# 47 Skin Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/47-skin/serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [47 Skin](https://lovi.care/skincare/nl/brands/47-skin)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers general hydration for your normal skin due to glycerin, but azelaic acid provides only moderate treatment for blemishes and lacks specialized ingredients to effectively target wrinkles and fine lines.
- The formula is highly suitable for normal skin due to glycerin's humectant action and azelaic acid's mild anti-inflammatory and keratolytic effects.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/47-skin/serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/47-skin/serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/47-skin/serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/47-skin/serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/47-skin/serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/47-skin/serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/47-skin/serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/47-skin/serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/47-skin/serum/for/oily-acne-prone-skin): Average

## Key ingredients

Silver Chitoderm, Azelaic Acid, Glycerin, Dimethicone

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical administration of 20% azelaic acid cream and 5% tranexamic acid solution comparably improved acne-related postinflammatory hyperpigmentation in patients with acne vulgaris, while tranexamic acid demonstrated a significantly better safety profile at week 4. ([Journal of Research in Medical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/37213446/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate. ([Skin Research and Technology, 2000](https://pubmed.ncbi.nlm.nih.gov/11428946/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

Based on a very large amount of data, this serum is highly effective for clearing active breakouts and fading acne scars without causing dryness. Thousands of users report significant improvements in acne and redness, with many experiencing their clearest skin. A smaller number of users found it ineffective for hormonal acne or saw no visible changes. The product is also noted for its hydrating properties and pleasant texture, though some find it expensive for the size and a few sensitive-skinned individuals experienced irritation from the scent.

- Liked: Clears breakouts (mostly mentioned)
- Liked: Fades scarring (often mentioned)
- Liked: Hydrating, non-drying (often mentioned)
- Liked: Pleasant texture (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Ineffective for some (rarely noted)
- Disliked: Irritation/scent (rarely noted)
- Disliked: Subscription issues (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does 47 SKIN Serum work for mature skin?

This serum works for mature skin by providing general hydration, but it offers only moderate care for blemishes and lacks specialized ingredients to target wrinkles and fine lines. A product of this type needs high-quality anti-aging ingredients, potent antioxidants, peptides, and skin-repairing components to effectively smooth and firm mature skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Glycerin helps keep your mature skin hydrated, while azelaic acid provides mild care for blemishes. To truly fit mature skin, a product of this type needs powerful antioxidants, peptides, and specialized ingredients that effectively target wrinkles and fine lines while improving skin elasticity.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Silver Chitoderm do for mature skin?

Silver Chitoderm helps keep skin hydrated and is safe to use on mature skin without causing irritation. This type of product needs soothing ingredients like chamomile and protective barriers to maintain smooth skin and support overall skin health as it ages.
Sources: [Revista Latino-americana de Enfermagem, 2018](https://pubmed.ncbi.nlm.nih.gov/30517572/)

### What does Azelaic Acid do for mature skin?

Azelaic acid helps mature skin by targeting dark spots and uneven tone, while supporting smoother texture and a more youthful look. It provides antioxidant benefits that may reduce signs of aging and protect skin from environmental stress.
Sources: [Frontiers in Medicine, 2026](https://pubmed.ncbi.nlm.nih.gov/42023095/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/36056802/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in your evening routine, as treatments with active ingredients are placed at night for simplicity and extra safety around sun exposure. Mature skin of this type also needs specialized anti-aging ingredients and firming peptides to effectively target wrinkles and fine lines.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying the serum first in your evening routine and following with your retinol. Because this formula is gentle and lacks harsh ingredients, it is unlikely to cause irritation when combined.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This serum fits into your routine in the evening, which keeps things simple and provides extra safety around sun exposure. Because this is a treatment product for mature skin, a product of this type needs specialized ingredients to effectively target wrinkles and fine lines.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clog pores on mature skin due to the absence of harsh or heavy ingredients. To better address mature skin, a product of this type needs specialized ingredients that target wrinkles and fine lines.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €160.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €35.50 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — €419.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

- Amazon.nl: €33.73 (https://www.amazon.nl/dp/B09VQ6JLGR?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Cyclopentasiloxane, Caprylic Capric Triglyceride, Dimethicone, Glyceryl Stearate, Peg-100 Stearate, Cetearyl Alcohol, Silver Chitoderm, Azelaic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/47-skin/serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/47-skin/serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/47-skin/serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/47-skin/serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/47-skin/serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/47-skin/serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/47-skin/serum/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/47-skin/serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/47-skin/serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/47-skin/serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/47-skin/serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/47-skin/serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/47-skin/serum/for/mature-skin