# Hexapeptide-9 Page: https://lovi.care/skincare/nl/ingredients/hexapeptide-9 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands. Topical treatment with hexapeptide-9 visibly softens fine lines, smooths rough texture around the eyes and forehead, and generally outperforms [retinol](https://lovi.care/skincare/nl/ingredients/retinol) in healthy volunteers with aging skin. It suits most skin types best and is commonly found in lightweight [serums](https://lovi.care/skincare/nl/ingredients/serum). This ingredient integrates smoothly into a routine when paired with [panthenol](https://lovi.care/skincare/nl/ingredients/panthenol), [green tea](https://lovi.care/skincare/nl/ingredients/green-tea), and [ceramide-building complex](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex), though it should be kept apart from [adapalene](https://lovi.care/skincare/nl/ingredients/adapalene), [glycolic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid), and [benzoyl peroxide](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide). [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/) This page shows hexapeptide-9 products with a Lovi page. For every product, and a routine built for your skin, use the Lovi app. ### Popular hexapeptide-9 products - [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/nl/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€89.95 at Amazon](https://www.amazon.nl/dp/B00175YVOS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/nl/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit - [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€10.50 at Notino](https://www.notino.nl/mary-may/6-peptide-complex-intensief-herstellende-serum-met-anti-rimpel-werking/p-16211030/) ### Other hexapeptide-9 products - [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/nl/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€89.95 at Amazon](https://www.amazon.nl/dp/B00175YVOS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/nl/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit - [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€10.50 at Notino](https://www.notino.nl/mary-may/6-peptide-complex-intensief-herstellende-serum-met-anti-rimpel-werking/p-16211030/) ## What reviewers say about popular hexapeptide-9 products The highlight reviewers mention most for each popular hexapeptide-9 product on Lovi. - Elemis Pro-Collagen Night Cream Deeply hydrating ★4.7 · 1.6k+ reviews Improves firmness Luxurious texture “The cream really hydrates and my face looks amazing.” [What people say about Pro-Collagen Night Cream](https://lovi.care/skincare/nl/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) - Murad Cellular Hydration Repair Serum Deeply hydrating ★4.8 · 900+ reviews Lightweight texture Unpleasant smell “My skin drinks it up.” [What people say about Cellular Hydration Repair Serum](https://lovi.care/skincare/nl/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) - MARY & MAY 6 Peptide Complex Serum Lightweight & fast-absorbing ★4.6 · 2.4k+ reviews Hydrating & plumping Good value “watery texture sinks right in” [What people say about 6 Peptide Complex Serum](https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) ## What to combine hexapeptide-9 with Ingredient Together How to use them [Panthenol](https://lovi.care/skincare/nl/ingredients/panthenol) Works well Use them together in the same routine, applying [panthenol](https://lovi.care/skincare/nl/ingredients/panthenol) first to calm your skin before the peptide. [Hexapeptide-9 and panthenol](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide-9) [Green tea](https://lovi.care/skincare/nl/ingredients/green-tea) Works well Use them together in the same routine, applying the [green tea](https://lovi.care/skincare/nl/ingredients/green-tea) product first and the hexapeptide-9 product second, because they help each other work better. [Hexapeptide-9 and green tea](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide-9) [Ceramide-building complex](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex) Works well Use them together in the same routine, applying the [ceramide-building complex](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex) first and the hexapeptide-9 right after, because the lipids help the peptide sink in better. [Hexapeptide-9 and ceramide-building complex](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide-9) [Glycerin](https://lovi.care/skincare/nl/ingredients/glycerin) Works well Use them together by applying the [glycerin](https://lovi.care/skincare/nl/ingredients/glycerin) [serum](https://lovi.care/skincare/nl/ingredients/serum) before the [hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide) cream, because hydration helps the peptide sink in better. [Hexapeptide-9 and glycerin](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide-9) [Coenzyme Q10](https://lovi.care/skincare/nl/ingredients/coenzyme-q10) Works well Use them together in the same routine, applying the peptide serum first and following it with the [coenzyme Q10](https://lovi.care/skincare/nl/ingredients/coenzyme-q10) to boost results. [Hexapeptide-9 and coenzyme q10](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide-9) [Vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e) Works well Use them together in the same routine, applying the [vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e) first