# Vitamin E and hexapeptide

Page: https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Work well together

Use them together in the same routine, applying the [vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e) product first and the [hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide) product second, because they help each other work better. Vitamin E protects the hexapeptide from breaking down, while the hexapeptide helps smooth out fine lines for better anti-aging results. The shopper can use standard strengths and apply them right after each other without waiting.

- [All about vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e)
- [All about hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide)

### [Vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e) products

- [Rhode Glazing Milk](https://lovi.care/skincare/nl/p/rhode/glazing-milk/for/dry-skin) — Superior fit
- [Olay Regenerist Micro-Sculpting Cream](https://lovi.care/skincare/nl/p/olay/regenerist-micro-sculpting-cream/for/mature-skin) — Superior fit — [€54.97 at Amazon](https://www.amazon.nl/dp/B00AZHHMLS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [The Ordinary Azelaic Acid Suspension 10%](https://lovi.care/skincare/nl/p/the-ordinary/azelaic-acid-suspension-10/for/acne-prone-skin) — High fit — [€14.00 at Amazon](https://www.amazon.nl/dp/B0BBLZ2YBP?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Olay Super Serum](https://lovi.care/skincare/nl/p/olay/super-serum/for/dry-skin) — High fit — [€192.17 at Amazon](https://www.amazon.nl/dp/B0HD7BBPY7?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Palmer's Cocoa Butter](https://lovi.care/skincare/nl/p/palmer-s/cocoa-butter/for/dry-skin) — Average fit
- [Caudalie Vinoperfect Radiance Serum](https://lovi.care/skincare/nl/p/caudalie/vinoperfect-radiance-serum/for/dry-skin) — Average fit
- [Aquaphor Lip Repair](https://lovi.care/skincare/nl/p/aquaphor/lip-repair/for/dry-skin) — Superior fit
- [Clinique Take The Day Off Cleansing Balm](https://lovi.care/skincare/nl/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit — [€46.99 at Amazon](https://www.amazon.nl/dp/B09TWCDV9T?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [EltaMD UV Clear Broad-Spectrum SPF 46](https://lovi.care/skincare/nl/p/eltamd/uv-clear-broad-spectrum-spf-46/for/oily-acne-prone-skin) — Superior fit — [€77.06 at Amazon](https://www.amazon.nl/dp/B00ZPWR0N8?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Cetaphil Moisturizing Lotion](https://lovi.care/skincare/nl/p/cetaphil/moisturizing-lotion/for/sensitive-skin) — Average fit — [€28.97 at Amazon](https://www.amazon.nl/dp/B0B3JC1T2Y?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Bio-Oil Skincare Oil](https://lovi.care/skincare/nl/p/bio-oil/skincare-oil/for/dry-skin) — Average fit — [€13.55 at Amazon](https://www.amazon.nl/dp/B00KWCQHZ8?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [NIVEA MEN Sensitive Post Shave Balm](https://lovi.care/skincare/nl/p/nivea-men/sensitive-post-shave-balm/for/sensitive-skin) — Superior fit

### [Hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/nl/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€155.25 at Lookfantastic](https://www.lookfantastic.nl/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/)

## Questions and answers

### Can you use vitamin E and hexapeptide together?

Yes, [vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e) and [hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide) work well together because antioxidants stabilize peptides and enhance anti-aging performance. This combination helps provide synergistic protection against oxidative degradation, making it beneficial for mature, photoaged, and stressed skin.

### Which goes first, vitamin E or hexapeptide?

Vitamin E and hexapeptide work well together, as antioxidants like vitamin E stabilize peptides and enhance anti-aging performance.

### Are vitamin E and hexapeptide good for sensitive skin?

Vitamin E and hexapeptide work well together, as antioxidants stabilize peptides and enhance anti-aging performance. Lovi rates this combination as Superior for mature, photoaged, and stressed skin.

