# Tretinoin and hexapeptide

Page: https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Keep them apart

Use them at different times of day by applying your peptide product in the morning and [tretinoin](https://lovi.care/skincare/nl/ingredients/tretinoin) at night to prevent skin irritation. Using both active ingredients at the same time can overwhelm your skin and cause redness or irritation. You can easily fix this by giving your skin more time between applications or using a gentler formula.

- [All about tretinoin](https://lovi.care/skincare/nl/ingredients/tretinoin)
- [All about hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide)

### [Tretinoin](https://lovi.care/skincare/nl/ingredients/tretinoin) products

- [Retin-A Cream](https://lovi.care/skincare/nl/p/retin-a/cream/for/oily-skin) — High fit
- [Tri-Luma Cream](https://lovi.care/skincare/nl/p/tri-luma/cream/for/dark-spots) — Average fit
- [Musely The Spot Cream](https://lovi.care/skincare/nl/p/musely/the-spot-cream/for/mature-skin) — High fit
- [Obagi Tretinoin Cream 0.05%](https://lovi.care/skincare/nl/p/obagi/tretinoin-cream-0-05/for/oily-skin) — High fit
- [Taro Tretinoin Cream](https://lovi.care/skincare/nl/p/taro/tretinoin-cream/for/combination-skin) — High fit
- [Mylan Tretinoin](https://lovi.care/skincare/nl/p/mylan/tretinoin/for/acne-prone-skin) — Average fit
- [Curology Formula](https://lovi.care/skincare/nl/p/curology/formula/for/oily-skin) — High fit
- [Menarini A-Ret Gel](https://lovi.care/skincare/nl/p/menarini/a-ret-gel/for/oily-skin) — High fit

### [Hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/nl/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€155.25 at Lookfantastic](https://www.lookfantastic.nl/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/)

## Questions and answers

### Can you use tretinoin and hexapeptide together?

No, you should keep [tretinoin](https://lovi.care/skincare/nl/ingredients/tretinoin) and [hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide) apart in your routine because combining them may increase irritation. Instead, alternate their usage by applying your retinoid in the PM and peptides in the AM.

### Which goes first, tretinoin or hexapeptide?

Keep tretinoin and hexapeptide apart by alternating usage, using your retinoid in the evening and peptides in the morning. Combining them in the same routine may increase skin irritation because both ingredients actively stimulate dermal remodeling.

### Are tretinoin and hexapeptide good for sensitive skin?

Keep tretinoin and hexapeptide apart in your routine because combined stimulation may increase irritation on sensitive skin. Instead, you can alternate usage by applying your retinoid in the evening and peptides in the morning.

## Research on tretinoin and hexapeptide

- [Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid)](https://pubmed.ncbi.nlm.nih.gov/8336752/) Tretinoin · The New England Journal of Medicine, 1993
- [Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne](https://pubmed.ncbi.nlm.nih.gov/32210603/) Tretinoin · Clinical, Cosmetic and Investigational Dermatology, 2020
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Efficacy assessments of tretinoin-loaded nano lipid carriers in acne vulgaris: a double blind, split-face randomized clinical study](https://pubmed.ncbi.nlm.nih.gov/34146120/) Tretinoin · Archives of Dermatological Research, 2022
- [Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials](https://pubmed.ncbi.nlm.nih.gov/35620028/) Tretinoin · International Journal of Women's Dermatology, 2022
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019

## Other combinations

- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/nl/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and bio-placenta peptides](https://lovi.care/skincare/nl/ingredients/tretinoin-and-bio-placenta-peptides)
- Keep them apart: [Tretinoin and collagen peptide](https://lovi.care/skincare/nl/ingredients/tretinoin-and-collagen-peptide)
- Keep them apart: [Tretinoin and copper peptide](https://lovi.care/skincare/nl/ingredients/tretinoin-and-copper-peptide)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-vitamin-a)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/tretinoin-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Tretinoin and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/tretinoin-and-palmitoyl-tripeptide-1)
- Keep them apart: [Tretinoin and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/tretinoin-and-peptide-rich-plasma)
- Keep them apart: [Tretinoin and triple peptide blend](https://lovi.care/skincare/nl/ingredients/tretinoin-and-triple-peptide-blend)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide)
- Depends on the strength: [Niacinamide and tretinoin](https://lovi.care/skincare/nl/ingredients/niacinamide-and-tretinoin)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide)
- Keep them apart: [AHA blend glycolic and citric acids and tretinoin](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-tretinoin)
- Keep them apart: [Tretinoin and citric acid](https://lovi.care/skincare/nl/ingredients/tretinoin-and-citric-acid)
- Keep them apart: [Glycolic acid and tretinoin](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-tretinoin)
- Keep them apart: [Tretinoin and lactic acid](https://lovi.care/skincare/nl/ingredients/tretinoin-and-lactic-acid)
- Keep them apart: [Tretinoin and mandelic acid](https://lovi.care/skincare/nl/ingredients/tretinoin-and-mandelic-acid)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide)
- Keep them apart: [Salicylic acid and tretinoin](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-tretinoin)
- Keep them apart: [Vitamin C and tretinoin](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-tretinoin)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-copper)
- Keep them apart: [Benzoyl peroxide and tretinoin](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-tretinoin)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/tretinoin-and-hexapeptide
- United Kingdom: https://lovi.care/skincare/uk/ingredients/tretinoin-and-hexapeptide
- Ireland: https://lovi.care/skincare/ie/ingredients/tretinoin-and-hexapeptide
- Germany: https://lovi.care/skincare/de/ingredients/tretinoin-and-hexapeptide
- France: https://lovi.care/skincare/fr/ingredients/tretinoin-and-hexapeptide
- Italy: https://lovi.care/skincare/it/ingredients/tretinoin-and-hexapeptide
- Netherlands: https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide (this page)
- Spain: https://lovi.care/skincare/es/ingredients/tretinoin-and-hexapeptide
- Canada: https://lovi.care/skincare/ca/ingredients/tretinoin-and-hexapeptide
- Australia: https://lovi.care/skincare/au/ingredients/tretinoin-and-hexapeptide
- Singapore: https://lovi.care/skincare/sg/ingredients/tretinoin-and-hexapeptide
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/tretinoin-and-hexapeptide
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/tretinoin-and-hexapeptide