Leaf, Hydrogenated Lecithin, Chamaecyparis Obtusa Water, Trehalose, Octyldodeceth-16, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, C12-14 Pareth-12, Butylene Glycol, Xanthan Gum, Disodium Edta, Ceramide Np, Fructooligosaccharides, Beta-Glucan, Hydrolyzed Hyaluronic Acid, 4-Terpineol, Glycyrrhiza Glabra Root Rhizome Licorice Root Rhizome, Moringa Oleifera Seed Oil, Glycolic Acid, Salicylic Acid, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- France: https://lovi.care/skincare/fr/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin (this page)
- Spain: https://lovi.care/skincare/es/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/axis-y/spot-the-difference-blemish-treatment/for/oily-skin