# Retinol and palmitoyl pentapeptide-4 Page: https://lovi.care/skincare/nl/ingredients/retinol-and-palmitoyl-pentapeptide-4 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands. Depends on the strength Use them at different times of day, applying the peptide cream in the morning and the [retinol](https://lovi.care/skincare/nl/ingredients/retinol) at night, because strong retinoids can clash. Retinol speeds up cell turnover while peptides help firm the skin, and they work best when you give your skin a break. You can switch to a gentler retinol strength or wait a little longer between steps if your skin feels irritated. - [All about retinol](https://lovi.care/skincare/nl/ingredients/retinol) - [All about palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/palmitoyl-pentapeptide-4) ### [Retinol](https://lovi.care/skincare/nl/ingredients/retinol) products - [CeraVe Resurfacing Retinol Serum](https://lovi.care/skincare/nl/p/cerave/resurfacing-retinol-serum/for/dark-spots) — High fit — [€22.50 at Notino](https://www.notino.nl/cerave/blemish-control-active-serum-met-ratinol/p-16142856/) - [RoC Retinol Correxion Deep Wrinkle Night Cream](https://lovi.care/skincare/nl/p/roc/retinol-correxion-deep-wrinkle-night-cream/for/dark-spots) — High fit — [€44.90 at Amazon](https://www.amazon.nl/dp/B0FMK54Q87?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Paula's Choice 1% Retinol Treatment](https://lovi.care/skincare/nl/p/paula-s-choice/1-retinol-treatment/for/dark-spots) — Superior fit — [€57.00 at Amazon](https://www.amazon.nl/dp/B07P6M914G?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [RoC Retinol Correxion Line Smoothing Eye Cream](https://lovi.care/skincare/nl/p/roc/retinol-correxion-line-smoothing-eye-cream/for/mature-skin) — High fit — [€18.21 at Amazon](https://www.amazon.nl/dp/B08GGD7NRN?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Good Molecules Gentle Retinol Cream](https://lovi.care/skincare/nl/p/good-molecules/gentle-retinol-cream/for/mature-skin) — High fit - [La Roche-Posay Retinol B3 Serum](https://lovi.care/skincare/nl/p/la-roche-posay/retinol-b3-serum/for/dark-spots) — Average fit — [€35.05 at Amazon](https://www.amazon.nl/dp/B07Z9Y4M3C?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [DRMTLGY Retinol Body Lotion](https://lovi.care/skincare/nl/p/drmtlgy/retinol-body-lotion/for/mature-skin) — Average fit - [RoC Retinol Correxion Deep Wrinkle Serum](https://lovi.care/skincare/nl/p/roc/retinol-correxion-deep-wrinkle-serum/for/oily-skin) — Average fit — [€32.97 at Amazon](https://www.amazon.nl/dp/B0GQZ5J61H?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [CeraVe Skin Renewing Retinol Serum](https://lovi.care/skincare/nl/p/cerave/skin-renewing-retinol-serum/for/dark-spots) — Average fit — [€29.75 at Amazon](https://www.amazon.nl/dp/B0FHPRRNX8?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Olay Regenerist Retinol 24 Night Moisturizer](https://lovi.care/skincare/nl/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin) — Superior fit — [€35.00 at Amazon](https://www.amazon.nl/dp/B0852NRDYN?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [cocokind Retinol Body Cream](https://lovi.care/skincare/nl/p/cocokind/retinol-body-cream/for/mature-skin) — Average fit - [Neutrogena Rapid Wrinkle Repair Regenerating Cream](https://lovi.care/skincare/nl/p/neutrogena/rapid-wrinkle-repair-regenerating-cream/for/mature-skin) — High fit — [€43.99 at Amazon](https://www.amazon.nl/dp/B0725JP4TN?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) ### [Palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/palmitoyl-pentapeptide-4) products - [Olay Eye Lifting Serum](https://lovi.care/skincare/nl/p/olay/eye-lifting-serum/for/dry-skin) — High fit ## Questions and answers ### Can you use retinol and palmitoyl pentapeptide-4 together? Yes, you can use [retinol](https://lovi.care/skincare/nl/ingredients/retinol) and [palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/palmitoyl-pentapeptide-4) together depending on the strength, as they are beneficial when combined to enhance [collagen](https://lovi.care/skincare/nl/ingredients/collagen) synthesis and reduce irritation. You can combine them in layered formulas or alternate their use to build tolerance. ### Which goes first, retinol or palmitoyl pentapeptide-4? Yes, you can use retinol and palmitoyl pentapeptide-4 together, but it depends on the strength. Strong retinoids should be separated from peptides by alternating your usage, such as applying your retinoid in the evening and peptides in the morning, to avoid irritation. ### Are retinol and palmitoyl pentapeptide-4 good for sensitive skin? Using retinol and palmitoyl pentapeptide-4 together depends on the strength, as strong retinoids may increase irritation on sensitive skin. You can alternate usage by applying the retinoid at night and peptides in