and the hexapeptide-9 right after, because they help each other work better. [Hexapeptide-9 and vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide-9) [Bakuchiol](https://lovi.care/skincare/nl/ingredients/bakuchiol) Works well Use them together in the same routine, applying the [bakuchiol](https://lovi.care/skincare/nl/ingredients/bakuchiol) first and the hexapeptide-9 right after, because they boost each other's firming power. [Hexapeptide-9 and bakuchiol](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide-9) [Silk amino acids](https://lovi.care/skincare/nl/ingredients/silk-amino-acids) Works well Use them together by applying the [silk amino acids](https://lovi.care/skincare/nl/ingredients/silk-amino-acids) first and the hexapeptide-9 right after, because they help each other boost skin firmness and moisture. [Hexapeptide-9 and silk amino acids](https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-hexapeptide-9) [Arginine](https://lovi.care/skincare/nl/ingredients/arginine) Works well Use them together in the same routine, applying the amino acid first and the peptide right after. [Hexapeptide-9 and arginine](https://lovi.care/skincare/nl/ingredients/arginine-and-hexapeptide-9) [Liposome](https://lovi.care/skincare/nl/ingredients/liposome) Works well Use them together, applying the [liposome](https://lovi.care/skincare/nl/ingredients/liposome) product first and the hexapeptide-9 second, to help the peptide absorb better. [Hexapeptide-9 and liposome](https://lovi.care/skincare/nl/ingredients/liposome-and-hexapeptide-9) [Taurine](https://lovi.care/skincare/nl/ingredients/taurine) Works well Use them together, applying the [taurine](https://lovi.care/skincare/nl/ingredients/taurine) first and then the hexapeptide-9, because they work well to boost skin moisture and firmness. [Hexapeptide-9 and taurine](https://lovi.care/skincare/nl/ingredients/taurine-and-hexapeptide-9) [Hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid) Works well Use them together by applying your hydrating [hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid) serum first, followed by your peptide product, to lock in moisture and help firmness. [Hexapeptide-9 and hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-hexapeptide-9) [Microcapsule](https://lovi.care/skincare/nl/ingredients/microcapsule) Works well Use them together by applying the [microcapsules](https://lovi.care/skincare/nl/ingredients/microcapsule) first, because this delivery system helps the hexapeptide sink in better and work more effectively. [Hexapeptide-9 and microcapsule](https://lovi.care/skincare/nl/ingredients/microcapsule-and-hexapeptide-9) [Cholesterol](https://lovi.care/skincare/nl/ingredients/cholesterol) Works well Use them together in the same routine, applying the [cholesterol](https://lovi.care/skincare/nl/ingredients/cholesterol) cream first and the peptide serum right after. [Hexapeptide-9 and cholesterol](https://lovi.care/skincare/nl/ingredients/cholesterol-and-hexapeptide-9) [Phytosphingosine](https://lovi.care/skincare/nl/ingredients/phytosphingosine) Works well Use them together in the same routine, applying the peptide first and following with the [phytosphingosine](https://lovi.care/skincare/nl/ingredients/phytosphingosine). [Hexapeptide-9 and phytosphingosine](https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-hexapeptide-9) [Betaine](https://lovi.care/skincare/nl/ingredients/betaine) Works well Use them together by applying your [betaine](https://lovi.care/skincare/nl/ingredients/betaine) product first and your hexapeptide-9 product second, because hydration helps the peptide work better. [Hexapeptide-9 and betaine](https://lovi.care/skincare/nl/ingredients/betaine-and-hexapeptide-9) [Phytosterol](https://lovi.care/skincare/nl/ingredients/phytosterol) Works well Use them together by applying the peptide serum first, followed by the [phytosterol](https://lovi.care/skincare/nl/ingredients/phytosterol) cream, because the plant lipids help the firming peptides absorb better. [Hexapeptide-9 and phytosterol](https://lovi.care/skincare/nl/ingredients/phytosterol-and-hexapeptide-9) [Beta-sitosterol](https://lovi.care/skincare/nl/ingredients/beta-sitosterol) Works well Use them together in the same routine, applying the hexapeptide-9 first and the [beta-sitosterol](https://lovi.care/skincare/nl/ingredients/beta-sitosterol) right after, because lipids help peptides absorb better. [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-beta-sitosterol) [Squalene](https://lovi.care/skincare/nl/ingredients/squalene) Works well Use them together in the same routine, applying the [squalene](https://lovi.care/skincare/nl/ingredients/squalene) after the hexapeptide-9, because the oil helps the peptide sink in better. [Hexapeptide-9 and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-squalene) [Tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex) Works well Use them together in the same routine, applying the ceramide [complex](https://lovi.care/skincare/nl/ingredients/complex) first and the peptide serum right after. [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-tri-ceramide-complex) [GABA](https://lovi.care/skincare/nl/ingredients/gaba) Works well Use them together morning and night, because they help each other boost skin firmness and moisture. [Hexapeptide-9 