# AXIS-Y Dark Spot Correcting Glow Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [AXIS-Y](https://lovi.care/skincare/nl/brands/axis-y)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- This serum offers excellent brightening and evening of skin tone for your combination skin, as niacinamide and glutathione effectively target dark spots and inflammation associated with acne and blemishes.
- The inclusion of sodium hyaluronate and squalane provides essential hydration and barrier support, complementing the active ingredients without overwhelming combination skin.
- The formulation is safe for your skin, with no harsh ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Squalane, Hippophae Rhamnoides Fruit Extract, Glutathione, Rice Bran Extract

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Glutathione at 500 mg/day orally or 2.0% topically may brighten skin color in sun-exposed areas measured by melanin index, though current evidence remains inconclusive. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30895708/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of a sea buckthorn fruit extract formulation significantly reduced skin sebum secretion in 10 healthy human volunteers compared to the control base over an 8-week period. ([Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/))
- Topical emulsions containing Hippophae rhamnoides and Cassia fistula plant extracts significantly reduced skin sebum contents compared to placebo in patients with grade I and grade II acne vulgaris. ([Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/))
- Topical application of a 5% Hippophae rhamnoides oil-in-water emulsion significantly improved skin hydration (p=0.0003) and transepidermal water loss (p=0.0087) compared to a placebo base formulation in 13 healthy male subjects over 84 days. ([Pakistan Journal of Pharmaceutical Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25362595/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation. ([American Journal of Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/15862509/))
- Topical gel and cream formulations containing niosomes entrapped with rice bran bioactive compounds improved skin hydration, lightening, thickness, roughness, and elasticity in 30 human volunteers over 28 days compared to baseline. ([Pharmaceutical Biology, 2012](https://pubmed.ncbi.nlm.nih.gov/22235888/))
- Gel and cream formulations containing rice bran bioactive compounds entrapped in niosomes increased in vitro antioxidant activity (ORAC values of 20-28 micromol TE/g versus 16-18 micromol TE/g for placebo), enhanced lipid peroxidation inhibition in human sebum by about 1.5 times, and improved in vivo human skin hydration by approximately 3 to 30% depending on the measurement technique. ([Journal of Nanoscience and Nanotechnology, 2011](https://pubmed.ncbi.nlm.nih.gov/21449379/))
- Stirring Nukadoko fermented rice bran beds by hand leads to temporary settlement of microorganisms on human skin with quick shedding. ([FEMS Microbiology Letters, 2023](https://pubmed.ncbi.nlm.nih.gov/37960971/))

## What reviewers say

Based on a very large amount of data, this lightweight serum is highly recommended for acne-prone and sensitive skin, effectively calming redness and gradually fading post-acne marks without causing irritation. It also hydrates and brightens the complexion. Users should note that consistent, long-term application is necessary to see significant results on dark spots, and it may not be potent enough for older or deeper hyperpigmentation.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Fades acne marks (often mentioned)
- Liked: Gentle on sensitive skin (often mentioned)
- Disliked: Slow results (often mentioned)
- Liked: Brightens complexion (sometimes noted)
- Liked: Layers well (sometimes noted)
- Disliked: Ineffective for old scars (sometimes noted)
- Disliked: Breakouts (rare) (rarely noted)
- Disliked: Herbal scent (rarely noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes AXIS-Y Dark Spot Correcting Glow Serum a great fit for acne-prone skin?

This serum is a great fit because niacinamide and glutathione help fade dark spots and calm inflammation, while squalane and sodium hyaluronate add lightweight moisture. Its gentle formulation is safe and unlikely to irritate acne-prone skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for acne-prone skin because niacinamide and glutathione target dark spots and inflammation, while squalane and sodium hyaluronate provide lightweight hydration without overwhelming your skin. It also has a safe formulation with no harsh ingredients that could cause irritation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### What does Squalane do for acne-prone skin?

Squalane may help keep acne-prone skin soft and smooth, but peroxidated forms can trigger inflammation in skin cells. For a better fit on acne-prone skin, products need non-clogging, soothing ingredients that balance oil without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in your evening routine, as treatments with active ingredients are placed at night for simplicity and extra safety around sun exposure. The formula contains niacinamide and squalane to help brighten dark spots and keep acne-prone skin hydrated and calm without feeling overwhelmed.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this serum with retinol, and in what order?

You can use this serum alongside a retinol, applying the serum after your retinol and before your moisturizer to help keep acne-prone skin calm and hydrated. Using a gentle routine with this approach is unlikely to cause irritation and may help reduce dark spots and redness.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This treatment serum works best in your evening routine for simplicity and extra safety around sun exposure. You can use it daily, as the gentle formula with niacinamide and squalane is safe and unlikely to cause irritation on acne-prone skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit and is unlikely to cause breakouts on acne-prone skin because it relies on lightweight hydrators like squalane that support your skin without overwhelming it. Reviewers rarely report breakouts, and the formula avoids harsh ingredients that could cause irritation.
Sources: [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.80 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/nl/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/acne-prone-skin) — Superior fit — €99.41 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/nl/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €19.20 at Amazon

## Where to buy

- Amazon.nl: €34.05 (https://www.amazon.nl/dp/B0FX3MXMBJ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €19.00 (https://www.lookfantastic.nl/p/axis-y-dark-spot-correcting-glow-serum-50ml/17735052/)
Prices checked 10 Oct – 5 Nov 2026.

## Ingredients

Water, Glycerin, Niacinamide, Sodium Hyaluronate, Propanediol, Erythritol, Butylene Glycol, Squalane, Rice Bran Extract, Calendula Officinalis Flower Extract, Carica Papaya Fruit Extract, Hippophae Rhamnoides Fruit Extract, Acerola Fruit Extract, Polyglyceryl-10 Laurate, Chlorphenesin, Arginine, Ethylhexylglycerin, Carbomer, Glutathione, 1,2-Hexanediol, Hydroxypropyl Cyclodextrin, Disodium Edta, Hydroxyethylcellulose, Allantoin, Rosmarinus Officinalis Oil Leaf Rosemary Oil Leaf
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin (this page)
- Spain: https://lovi.care/skincare/es/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/axis-y/dark-spot-correcting-glow-serum/for/acne-prone-skin