the morning. ## Research on retinol and palmitoyl pentapeptide-4 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Encapsulation and controlled release of retinol from silicone particles for topical delivery](https://pubmed.ncbi.nlm.nih.gov/29604311/) Retinol · Journal of Controlled Release, 2018 - [A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen](https://pubmed.ncbi.nlm.nih.gov/20374604/) Retinol · The British Journal of Dermatology, 2010 - [Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing](https://pubmed.ncbi.nlm.nih.gov/38685700/) Retinol · International Journal of Cosmetic Science, 2024 - [Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis](https://pubmed.ncbi.nlm.nih.gov/42500768/) Palmitoyl pentapeptide-4 · Cureus, 2026 ## Other combinations - Depends on the strength: [Retinol and niacinamide](https://lovi.care/skincare/nl/ingredients/retinol-and-niacinamide) - Keep them apart: [Retinol and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/retinol-and-isopropyl-alcohol) - Keep them apart: [Retinol and sodium lauryl sulfate](https://lovi.care/skincare/nl/ingredients/retinol-and-sodium-lauryl-sulfate) - Keep them apart: [Retinol and aha blend glycolic and citric acids](https://lovi.care/skincare/nl/ingredients/retinol-and-aha-blend-glycolic-and-citric-acids) - Keep them apart: [Retinol and citric acid](https://lovi.care/skincare/nl/ingredients/retinol-and-citric-acid) - Keep them apart: [Glycolic acid and retinol](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-retinol) - Keep them apart: [Retinol and lactic acid](https://lovi.care/skincare/nl/ingredients/retinol-and-lactic-acid) - Keep them apart: [Retinol and mandelic acid](https://lovi.care/skincare/nl/ingredients/retinol-and-mandelic-acid) - Keep them apart: [Retinol and salicylic acid](https://lovi.care/skincare/nl/ingredients/retinol-and-salicylic-acid) - Keep them apart: [Vitamin C and retinol](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-retinol) - Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/nl/ingredients/retinol-and-acetyl-hexapeptide-3) - Depends on the strength: [Retinol and bio-placenta peptides](https://lovi.care/skincare/nl/ingredients/retinol-and-bio-placenta-peptides) - Depends on the strength: [Retinol and collagen peptide](https://lovi.care/skincare/nl/ingredients/retinol-and-collagen-peptide) - Depends on the strength: [Retinol and copper peptide](https://lovi.care/skincare/nl/ingredients/retinol-and-copper-peptide) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide) - Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide-9) - Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/adapalene-and-palmitoyl-pentapeptide-4) - Keep them apart: [Granactive retinoid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/granactive-retinoid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4) - Keep them apart: [Pro-retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/pro-retinol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/retinal-and-palmitoyl-pentapeptide-4) - Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4) - Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/tretinoin-and-palmitoyl-pentapeptide-4) - Keep them apart: [Vitamin A and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/retinol-and-palmitoyl-tripeptide-1) - Depends on the strength: [Retinol and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/retinol-and-peptide-rich-plasma) - Depends on the strength: [Retinol and triple peptide blend](https://lovi.care/skincare/nl/ingredients/retinol-and-triple-peptide-blend) - Work well together: [Liposome and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/liposome-and-palmitoyl-pentapeptide-4) - Work well together: [Microcapsule and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/microcapsule-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Vitamin C and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-palmitoyl-pentapeptide-4) - Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/betaine-and-palmitoyl-pentapeptide-4) - Work well together: [Glycerin and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/glycerin-and-palmitoyl-pentapeptide-4) - Work well together: [Hyaluronic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/niacinamide-and-palmitoyl-pentapeptide-4) - Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/panthenol-and-palmitoyl-pentapeptide-4) - Work well together: [Bakuchiol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-palmitoyl-pentapeptide-4) - Work well together: [Retinol and bakuchiol](https://lovi.care/skincare/nl/ingredients/retinol-and-bakuchiol) - Work well together: [Retinol and coenzyme q10](https://lovi.care/skincare/nl/ingredients/retinol-and-coenzyme-q10) - Work well together: [Retinol and green tea](https://lovi.care/skincare/nl/ingredients/retinol-and-green-tea) - Work well