# Vitamin E and hexapeptide-9

Page: https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide-9

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Work well together

Use them together in the same routine, applying the [vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e) first and the [hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) right after, because they help each other work better. Vitamin E protects the hexapeptide-9 from breaking down, which helps the peptide smooth out fine lines more effectively. You do not need to change anything since this combination is very gentle for everyday use.

- [All about vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e)
- [All about hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9)

### [Vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e) products

- [Rhode Glazing Milk](https://lovi.care/skincare/nl/p/rhode/glazing-milk/for/dry-skin) — Superior fit
- [Olay Regenerist Micro-Sculpting Cream](https://lovi.care/skincare/nl/p/olay/regenerist-micro-sculpting-cream/for/mature-skin) — Superior fit — [€54.97 at Amazon](https://www.amazon.nl/dp/B00AZHHMLS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [The Ordinary Azelaic Acid Suspension 10%](https://lovi.care/skincare/nl/p/the-ordinary/azelaic-acid-suspension-10/for/acne-prone-skin) — High fit — [€14.00 at Amazon](https://www.amazon.nl/dp/B0BBLZ2YBP?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Olay Super Serum](https://lovi.care/skincare/nl/p/olay/super-serum/for/dry-skin) — High fit — [€192.17 at Amazon](https://www.amazon.nl/dp/B0HD7BBPY7?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Palmer's Cocoa Butter](https://lovi.care/skincare/nl/p/palmer-s/cocoa-butter/for/dry-skin) — Average fit
- [Caudalie Vinoperfect Radiance Serum](https://lovi.care/skincare/nl/p/caudalie/vinoperfect-radiance-serum/for/dry-skin) — Average fit
- [Aquaphor Lip Repair](https://lovi.care/skincare/nl/p/aquaphor/lip-repair/for/dry-skin) — Superior fit
- [Clinique Take The Day Off Cleansing Balm](https://lovi.care/skincare/nl/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit — [€46.99 at Amazon](https://www.amazon.nl/dp/B09TWCDV9T?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [EltaMD UV Clear Broad-Spectrum SPF 46](https://lovi.care/skincare/nl/p/eltamd/uv-clear-broad-spectrum-spf-46/for/oily-acne-prone-skin) — Superior fit — [€77.06 at Amazon](https://www.amazon.nl/dp/B00ZPWR0N8?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Cetaphil Moisturizing Lotion](https://lovi.care/skincare/nl/p/cetaphil/moisturizing-lotion/for/sensitive-skin) — Average fit — [€28.97 at Amazon](https://www.amazon.nl/dp/B0B3JC1T2Y?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Bio-Oil Skincare Oil](https://lovi.care/skincare/nl/p/bio-oil/skincare-oil/for/dry-skin) — Average fit — [€13.55 at Amazon](https://www.amazon.nl/dp/B00KWCQHZ8?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [NIVEA MEN Sensitive Post Shave Balm](https://lovi.care/skincare/nl/p/nivea-men/sensitive-post-shave-balm/for/sensitive-skin) — Superior fit

### [Hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/nl/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€89.95 at Amazon](https://www.amazon.nl/dp/B00175YVOS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/nl/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€10.50 at Notino](https://www.notino.nl/mary-may/6-peptide-complex-intensief-herstellende-serum-met-anti-rimpel-werking/p-16211030/)

## Questions and answers

### Can you use vitamin E and hexapeptide-9 together?

Yes, [vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e) and [hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) work well together to provide synergistic protection against oxidative degradation and enhance anti-aging performance. Antioxidants help stabilize peptides and improve overall skin benefits for mature, photoaged, and stressed skin.

### Which goes first, vitamin E or hexapeptide-9?

Vitamin E and hexapeptide-9 work well together to provide synergistic protection against oxidative degradation for mature, photoaged, and stressed skin.

### Are vitamin E and hexapeptide-9 good for sensitive skin?

Yes, vitamin E and hexapeptide-9 work well together to provide synergistic protection against oxidative degradation, making them beneficial for stressed and mature skin. The combination helps stabilize the ingredients and enhances anti-aging performance.

