# Vitamin A and hexapeptide-9

Page: https://lovi.care/skincare/nl/ingredients/vitamin-a-and-hexapeptide-9

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Keep them apart

Use them at different times of day, applying [vitamin A](https://lovi.care/skincare/nl/ingredients/vitamin-a) at night and [hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) in the morning, to prevent skin irritation. Using both powerful ingredients at the same time can cause your skin to become red and irritated because they both trigger deep skin renewal. You can easily fix this by applying them at different times of day or switching to a milder vitamin A formula.

- [All about vitamin A](https://lovi.care/skincare/nl/ingredients/vitamin-a)
- [All about hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9)

### [Vitamin A](https://lovi.care/skincare/nl/ingredients/vitamin-a) products

- [Bio-Oil Skincare Oil](https://lovi.care/skincare/nl/p/bio-oil/skincare-oil/for/dry-skin) — Average fit — [€13.55 at Amazon](https://www.amazon.nl/dp/B00KWCQHZ8?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [ZO Skin Health Exfoliating Polish](https://lovi.care/skincare/nl/p/zo-skin-health/exfoliating-polish/for/mature-skin) — High fit
- [Peter Thomas Roth Instant FIRMx Eye Temporary Eye Tightener](https://lovi.care/skincare/nl/p/peter-thomas-roth/instant-firmx-eye-temporary-eye-tightener/for/mature-skin) — High fit — [€31.95 at Amazon](https://www.amazon.nl/dp/B004P2LL2K?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Peter Thomas Roth Instant FirmX Temporary Face Tightener](https://lovi.care/skincare/nl/p/peter-thomas-roth/instant-firmx-temporary-face-tightener/for/mature-skin) — Average fit
- [Augustinus Bader The Cream](https://lovi.care/skincare/nl/p/augustinus-bader/the-cream/for/mature-skin) — High fit — [€229.99 at Amazon](https://www.amazon.nl/dp/B0F15KCJY3?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [U Beauty Resurfacing Compound](https://lovi.care/skincare/nl/p/u-beauty/resurfacing-compound/for/dark-spots) — High fit
- [Philosophy Hope In A Jar](https://lovi.care/skincare/nl/p/philosophy/hope-in-a-jar/for/dark-spots) — Average fit
- [SkinMedica TNS Eye Repair](https://lovi.care/skincare/nl/p/skinmedica/tns-eye-repair/for/mature-skin) — Superior fit
- [Dermalogica Multivitamin Power Recovery Masque](https://lovi.care/skincare/nl/p/dermalogica/multivitamin-power-recovery-masque/for/mature-skin) — High fit
- [BYOMA Sensitive Retinol Oil](https://lovi.care/skincare/nl/p/byoma/sensitive-retinol-oil/for/dry-skin) — Average fit — [€35.00 at Amazon](https://www.amazon.nl/dp/B0CSDWY381?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [NatureWell Extra Virgin Coconut Oil Moisturizing Cream](https://lovi.care/skincare/nl/p/naturewell/extra-virgin-coconut-oil-moisturizing-cream/for/mature-skin) — Average fit
- [Murad Essential-C Cleanser](https://lovi.care/skincare/nl/p/murad/essential-c-cleanser/for/mature-skin) — High fit

### [Hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/nl/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€89.95 at Amazon](https://www.amazon.nl/dp/B00175YVOS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/nl/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€10.50 at Notino](https://www.notino.nl/mary-may/6-peptide-complex-intensief-herstellende-serum-met-anti-rimpel-werking/p-16211030/)

## Questions and answers

### Can you use vitamin A and hexapeptide-9 together?

Keep [vitamin A](https://lovi.care/skincare/nl/ingredients/vitamin-a) and [hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) apart because combining them may increase skin irritation since both ingredients activate skin renewal pathways. Alternate your usage by applying the retinoid in the evening and peptides in the morning.

### Which goes first, vitamin A or hexapeptide-9?

Keep vitamin A and hexapeptide-9 apart because combining them may increase irritation, so use hexapeptide-9 in the morning and vitamin A at night.

