# Anua Heartleaf 70% Daily Relief Lotion for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Anua](https://lovi.care/skincare/nl/brands/anua)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing for your normal skin, with Glycerin and Sodium Hyaluronate providing excellent hydration and plumping effects, though it does not specifically target your wrinkles and fine lines.
- The inclusion of Phytosqualane and Shea Butter further supports emollient action, beneficial for maintaining overall skin health.
- The product is safe for your normal skin, as it contains soothing ingredients like Houttuynia Cordata Extract and Centella Asiatica Extract and lacks harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/oily-acne-prone-skin): Average

## Key ingredients

Heartleaf Extract, Glycerin, Sodium Hyaluronate, Centella Asiatica Extract, Amaranthus Caudatus Seed Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Application of fullerene-C60 dissolved in squalane cream twice daily for 8 weeks significantly enhanced skin moisture and reduced wrinkle formation compared to placebo in 23 Japanese women without severe side effects. ([Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- A single use of an alpha-tocopherol-enriched rinse-off product strongly increases alpha-tocopherol levels in skin barrier lipids maintained for at least 24 hours and significantly inhibits squalene photooxidation in human volunteers compared to a control product. ([Skin Pharmacology and Physiology, 2005](https://pubmed.ncbi.nlm.nih.gov/15608499/))
- Topical treatment with a mixed RetinSphere - vitamin E formulation significantly decreased lipid peroxidation levels and oxidized squalene percentage, reduced interleukin-1α concentration in lesional areas, and led to clinical improvement in 18 patients with mild comedonal acne. ([Journal of the European Academy of Dermatology and Venereology, 2014](https://pubmed.ncbi.nlm.nih.gov/24628899/))
- The investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams showed no skin irritation and provided increased skin hydration and reduced transepidermal water loss in 76 healthy volunteers. ([Vojnosanitetski Pregled, 2016](https://pubmed.ncbi.nlm.nih.gov/29328637/))

## Why other moisturizers fit mature skin better

- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement. ([Nanomaterials, 2024](https://pubmed.ncbi.nlm.nih.gov/38668218/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))

## What reviewers say

Based on a very large amount of data, this lotion is widely praised as a lightweight, fragrance-free moisturizer that excels at soothing redness and calming sensitive or acne-prone skin without clogging pores. While it provides a "glass skin" finish and balances oil for combination types, users with dry skin often find it insufficient on its own, requiring layering or a heavier cream for adequate hydration.

- Liked: Lightweight and non-greasy (mostly mentioned)
- Liked: Soothing and calming (often mentioned)
- Disliked: Not moisturizing enough (often mentioned)
- Liked: Fragrance-free (sometimes noted)
- Liked: Hygienic pump packaging (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Price vs. volume (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does ANUA Heartleaf 70% Daily Relief Lotion work for mature skin?

This lotion works moderately well for mature skin, keeping it hydrated with glycerin and sodium hyaluronate while soothing it with heartleaf and centella asiatica extracts, though it does not target wrinkles and fine lines. To better suit mature skin, a product of this type needs powerful anti-aging ingredients like peptides and antioxidants alongside rich soothing and hydrating components to smooth lines and maintain a healthy moisture balance.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this lotion a good fit for mature skin?

Glycerin and Sodium Hyaluronate provide hydration and plumping effects, while Phytosqualane and Shea Butter help keep skin soft and healthy. To be a better fit for mature skin, a product of this type needs potent ingredients that address wrinkles and fine lines along with peptides and antioxidants.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Heartleaf Extract do for mature skin?

Heartleaf Extract helps calm mature skin and protects it from daily stress by fighting off harmful free radicals and reducing redness. Studies show it supports skin health through strong antioxidant and anti-inflammatory properties.
Sources: [Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39683560/), [Free Radical Biology & Medicine, 2026](https://pubmed.ncbi.nlm.nih.gov/41242472/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this lotion go in a skincare routine for mature skin?

This lotion goes as a moisturizer in the morning routine, and after your treatment in the evening routine. To better suit mature skin, this type of product also needs ingredients that target fine lines and wrinkles.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this lotion with retinol, and in what order?

You can use this lotion with retinol by applying it as your moisturizer step after your treatment, which helps keep your skin comfortable. Mature skin often needs a product that specifically targets wrinkles and fine lines, along with extra firming and anti-aging ingredients.

### How often should I use this lotion?

You can use this moisturizing treatment twice a day as part of your morning and evening routine to keep your skin hydrated and calm. Regular daily application helps maintain moisture and overall skin health.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this lotion clog pores, cause breakouts or purging for mature skin?

This lotion is unlikely to clog pores or cause breakouts for mature skin, as it has a low complaint rate for causing breakouts and contains soothing ingredients like Centella Asiatica Extract. However, because it is an average fit for mature skin, a product for this skin needs richer anti-aging ingredients and targeted wrinkle-smoothing benefits.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can I use this lotion around the eyes or on my body?

You can use this lotion on your body, but the thin skin around your eyes requires a specialized eye cream with targeted anti-aging ingredients like hyaluronic acid and botanical extracts to effectively smooth fine lines. While the lotion provides good moisture, mature skin benefits more from formulas designed to specifically firm and address wrinkles.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this lotion fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/nl/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €69.99 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/nl/p/the-ordinary/natural-moisturizing-factors-ha/for/mature-skin) — High fit — €13.02 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Cream](https://lovi.care/skincare/nl/p/missha/super-aqua-ultra-hyalron-cream/for/mature-skin) — High fit — €39.42 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €14.70 at Amazon

## Where to buy

- Amazon.nl: €16.44 (https://www.amazon.nl/dp/B0CTHK42NM?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Houttuynia Cordata Extract, Glycerin, Caprylic Capric Triglyceride, Cetearyl Alcohol, Butylene Glycol, 1,2-Hexanediol, Phytosqualane, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Centella Asiatica Extract, Ficus Carica Fruit Extract, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Hydrogenated Lecithin, Sodium Hyaluronate, Glyceryl Stearate, Cetearyl Glucoside, Water, Sodium Stearoyl Glutamate, Carbomer, Butyrospermum Parkii Butter Shea Butter, Arginine, Fructooligosaccharides, Beta-Glucan, Glucose, Hydrolyzed Hyaluronic Acid, Ceramide Np, Sodium Acetylated Hyaluronate, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- France: https://lovi.care/skincare/fr/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/heartleaf-70-daily-relief-lotion/for/mature-skin