and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-gaba) [Theanine](https://lovi.care/skincare/nl/ingredients/theanine) Works well Use hexapeptide-9 and [theanine](https://lovi.care/skincare/nl/ingredients/theanine) together, applying them both in your morning hydrating routine to support skin firmness and moisture balance. [Hexapeptide-9 and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-theanine) [Vitamin C](https://lovi.care/skincare/nl/ingredients/vitamin-c) Depends Apply your [vitamin C](https://lovi.care/skincare/nl/ingredients/vitamin-c) in the morning and your hexapeptide-9 at night, because mixing them together can make them less effective. [Hexapeptide-9 and vitamin C](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide-9) [Retinol](https://lovi.care/skincare/nl/ingredients/retinol) Depends Use them at different times of day with the peptide serum in the morning and the [retinol](https://lovi.care/skincare/nl/ingredients/retinol) at night, because combining them in the exact same routine can cause irritation. [Hexapeptide-9 and retinol](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide-9) [Niacinamide](https://lovi.care/skincare/nl/ingredients/niacinamide) Depends Use them together in the same routine, applying [niacinamide](https://lovi.care/skincare/nl/ingredients/niacinamide) first and hexapeptide-9 right after, because they boost each other's skin benefits. [Hexapeptide-9 and niacinamide](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide-9) [Adapalene](https://lovi.care/skincare/nl/ingredients/adapalene) Keep apart Use them at different times of day by applying hexapeptide-9 in the morning and [adapalene](https://lovi.care/skincare/nl/ingredients/adapalene) at night, because combining them in the same routine causes skin irritation. [Hexapeptide-9 and adapalene](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide-9) [Glycolic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid) Keep apart Use them at different times of day with the acid first, because the acid breaks down the peptide and stops it from working. [Hexapeptide-9 and glycolic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide-9) [Benzoyl peroxide](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide) Keep apart Use them at different times of day, with [benzoyl peroxide](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide) in the morning and hexapeptide-9 at night, because they cancel each other out. [Hexapeptide-9 and benzoyl peroxide](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide-9) [Azelaic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid) Keep apart Use [azelaic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid) and hexapeptide-9 at different times of day, applying the acid in the morning and the peptide at night, because the acid ruins the peptide. [Hexapeptide-9 and azelaic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide-9) [AHA blend glycolic and citric acids](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids) Keep apart Use them at different times of day, applying the acid first and the peptide later, because the acid is too harsh for the peptide. [Hexapeptide-9 and aha blend glycolic and citric acids](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9) [Salicylic acid](https://lovi.care/skincare/nl/ingredients/salicylic-acid) Keep apart Use them at different times of day, applying [salicylic acid](https://lovi.care/skincare/nl/ingredients/salicylic-acid) first and hexapeptide-9 later, because the acid is too strong for the peptide. [Hexapeptide-9 and salicylic acid](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide-9) [Tretinoin](https://lovi.care/skincare/nl/ingredients/tretinoin) Keep apart Use them at different times of day, applying hexapeptide-9 in the morning and [tretinoin](https://lovi.care/skincare/nl/ingredients/tretinoin) at night, because combining them in the same routine can cause irritation. [Hexapeptide-9 and tretinoin](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide-9) [Vitamin A](https://lovi.care/skincare/nl/ingredients/vitamin-a) Keep apart Use them at different times of day, applying [vitamin A](https://lovi.care/skincare/nl/ingredients/vitamin-a) at night and hexapeptide-9 in the morning, to prevent skin irritation. [Hexapeptide-9 and vitamin A](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-hexapeptide-9) [Pro-retinol](https://lovi.care/skincare/nl/ingredients/pro-retinol) Keep apart Use them at different times of day by applying hexapeptide-9 in the morning and pro-retinol at night to avoid skin irritation. [Hexapeptide-9 and pro-retinol](https://lovi.care/skincare/nl/ingredients/pro-retinol-and-hexapeptide-9) [Retinal](https://lovi.care/skincare/nl/ingredients/retinal) Keep apart Use them at different times of day by applying your hexapeptide-9 in the morning and your [retinal](https://lovi.care/skincare/nl/ingredients/retinal) at night. [Hexapeptide-9 and retinal](https://lovi.care/skincare/nl/ingredients/retinal-and-hexapeptide-9) [Copper](https://lovi.care/skincare/nl/ingredients/copper) Keep apart Use them on alternate nights because they cancel each other out when applied together. [Hexapeptide-9 and copper](https://lovi.care/skincare/nl/ingredients/copper-and-hexapeptide-9) [Magnesium](https://lovi.care/skincare/nl/ingredients/magnesium) Keep apart Use them at different times