### Are vitamin A and hexapeptide-9 good for sensitive skin?

Keep vitamin A and hexapeptide-9 apart in your routine because combining them may increase irritation, especially on sensitive skin. Instead, alternate their usage by applying your retinoid in the evening and peptides in the morning.

## Research on vitamin A and hexapeptide-9

- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Vitamin A · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Vitamin A · The British Journal of Dermatology, 2019
- [Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne](https://pubmed.ncbi.nlm.nih.gov/32210603/) Vitamin A · Clinical, Cosmetic and Investigational Dermatology, 2020
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Vitamin A · International Journal of Nanomedicine, 2021
- [Encapsulation and controlled release of retinol from silicone particles for topical delivery](https://pubmed.ncbi.nlm.nih.gov/29604311/) Vitamin A · Journal of Controlled Release, 2018
- [A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen](https://pubmed.ncbi.nlm.nih.gov/20374604/) Vitamin A · The British Journal of Dermatology, 2010
- [Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system](https://pubmed.ncbi.nlm.nih.gov/21411295/) Vitamin A · Colloids and Surfaces. B, Biointerfaces, 2011
- [A clinicopathological study of the effects of topical retinyl propionate cream in skin photoageing](https://pubmed.ncbi.nlm.nih.gov/9894360/) Vitamin A · Clinical and Experimental Dermatology, 1998
- [The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites](https://pubmed.ncbi.nlm.nih.gov/23438139/) Vitamin A · Journal of Cosmetic Dermatology, 2013
- [Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing](https://pubmed.ncbi.nlm.nih.gov/38685700/) Vitamin A · International Journal of Cosmetic Science, 2024
- [Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation](https://pubmed.ncbi.nlm.nih.gov/28733999/) Vitamin A · International Journal of Cosmetic Science, 2017
- [Microneedling and Topical Retinyl Palmitate for Acne Scars: A Preliminary Split-Face Study with Placebo Control](https://pubmed.ncbi.nlm.nih.gov/41899112/) Vitamin A · Journal of Clinical Medicine, 2026
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Keep them apart: [Bio-placenta peptides and vitamin A](https://lovi.care/skincare/nl/ingredients/bio-placenta-peptides-and-vitamin-a)
- Keep them apart: [Vitamin A and collagen peptide](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-collagen-peptide)
- Keep them apart: [Vitamin A and copper peptide](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-copper-peptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-vitamin-a)
- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Vitamin A and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-palmitoyl-tripeptide-1)
- Keep them apart: [Vitamin A and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-peptide-rich-plasma)
- Keep them apart: [Vitamin A and triple peptide blend](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-triple-peptide-blend)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and vitamin A](https://lovi.care/skincare/nl/ingredients/niacinamide-and-vitamin-a)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/copper-and-hexapeptide-9)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-sulfate-and-hexapeptide-9)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/vitamin-a-and-hexapeptide-9
- United Kingdom: https://lovi.care/skincare/uk/ingredients/vitamin-a-and-hexapeptide-9
- Ireland: https://lovi.care/skincare/ie/ingredients/vitamin-a-and-hexapeptide-9
- Germany: https://lovi.care/skincare/de/ingredients/vitamin-a-and-hexapeptide-9
- France: https://lovi.care/skincare/fr/ingredients/vitamin-a-and-hexapeptide-9
- Italy: https://lovi.care/skincare/it/ingredients/vitamin-a-and-hexapeptide-9
- Netherlands: https://lovi.care/skincare/nl/ingredients/vitamin-a-and-hexapeptide-9 (this page)
- Spain: https://lovi.care/skincare/es/ingredients/vitamin-a-and-hexapeptide-9
- Canada: https://lovi.care/skincare/ca/ingredients/vitamin-a-and-hexapeptide-9
- Australia: https://lovi.care/skincare/au/ingredients/vitamin-a-and-hexapeptide-9
- Singapore: https://lovi.care/skincare/sg/ingredients/vitamin-a-and-hexapeptide-9
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/vitamin-a-and-hexapeptide-9
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/vitamin-a-and-hexapeptide-9