AMOREPACIFIC Time Response Skin Reserve Serum for mature skin

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Questions and answers

What the research says

• Topical and in vitro application of a Camellia sinensis leaf extract demonstrated immunomodulatory, detoxification, anti-inflammatory, and antioxidant properties while improving mood states, skin hydration, barrier function, rejuvenation, and facial skin health.

  International Journal of Cosmetic Science, 2025

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of (-)-epigallocatechin-3-gallate (EGCG) to human skin before UV irradiation decreases UV-induced production of hydrogen peroxide by 68-90% and nitric oxide by 30-100%, inhibits leukocyte infiltration and lipid peroxidation by 41-84%, and restores glutathione levels and glutathione peroxidase activity compared to UV exposure alone.

  Carcinogenesis, 2001

• Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction.

  Journal of Clinical and Diagnostic Research, 2017

• Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.

  Experimental Dermatology, 2009

• An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.

  Clinical, Cosmetic and Investigational Dermatology, 2019

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

  Rejuvenation Research, 2015

• A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

  Journal of Ginseng Research, 2022

• A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

  Journal of Toxicology and Environmental Health. Part A, 2020

• Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.

  Evidence-based Complementary and Alternative Medicine, 2015

• Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.

  Experimental Dermatology, 2015

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

Ingredients

Camellia Sinensis Leaf Water, Butylene Glycol, Water, Glycerin, Alcohol, Trehalose, Phyllostachis Bambusoides Juice, Glycereth-26, Hydrogenated Poly C6-14 Olefin, Dimethicone, Hydrogenated Lecithin, Propanediol, Pentaerythrityl Tetraethylhexanoate, Polymethylsilsesquioxane, Panthenol, Cetearyl Olivate, 1,2-Hexanediol, Peg-5 Rapeseed Sterol, Sorbitan Olivate, Sodium Polyacrylate, Hydrogenated Polydecene, Parfum, Ammonium Acryloyldimethyltaurate Vp Copolymer, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Tromethamine, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Adenosine, Disodium Edta, Ethylhexylglycerin, Beta-Glucan, Ppg-5-Laureth-5, Glycine Soja Seed Extract Soybean Seed Extract, Natto Gum, Dextrin, Theobroma Cacao Extract, Camellia Sinensis Leaf Extract, Phenoxyethanol, Poloxamer 235, Betaine, Ethoxydiglycol, Epigallocatechin Gallate, Camellia Sinensis Flower Extract, Tocophersolan, Poloxamer 338, Panax Ginseng Root Extract, Glucose, Acetic Acid, Potassium Hydroxide, Caprylyl Glycol, Tocopherol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.