of day, applying the peptide first and the [magnesium](https://lovi.care/skincare/nl/ingredients/magnesium) later, because mixing them makes the peptide less effective. [Hexapeptide-9 and magnesium](https://lovi.care/skincare/nl/ingredients/magnesium-and-hexapeptide-9) [Lactic acid](https://lovi.care/skincare/nl/ingredients/lactic-acid) Keep apart Use them at different times of day by applying [lactic acid](https://lovi.care/skincare/nl/ingredients/lactic-acid) in the morning and hexapeptide-9 at night, because acid ruins the peptide. [Hexapeptide-9 and lactic acid](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-hexapeptide-9) [Mandelic acid](https://lovi.care/skincare/nl/ingredients/mandelic-acid) Keep apart Apply [mandelic acid](https://lovi.care/skincare/nl/ingredients/mandelic-acid) and hexapeptide-9 at different times of day because the acid destroys the peptide's firmness benefits. [Hexapeptide-9 and mandelic acid](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-hexapeptide-9) [Retinoid blend](https://lovi.care/skincare/nl/ingredients/retinoid-blend) Keep apart Use them at different times of day, applying your retinoid at night and hexapeptide-9 in the morning to prevent extra skin irritation. [Hexapeptide-9 and retinoid blend](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-hexapeptide-9) [Superoxide dismutase](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase) Keep apart Use them at different times of day, applying [superoxide dismutase](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase) first and hexapeptide-9 later, because mixing them breaks down the active ingredients. [Hexapeptide-9 and superoxide dismutase](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-hexapeptide-9) [Polyvinyl alcohol](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol) Keep apart Use them at different times of day, applying hexapeptide-9 first and [polyvinyl alcohol](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol) later, because mixing them makes the peptide treatment less effective. [Hexapeptide-9 and polyvinyl alcohol](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol-and-hexapeptide-9) [Zinc](https://lovi.care/skincare/nl/ingredients/zinc) Keep apart Apply [zinc](https://lovi.care/skincare/nl/ingredients/zinc) in the morning and hexapeptide-9 at night, because mixing them together makes the peptide treatment less effective. [Hexapeptide-9 and zinc](https://lovi.care/skincare/nl/ingredients/zinc-and-hexapeptide-9) [Zinc sulfate](https://lovi.care/skincare/nl/ingredients/zinc-sulfate) Keep apart Use them at different times of day, applying the zinc first, because mixing them together makes the peptide lose its effect. [Hexapeptide-9 and zinc sulfate](https://lovi.care/skincare/nl/ingredients/zinc-sulfate-and-hexapeptide-9) [Bleach](https://lovi.care/skincare/nl/ingredients/bleach) Keep apart Use them at different times of day, applying the peptide first, because mixing them destroys the peptide's anti-aging power. [Hexapeptide-9 and bleach](https://lovi.care/skincare/nl/ingredients/bleach-and-hexapeptide-9) [Granactive retinoid](https://lovi.care/skincare/nl/ingredients/granactive-retinoid) Keep apart Use them at different times of day by applying hexapeptide-9 in the morning and [granactive retinoid](https://lovi.care/skincare/nl/ingredients/granactive-retinoid) at night to prevent irritation. [Hexapeptide-9 and granactive retinoid](https://lovi.care/skincare/nl/ingredients/granactive-retinoid-and-hexapeptide-9) [Hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate) Keep apart Use them at different times of day by applying hexapeptide-9 in the morning and [hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate) at night, to avoid extra skin irritation. [Hexapeptide-9 and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9) [Potassium hydroxide](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide) Keep apart Use them at different times of day with the peptide first, because high alkalinity ruins the peptide. [Hexapeptide-9 and potassium hydroxide](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide-and-hexapeptide-9) [Citric acid](https://lovi.care/skincare/nl/ingredients/citric-acid) Keep apart Use them at different times of day with [citric acid](https://lovi.care/skincare/nl/ingredients/citric-acid) in the morning and hexapeptide-9 at night because acid ruins peptide results. [Hexapeptide-9 and citric acid](https://lovi.care/skincare/nl/ingredients/citric-acid-and-hexapeptide-9) [Isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/isopropyl-alcohol) Keep apart Use them at different times of day, applying the peptide first and the alcohol later, because the alcohol ruins the peptide. [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-isopropyl-alcohol) [Behenyl alcohol](https://lovi.care/skincare/nl/ingredients/behenyl-alcohol) Keep apart Use them at different times of day, applying the peptide first and the alcohol moisturizer later. [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-behenyl-alcohol) [Protease](https://lovi.care/skincare/nl/ingredients/protease) Keep apart Use them at different times of day, applying the hexapeptide-9 first and the [protease](https://lovi.care/skincare/nl/ingredients/protease) later, because they cancel each other out. [Hexapeptide-9 and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-protease) [Baking