## Research on vitamin E and hexapeptide

- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Vitamin E · Journal of Cosmetic Dermatology, 2020
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin](https://pubmed.ncbi.nlm.nih.gov/12521598/) Vitamin E · Free Radical Biology & Medicine, 2003
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin E · Journal of Cosmetic Dermatology, 2020
- [Tocotrienol-rich fraction attenuates UV-induced inflammaging: A bench to bedside study](https://pubmed.ncbi.nlm.nih.gov/28952200/) Vitamin E · Journal of Cosmetic Dermatology, 2018
- [Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)](https://pubmed.ncbi.nlm.nih.gov/21917024/) Vitamin E · Journal of the European Academy of Dermatology and Venereology, 2012
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin E · Journal of Cosmetic Dermatology, 2022
- [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin E · Journal of Cosmetic Dermatology, 2022
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Vitamin E · Arzneimittel-Forschung, 1998
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin E · Journal of Cosmetic Dermatology, 2024
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Vitamin E · Scientific Reports, 2025
- [Sustained effect of two antioxidants (oxothiazolidine and δ-tocopheryl glucoside) for immediate and long-term sun protection in a sunscreen emulsion based on their different penetrating properties](https://pubmed.ncbi.nlm.nih.gov/33848378/) Vitamin E · International Journal of Cosmetic Science, 2021
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Vitamin E · Contemporary Clinical Trials Communications, 2021

## Other combinations

- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-vitamin-a)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-hyaluronic-acid)
- Work well together: [Vitamin E and hyaluronic acid](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Retinol and vitamin E](https://lovi.care/skincare/nl/ingredients/retinol-and-vitamin-e)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Work well together: [Bio-placenta peptides and vitamin E](https://lovi.care/skincare/nl/ingredients/bio-placenta-peptides-and-vitamin-e)
- Work well together: [Vitamin E and collagen peptide](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-collagen-peptide)
- Work well together: [Vitamin E and copper peptide](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-copper-peptide)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Vitamin E and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4)
- Work well together: [Vitamin E and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-palmitoyl-tripeptide-1)
- Work well together: [Vitamin E and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-peptide-rich-plasma)
- Work well together: [Vitamin E and triple peptide blend](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-triple-peptide-blend)
- Work well together: [Vitamin E and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-tri-ceramide-complex)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Work well together: [AHA blend glycolic and citric acids and vitamin E](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-vitamin-e)
- Work well together: [Vitamin E and citric acid](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-citric-acid)
- Work well together: [Glycolic acid and vitamin E](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-vitamin-e)
- Work well together: [Vitamin E and lactic acid](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-lactic-acid)
- Work well together: [Vitamin E and mandelic acid](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-mandelic-acid)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-copper)
- Work well together: [Niacinamide and vitamin E](https://lovi.care/skincare/nl/ingredients/niacinamide-and-vitamin-e)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide)
- Work well together: [Vitamin C and vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-vitamin-e)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide)
- Work well together: [Salicylic acid and vitamin E](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-vitamin-e)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/vitamin-e-and-hexapeptide
- United Kingdom: https://lovi.care/skincare/uk/ingredients/vitamin-e-and-hexapeptide
- Ireland: https://lovi.care/skincare/ie/ingredients/vitamin-e-and-hexapeptide
- Germany: https://lovi.care/skincare/de/ingredients/vitamin-e-and-hexapeptide
- France: https://lovi.care/skincare/fr/ingredients/vitamin-e-and-hexapeptide
- Italy: https://lovi.care/skincare/it/ingredients/vitamin-e-and-hexapeptide
- Netherlands: https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide (this page)
- Spain: https://lovi.care/skincare/es/ingredients/vitamin-e-and-hexapeptide
- Canada: https://lovi.care/skincare/ca/ingredients/vitamin-e-and-hexapeptide
- Australia: https://lovi.care/skincare/au/ingredients/vitamin-e-and-hexapeptide
- Singapore: https://lovi.care/skincare/sg/ingredients/vitamin-e-and-hexapeptide
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/vitamin-e-and-hexapeptide
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/vitamin-e-and-hexapeptide