## Research on vitamin E and hexapeptide-9

- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Vitamin E · Journal of Cosmetic Dermatology, 2020
- [Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin](https://pubmed.ncbi.nlm.nih.gov/12521598/) Vitamin E · Free Radical Biology & Medicine, 2003
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin E · Journal of Cosmetic Dermatology, 2020
- [Tocotrienol-rich fraction attenuates UV-induced inflammaging: A bench to bedside study](https://pubmed.ncbi.nlm.nih.gov/28952200/) Vitamin E · Journal of Cosmetic Dermatology, 2018
- [Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)](https://pubmed.ncbi.nlm.nih.gov/21917024/) Vitamin E · Journal of the European Academy of Dermatology and Venereology, 2012
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin E · Journal of Cosmetic Dermatology, 2022
- [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin E · Journal of Cosmetic Dermatology, 2022
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Vitamin E · Arzneimittel-Forschung, 1998
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin E · Journal of Cosmetic Dermatology, 2024
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Vitamin E · Scientific Reports, 2025
- [Sustained effect of two antioxidants (oxothiazolidine and δ-tocopheryl glucoside) for immediate and long-term sun protection in a sunscreen emulsion based on their different penetrating properties](https://pubmed.ncbi.nlm.nih.gov/33848378/) Vitamin E · International Journal of Cosmetic Science, 2021
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Vitamin E · Contemporary Clinical Trials Communications, 2021
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-hexapeptide-9)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide-9)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Work well together: [Vitamin E and hyaluronic acid](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Retinol and vitamin E](https://lovi.care/skincare/nl/ingredients/retinol-and-vitamin-e)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Work well together: [Bio-placenta peptides and vitamin E](https://lovi.care/skincare/nl/ingredients/bio-placenta-peptides-and-vitamin-e)
- Work well together: [Vitamin E and collagen peptide](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-collagen-peptide)
- Work well together: [Vitamin E and copper peptide](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-copper-peptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4)
- Work well together: [Vitamin E and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-palmitoyl-tripeptide-1)
- Work well together: [Vitamin E and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-peptide-rich-plasma)
- Work well together: [Vitamin E and triple peptide blend](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-triple-peptide-blend)
- Work well together: [Vitamin E and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-tri-ceramide-complex)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Work well together: [AHA blend glycolic and citric acids and vitamin E](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-vitamin-e)
- Work well together: [Vitamin E and citric acid](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-citric-acid)
- Work well together: [Glycolic acid and vitamin E](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-vitamin-e)
- Work well together: [Vitamin E and lactic acid](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-lactic-acid)
- Work well together: [Vitamin E and mandelic acid](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-mandelic-acid)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/copper-and-hexapeptide-9)
- Work well together: [Niacinamide and vitamin E](https://lovi.care/skincare/nl/ingredients/niacinamide-and-vitamin-e)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-sulfate-and-hexapeptide-9)
- Work well together: [Vitamin C and vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-vitamin-e)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide-9)
- Work well together: [Salicylic acid and vitamin E](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-vitamin-e)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/vitamin-e-and-hexapeptide-9
- United Kingdom: https://lovi.care/skincare/uk/ingredients/vitamin-e-and-hexapeptide-9
- Ireland: https://lovi.care/skincare/ie/ingredients/vitamin-e-and-hexapeptide-9
- Germany: https://lovi.care/skincare/de/ingredients/vitamin-e-and-hexapeptide-9
- France: https://lovi.care/skincare/fr/ingredients/vitamin-e-and-hexapeptide-9
- Italy: https://lovi.care/skincare/it/ingredients/vitamin-e-and-hexapeptide-9
- Netherlands: https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide-9 (this page)
- Spain: https://lovi.care/skincare/es/ingredients/vitamin-e-and-hexapeptide-9
- Canada: https://lovi.care/skincare/ca/ingredients/vitamin-e-and-hexapeptide-9
- Australia: https://lovi.care/skincare/au/ingredients/vitamin-e-and-hexapeptide-9
- Singapore: https://lovi.care/skincare/sg/ingredients/vitamin-e-and-hexapeptide-9
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/vitamin-e-and-hexapeptide-9
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/vitamin-e-and-hexapeptide-9