soda](https://lovi.care/skincare/nl/ingredients/baking-soda) Keep apart Use them at different times of day, applying the peptide first and the [baking soda](https://lovi.care/skincare/nl/ingredients/baking-soda) later, because the baking soda is too harsh for the peptide. [Hexapeptide-9 and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-baking-soda) From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app. ## Questions and answers ### What does hexapeptide-9 do for the skin? Hexapeptide-9 helps reduce wrinkles and skin roughness. Clinical studies show that it can significantly improve aging skin around the crow's feet and forehead. [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/) ### How do you use hexapeptide-9? Hexapeptide-9 helps reduce wrinkles and skin roughness when applied topically. Clinical studies show it outperforms [retinol](https://lovi.care/skincare/nl/ingredients/retinol) in managing signs of skin aging. [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/) ### Should you use hexapeptide-9 in the morning or at night? You can use hexapeptide-9 in the morning or at night, as it depends on the specific ingredients you pair it with. ### Can you use hexapeptide-9 every day? Yes, you can use hexapeptide-9 every day to help reduce wrinkles and skin roughness. Studies show that regular topical use significantly improves the appearance of aging skin over time. [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/) ### Does hexapeptide-9 cause purging or irritation? Hexapeptide-9 is generally considered non-irritating and is unlikely to cause skin purging when used on its own. ### Which skin types is hexapeptide-9 best for? Hexapeptide-9 is best for aging skin, as topical treatment with this ingredient has been shown to significantly reduce wrinkles and roughness in areas like crow's feet and the forehead. [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/) ### Can you use hexapeptide-9 with panthenol? Yes, you can use hexapeptide-9 and [panthenol](https://lovi.care/skincare/nl/ingredients/panthenol) together in the same routine, applying panthenol first to calm your skin before the peptide. ### Can you use hexapeptide-9 with adapalene? No, you cannot use hexapeptide-9 and [adapalene](https://lovi.care/skincare/nl/ingredients/adapalene) together in the same routine because combining them causes skin irritation. Use them at different times of day by applying hexapeptide-9 in the morning and adapalene at night. ## Research on hexapeptide-9 - [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025 ## Combining hexapeptide-9 - Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide-9) - Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/granactive-retinoid-and-hexapeptide-9) - Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9) - Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/pro-retinol-and-hexapeptide-9) - Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinal-and-hexapeptide-9) - Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-hexapeptide-9) - Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide-9) - Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide-9) - Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-hexapeptide-9) - Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/liposome-and-hexapeptide-9) - Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/microcapsule-and-hexapeptide-9) - Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide-9) - Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/betaine-and-hexapeptide-9) - Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide-9) - Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-hexapeptide-9) - Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide-9) - Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide-9) - Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide-9) - Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/arginine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-gaba) - Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-hexapeptide-9) - Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/taurine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9) - Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/citric-acid-and-hexapeptide-9) - Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide-9) - Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-hexapeptide-9) - Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-hexapeptide-9) - Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide-9) - Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide-9) - Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide-9) - Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/cholesterol-and-hexapeptide-9) - Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-hexapeptide-9) - Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosterol-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-squalene) - Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-baking-soda) - Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bleach-and-hexapeptide-9) - Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-behenyl-alcohol) - Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-isopropyl-alcohol) - Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol-and-hexapeptide-9) - Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/copper-and-hexapeptide-9) - Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide-9) - Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/magnesium-and-hexapeptide-9) - Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-and-hexapeptide-9) - Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-sulfate-and-hexapeptide-9) - Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-protease) - Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-hexapeptide-9) ## Brands