together: [Retinol and vitamin E](https://lovi.care/skincare/nl/ingredients/retinol-and-vitamin-e) - Work well together: [Arginine and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/arginine-and-palmitoyl-pentapeptide-4) - Work well together: [GABA and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/gaba-and-palmitoyl-pentapeptide-4) - Work well together: [Silk amino acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-palmitoyl-pentapeptide-4) - Work well together: [Taurine and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/taurine-and-palmitoyl-pentapeptide-4) - Work well together: [Palmitoyl pentapeptide-4 and theanine](https://lovi.care/skincare/nl/ingredients/palmitoyl-pentapeptide-4-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-pentapeptide-4) - Keep them apart: [Citric acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/citric-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4) - Work well together: [Coenzyme Q10 and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-palmitoyl-pentapeptide-4) - Work well together: [Green tea and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/green-tea-and-palmitoyl-pentapeptide-4) - Work well together: [Vitamin E and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4) - Work well together: [Beta-sitosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/beta-sitosterol-and-palmitoyl-pentapeptide-4) - Work well together: [Ceramide-building complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-palmitoyl-pentapeptide-4) - Work well together: [Cholesterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/cholesterol-and-palmitoyl-pentapeptide-4) - Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4) - Work well together: [Phytosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/phytosterol-and-palmitoyl-pentapeptide-4) - Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/squalene-and-palmitoyl-pentapeptide-4) - Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4) - Keep them apart: [Salicylic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/baking-soda-and-palmitoyl-pentapeptide-4) - Keep them apart: [Bleach and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/bleach-and-palmitoyl-pentapeptide-4) - Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4) - Keep them apart: [Behenyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/behenyl-alcohol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Isopropyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/isopropyl-alcohol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Polyvinyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/copper-and-palmitoyl-pentapeptide-4) - Keep them apart: [Benzoyl peroxide and retinol](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-retinol) - Keep them apart: [Benzoyl peroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-palmitoyl-pentapeptide-4) - Keep them apart: [Magnesium and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/magnesium-and-palmitoyl-pentapeptide-4) - Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/zinc-and-palmitoyl-pentapeptide-4) - Keep them apart: [Zinc sulfate and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/zinc-sulfate-and-palmitoyl-pentapeptide-4) - Work well together: [Retinol and ceramide-building complex](https://lovi.care/skincare/nl/ingredients/retinol-and-ceramide-building-complex) - Work well together: [Retinol and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/retinol-and-tri-ceramide-complex) - Keep them apart: [Azelaic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/protease-and-palmitoyl-pentapeptide-4) - Keep them apart: [Superoxide dismutase and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/retinol-and-palmitoyl-pentapeptide-4 - United Kingdom: https://lovi.care/skincare/uk/ingredients/retinol-and-palmitoyl-pentapeptide-4 - Ireland: https://lovi.care/skincare/ie/ingredients/retinol-and-palmitoyl-pentapeptide-4 - Germany: https://lovi.care/skincare/de/ingredients/retinol-and-palmitoyl-pentapeptide-4 - France: https://lovi.care/skincare/fr/ingredients/retinol-and-palmitoyl-pentapeptide-4 - Italy: https://lovi.care/skincare/it/ingredients/retinol-and-palmitoyl-pentapeptide-4 - Netherlands: https://lovi.care/skincare/nl/ingredients/retinol-and-palmitoyl-pentapeptide-4 (this page) - Spain: https://lovi.care/skincare/es/ingredients/retinol-and-palmitoyl-pentapeptide-4 - Canada: https://lovi.care/skincare/ca/ingredients/retinol-and-palmitoyl-pentapeptide-4 - Australia: https://lovi.care/skincare/au/ingredients/retinol-and-palmitoyl-pentapeptide-4 - Singapore: https://lovi.care/skincare/sg/ingredients/retinol-and-palmitoyl-pentapeptide-4 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/retinol-and-palmitoyl-pentapeptide-4 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/retinol-and-palmitoyl-pentapeptide-4