# Retinoid blend and hexapeptide-9 Page: https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-hexapeptide-9 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands. Keep them apart Use them at different times of day, applying your retinoid at night and [hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) in the morning to prevent extra skin irritation. Both ingredients work hard to renew your skin, but using them together can cause redness and irritation. You can safely use both by switching to a gentler retinoid or giving your skin more time between applications. - [All about retinoid blend](https://lovi.care/skincare/nl/ingredients/retinoid-blend) - [All about hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) ### [Retinoid blend](https://lovi.care/skincare/nl/ingredients/retinoid-blend) products - [Sunday Riley A+ High-Dose Retinoid Serum](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/oily-acne-prone-skin) — High fit — [€311.09 at Amazon](https://www.amazon.nl/dp/B07T53TFGM?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) ### [Hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) products - [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/nl/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€89.95 at Amazon](https://www.amazon.nl/dp/B00175YVOS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/nl/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit - [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€10.50 at Notino](https://www.notino.nl/mary-may/6-peptide-complex-intensief-herstellende-serum-met-anti-rimpel-werking/p-16211030/) ## Questions and answers ### Can you use retinoid blend and hexapeptide-9 together? No, you should keep [retinoid blend](https://lovi.care/skincare/nl/ingredients/retinoid-blend) and [hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) apart in your routine because combining them may increase irritation since both activate dermal remodeling pathways. Instead, alternate their usage by applying the retinoid in the PM and peptides in the AM. ### Which goes first, retinoid blend or hexapeptide-9? Keep them apart by alternating usage, such as applying your retinoid blend in the PM and hexapeptide-9 in the AM, because combining them may increase irritation. ### Are retinoid blend and hexapeptide-9 good for sensitive skin? Keep retinoid blend and hexapeptide-9 apart in your routine because combining them may increase irritation. Alternate their usage by applying your retinoid in the evening and hexapeptide-9 in the morning, which helps mature and sensitive skin. ## Research on retinoid blend and hexapeptide-9 - [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025 ## Other combinations - Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-retinoid-blend) - Keep them apart: [Bio-placenta peptides and retinoid blend](https://lovi.care/skincare/nl/ingredients/bio-placenta-peptides-and-retinoid-blend) - Keep them apart: [Retinoid blend and collagen peptide](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-collagen-peptide) - Keep them apart: [Retinoid blend and copper peptide](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-copper-peptide) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-retinoid-blend) - Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide-9) - Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/granactive-retinoid-and-hexapeptide-9) - Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9) - Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/pro-retinol-and-hexapeptide-9) - Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinal-and-hexapeptide-9) - Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide-9) - Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide-9) - Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-hexapeptide-9) - Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4) - Keep them apart: [Retinoid blend and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-palmitoyl-tripeptide-1) - Keep them apart: [Retinoid blend and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-peptide-rich-plasma) - Keep them apart: [Retinoid blend and triple peptide blend](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-triple-peptide-blend) - Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/liposome-and-hexapeptide-9) - Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/microcapsule-and-hexapeptide-9) - Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide-9) - Depends on the strength: [Niacinamide and retinoid blend](https://lovi.care/skincare/nl/ingredients/niacinamide-and-retinoid-blend) - Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/betaine-and-hexapeptide-9) - Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide-9) - Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-hexapeptide-9) - Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide-9) - Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide-9) - Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide-9) - Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/arginine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-gaba) - Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-hexapeptide-9) - Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/taurine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9) - Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/citric-acid-and-hexapeptide-9) - Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide-9) - Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-hexapeptide-9) - Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-hexapeptide-9) - Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide-9) - Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide-9) - Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide-9) - Keep them apart: [AHA blend glycolic and citric acids and retinoid blend](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-retinoid-blend) - Keep them apart: [Retinoid blend and citric acid](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-citric-acid) - Keep them apart: [Glycolic acid and retinoid blend](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-retinoid-blend) - Keep them apart: [Lactic acid and retinoid blend](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-retinoid-blend) - Keep them apart: [Mandelic acid and retinoid blend](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-retinoid-blend) - Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide-9) - Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/cholesterol-and-hexapeptide-9) - Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-hexapeptide-9) - Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosterol-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-squalene) - Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide-9) - Keep them apart: [Salicylic acid and retinoid blend](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-retinoid-blend) - Keep them apart: [Vitamin C and retinoid blend](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-retinoid-blend) - Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-baking-soda) - Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bleach-and-hexapeptide-9) - Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-behenyl-alcohol) - Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-isopropyl-alcohol) - Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol-and-hexapeptide-9) - Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/copper-and-hexapeptide-9) - Keep them apart: [Benzoyl peroxide and retinoid blend](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-retinoid-blend) - Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide-9) - Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/magnesium-and-hexapeptide-9) - Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-and-hexapeptide-9) - Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-sulfate-and-hexapeptide-9) - Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-protease) - Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-hexapeptide-9) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/retinoid-blend-and-hexapeptide-9 - United Kingdom: https://lovi.care/skincare/uk/ingredients/retinoid-blend-and-hexapeptide-9 - Ireland: https://lovi.care/skincare/ie/ingredients/retinoid-blend-and-hexapeptide-9 - Germany: https://lovi.care/skincare/de/ingredients/retinoid-blend-and-hexapeptide-9 - France: https://lovi.care/skincare/fr/ingredients/retinoid-blend-and-hexapeptide-9 - Italy: https://lovi.care/skincare/it/ingredients/retinoid-blend-and-hexapeptide-9 - Netherlands: https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-hexapeptide-9 (this page) - Spain: https://lovi.care/skincare/es/ingredients/retinoid-blend-and-hexapeptide-9 - Canada: https://lovi.care/skincare/ca/ingredients/retinoid-blend-and-hexapeptide-9 - Australia: https://lovi.care/skincare/au/ingredients/retinoid-blend-and-hexapeptide-9 - Singapore: https://lovi.care/skincare/sg/ingredients/retinoid-blend-and-hexapeptide-9 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/retinoid-blend-and-hexapeptide-9 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/retinoid-blend-and-hexapeptide-9