with hexapeptide-9 - Korean skincare: [MARY & MAY](https://lovi.care/skincare/nl/brands/mary-and-may) - British skincare: [Elemis](https://lovi.care/skincare/nl/brands/elemis) - American skincare: [Murad](https://lovi.care/skincare/nl/brands/murad) ## Related ingredients - [Adapalene](https://lovi.care/skincare/nl/ingredients/adapalene) - [Glycolic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid) - [Benzoyl peroxide](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide) - [Vitamin C](https://lovi.care/skincare/nl/ingredients/vitamin-c) - [Retinol](https://lovi.care/skincare/nl/ingredients/retinol) - [Azelaic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid) - [Panthenol](https://lovi.care/skincare/nl/ingredients/panthenol) - [AHA blend glycolic and citric acids](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids) - [Green tea](https://lovi.care/skincare/nl/ingredients/green-tea) - [Niacinamide](https://lovi.care/skincare/nl/ingredients/niacinamide) - [Salicylic acid](https://lovi.care/skincare/nl/ingredients/salicylic-acid) - [Ceramide-building complex](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex) - [Tretinoin](https://lovi.care/skincare/nl/ingredients/tretinoin) - [Glycerin](https://lovi.care/skincare/nl/ingredients/glycerin) - [Coenzyme Q10](https://lovi.care/skincare/nl/ingredients/coenzyme-q10) - [Vitamin E](https://lovi.care/skincare/nl/ingredients/vitamin-e) - [Bakuchiol](https://lovi.care/skincare/nl/ingredients/bakuchiol) - [Silk amino acids](https://lovi.care/skincare/nl/ingredients/silk-amino-acids) - [Vitamin A](https://lovi.care/skincare/nl/ingredients/vitamin-a) - [Arginine](https://lovi.care/skincare/nl/ingredients/arginine) - [Liposome](https://lovi.care/skincare/nl/ingredients/liposome) - [Pro-retinol](https://lovi.care/skincare/nl/ingredients/pro-retinol) - [Retinal](https://lovi.care/skincare/nl/ingredients/retinal) - [Copper](https://lovi.care/skincare/nl/ingredients/copper) - [Magnesium](https://lovi.care/skincare/nl/ingredients/magnesium) - [Lactic acid](https://lovi.care/skincare/nl/ingredients/lactic-acid) - [Taurine](https://lovi.care/skincare/nl/ingredients/taurine) - [Mandelic acid](https://lovi.care/skincare/nl/ingredients/mandelic-acid) - [Retinoid blend](https://lovi.care/skincare/nl/ingredients/retinoid-blend) - [Superoxide dismutase](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase) - [Hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid) - [Polyvinyl alcohol](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol) - [Zinc](https://lovi.care/skincare/nl/ingredients/zinc) - [Zinc sulfate](https://lovi.care/skincare/nl/ingredients/zinc-sulfate) - [Bleach](https://lovi.care/skincare/nl/ingredients/bleach) - [Granactive retinoid](https://lovi.care/skincare/nl/ingredients/granactive-retinoid) - [Hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate) - [Microcapsule](https://lovi.care/skincare/nl/ingredients/microcapsule) - [Potassium hydroxide](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide) - [Cholesterol](https://lovi.care/skincare/nl/ingredients/cholesterol) - [Phytosphingosine](https://lovi.care/skincare/nl/ingredients/phytosphingosine) - [Betaine](https://lovi.care/skincare/nl/ingredients/betaine) - [Phytosterol](https://lovi.care/skincare/nl/ingredients/phytosterol) - [Citric acid](https://lovi.care/skincare/nl/ingredients/citric-acid) - [Isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/isopropyl-alcohol) - [Beta-sitosterol](https://lovi.care/skincare/nl/ingredients/beta-sitosterol) - [Behenyl alcohol](https://lovi.care/skincare/nl/ingredients/behenyl-alcohol) - [Protease](https://lovi.care/skincare/nl/ingredients/protease) - [Squalene](https://lovi.care/skincare/nl/ingredients/squalene) - [Tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex) - [Baking soda](https://lovi.care/skincare/nl/ingredients/baking-soda) - [GABA](https://lovi.care/skincare/nl/ingredients/gaba) - [Theanine](https://lovi.care/skincare/nl/ingredients/theanine) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every ingredient with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this ingredient guide: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/hexapeptide-9 - United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-9 - Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-9 - Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-9 - France: https://lovi.care/skincare/fr/ingredients/hexapeptide-9 - Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-9 - Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-9 (this page) - Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-9 - Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-9 - Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-9 - Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-9 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-9 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-9