# Avène Cleanance Comedomed for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Avène](https://lovi.care/skincare/nl/brands/avene)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate exfoliation for your normal skin due to salicylic acid and glycolic acid, which help reduce blemishes, but it lacks sufficient emollient ingredients like glycerin and pumpkin seed oil to fully address potential dryness.
- The presence of glycerin and dipotassium glycyrrhizate provides general hydration and soothing benefits that support your redness and irritation, though they are not targeted for significant improvement.
- The product is safe for your sensitive skin as it lacks prohibited or harsh ingredients, minimizing the risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/oily-acne-prone-skin): High

## Key ingredients

Salicylic Acid, Glycolic Acid, Zinc Gluconate, Silybum Marianum Fruit Extract, Pumpkin Seed Oil

## What the research says

- Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/))
- The use of a salicylic acid-based dermocosmetic significantly reduces the needed quantity of benzoyl peroxide without impacting efficacy in mild to moderate acne, and as maintenance post-benzoyl peroxide allows a significant reduction of acne relapse compared to vehicle. ([Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients. ([Journal of the American Academy of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20488582/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- A dermocosmetic cream containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis significantly decreased inflammatory, non-inflammatory, and total lesion counts in subjects with mild to moderate acne compared to untreated hemi-faces after 15 days. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41487026/))
- Daily use of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% significantly reduced total lesion count by 56.3% after 84 days in 35 subjects with mild to moderate truncal acne. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/))
- Different strains of Propionibacterium acnes modulate cutaneous innate immunity with varying pro-inflammatory potentials, with P. acnes type III showing the highest and P. avidum the weakest, and zinc gluconate down-regulates the expression of most induced immune markers. ([Experimental Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23947673/))
- Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37675655/))
- Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36204969/))
- Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris. ([Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/))
- Topical treatment with pumpkin seed oil healed uniform wounds in rats, achieving full re-epithelialization, reappearance of skin appendages, and well-organized collagen fibers compared to untreated controls. ([Lipids in Health and Disease, 2016](https://pubmed.ncbi.nlm.nih.gov/27068642/))
- A combinational sunscreen formulation of UV filters, melatonin, and pumpkin seed oil ameliorated UV radiation-induced photoaging in adult Wistar albino rats by increasing SOD, GSH-Px, CAT, and collagen levels, while decreasing skin edema, skin thickness, and inflammatory cytokines compared to UV-exposed controls. ([European Journal of Pharmaceutical Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/30414837/))
- Topical pumpkin seed oil increased hair follicle proliferation in mice without causing liver toxicity, oxidative stress, or genotoxicity. ([Acta Histochemica, 2022](https://pubmed.ncbi.nlm.nih.gov/35447441/))

## What reviewers say

This treatment is frequently praised for its effectiveness on oily, blemish-prone, and sensitive skin, particularly in managing blackheads and closed comedones, with many users reporting clearer skin and fewer breakouts. A significant number of users also appreciate its lightweight texture and matte finish. Some users note a strong chemical scent and a drying effect, with a few experiencing irritation or a sticky consistency.

- Liked: Reduces blemishes (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Strong chemical scent (often mentioned)
- Liked: Matte finish (sometimes noted)
- Liked: Prevents recurrence (sometimes noted)
- Disliked: Drying effect (sometimes noted)
- Disliked: Can cause irritation (rarely noted)
- Disliked: Sticky consistency (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Avene Cleanance work for sensitive skin?

This treatment works reasonably well for sensitive skin by offering moderate exfoliation to help clear blemishes while maintaining a safe profile. However, it lacks sufficient moisturizing ingredients like glycerin and pumpkin seed oil to fully prevent potential dryness. A treatment for sensitive skin needs extra hydrating components, strong antioxidants, and skin-repairing ingredients that soothe redness without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/)

### Which ingredients make this treatment a good fit for sensitive skin?

This treatment works for your sensitive skin because glycerin and dipotassium glycyrrhizate provide general hydration and soothing benefits that support redness and irritation. Salicylic acid and glycolic acid also offer moderate exfoliation to help reduce blemishes safely. To be a better fit for this skin, a product of this type needs more soft and nourishing ingredients like niacinamide, snail secretion filtrate, and extra glycerin to fully prevent dryness.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/)

### What does Salicylic Acid do for sensitive skin?

Salicylic acid may cause irritation on sensitive skin, so it requires careful use and good sun protection to keep skin comfortable. A product for this skin type needs gentle, soothing ingredients and a mild formula that respects the skin barrier.
Sources: [The British Journal of Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10233334/), [International Journal of Toxicology, 2003](https://pubmed.ncbi.nlm.nih.gov/14617432/)

### What does Glycolic Acid do for sensitive skin?

Glycolic acid can be too harsh for sensitive skin, leaving it dry and irritated, so this type of skin needs a gentler exfoliating ingredient and calming plant extracts to keep the skin barrier safe and comfortable.
Sources: [Cutaneous and Ocular Toxicology, 2022](https://pubmed.ncbi.nlm.nih.gov/35920724/)

### Where does this treatment go in a skincare routine for sensitive skin?

This treatment goes in the evening routine for sensitive skin, starting at once a week and increasing carefully if your skin tolerates it well.

### Can I use this treatment with retinol, and in what order?

Using this treatment with retinol may cause too much irritation on sensitive skin, so you should use them on alternate nights or apply retinol only after your skin has fully adjusted. When using both, apply this treatment first on clean skin, let it absorb, and follow with a soothing moisturizer to keep skin soft and calm. To work best for sensitive skin, a product of this type needs extra soothing and softening ingredients like plant oils and heavy moisturizers to prevent dryness.

### How often should I use this treatment?

You can start using this treatment once a week in the evening, and if your skin feels comfortable and handles it well, you may carefully use it more often. This product works for your sensitive skin, though it needs more rich, softening ingredients like glycerin and pumpkin seed oil to fully prevent potential dryness.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/)

### Can this treatment clog pores, cause breakouts or purging for sensitive skin?

This treatment is unlikely to clog pores or cause breakouts for sensitive skin because it helps clear blemishes with salicylic acid and glycolic acid, though it may cause some dryness. Sensitive skin of this type needs extra soothing and softening ingredients like glycerin and pumpkin seed oil to prevent dry, tight patches while clearing blemishes.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/)

### Is this treatment fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €160.00 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €35.50 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/nl/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — €19.00 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/nl/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €21.95 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/nl/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €17.96 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/nl/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — €19.79 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Proylene Glycol, Glycerin, Cetearyl Alcohol, Cetearyl Glucoside, Glyceryl Stearate, Peg-100 Stearate, Silica, Dimethicone, Bht, Caprylic Capric Triglyceride, Pumpkin Seed Oil, Sodium Hydroxide, Sodium Polyacrylate, Sodium Stearoyl Glutamate, Zinc Gluconate, Capryloyl Glycine, Citric Acid, Parfum, Disodium Edta, Sodium Benzoate, Potassium Sorbate, Glyceryl Laurate, Monolaurin, Silybum Marianum Fruit Extract, Butylene Glycol, Silymarin, Dipotassium Glycyrrhizate, Tocopherol, Glycolic Acid, Salicylic Acid, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/avene/cleanance-comedomed/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/avene/cleanance-comedomed/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/avene/cleanance-comedomed/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/avene/cleanance-comedomed/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/avene/cleanance-comedomed/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/sensitive-skin (this page)
- Spain: https://lovi.care/skincare/es/p/avene/cleanance-comedomed/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/avene/cleanance-comedomed/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/avene/cleanance-comedomed/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/avene/cleanance-comedomed/for/sensitive-skin