# Hexapeptide-9 and tri-ceramide complex

Page: https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-tri-ceramide-complex

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Work well together

Use them together in the same routine, applying the ceramide [complex](https://lovi.care/skincare/nl/ingredients/complex) first and the peptide [serum](https://lovi.care/skincare/nl/ingredients/serum) right after. Ceramides help lock in moisture while peptides smooth the look of skin. You can use them daily without needing to change anything.

- [All about hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9)
- [All about tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex)

### [Hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/nl/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€89.95 at Amazon](https://www.amazon.nl/dp/B00175YVOS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/nl/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€10.50 at Notino](https://www.notino.nl/mary-may/6-peptide-complex-intensief-herstellende-serum-met-anti-rimpel-werking/p-16211030/)

### [Tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex) products

- [BYOMA Hydrating Serum](https://lovi.care/skincare/nl/p/byoma/hydrating-serum/for/dry-sensitive-skin) — Superior fit — [€96.44 at Amazon](https://www.amazon.nl/dp/B0C7C88ZSK?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [BYOMA Moisturizing Gel-Cream](https://lovi.care/skincare/nl/p/byoma/moisturizing-gel-cream/for/mature-skin) — High fit
- [BYOMA Creamy Jelly Cleanser](https://lovi.care/skincare/nl/p/byoma/creamy-jelly-cleanser/for/dry-skin) — High fit
- [BYOMA Brightening Serum](https://lovi.care/skincare/nl/p/byoma/brightening-serum/for/dry-skin) — High fit
- [BYOMA Balancing Face Mist](https://lovi.care/skincare/nl/p/byoma/balancing-face-mist/for/dry-skin) — Superior fit
- [BYOMA Milky Moisture Cleanser](https://lovi.care/skincare/nl/p/byoma/milky-moisture-cleanser/for/dry-skin) — Superior fit
- [BYOMA Clarifying Serum](https://lovi.care/skincare/nl/p/byoma/clarifying-serum/for/dry-skin) — High fit
- [BYOMA Moisturizing Rich Cream](https://lovi.care/skincare/nl/p/byoma/moisturizing-rich-cream/for/dry-skin) — Superior fit
- [BYOMA De-Puff + Brighten Eye Gel](https://lovi.care/skincare/nl/p/byoma/de-puff-brighten-eye-gel/for/dry-skin) — High fit

## Questions and answers

### Can you use hexapeptide-9 and tri-ceramide complex together?

Yes, [hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) and [tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex) work well together to enhance skin repair and barrier support. Combining these ingredients helps improve absorption and reinforce skin structure, making them a great match for dry, mature, or barrier-impaired skin.

[Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/)

### Which goes first, hexapeptide-9 or tri-ceramide complex?

Hexapeptide-9 and tri-ceramide complex work well together, and since layering order depends on the specific product textures rather than the ingredients themselves, you can apply whichever comes in a lighter formula first. Combining them helps enhance skin barrier repair and absorption. Lovi rates their compatibility as Superior.

### Are hexapeptide-9 and tri-ceramide complex good for sensitive skin?

Hexapeptide-9 and tri-ceramide complex work well together to enhance skin repair and barrier support, making them beneficial for dry, mature, or barrier-impaired skin. Lovi rates this combination as having a High fit for sensitive skin.

## Research on hexapeptide-9 and tri-ceramide complex

- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Work well together: [Benzoyl peroxide and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-tri-ceramide-complex)
- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-hexapeptide-9)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide-9)
- Work well together: [Niacinamide and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/niacinamide-and-tri-ceramide-complex)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Work well together: [Liposome and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/liposome-and-tri-ceramide-complex)
- Work well together: [Tri-ceramide complex and multi-lamellar emulsion](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex-and-multi-lamellar-emulsion)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Betaine and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/betaine-and-tri-ceramide-complex)
- Work well together: [Glycerin and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/glycerin-and-tri-ceramide-complex)
- Work well together: [Hyaluronic acid and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-tri-ceramide-complex)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-tri-ceramide-complex)
- Work well together: [Green tea and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/green-tea-and-tri-ceramide-complex)
- Work well together: [Vitamin E and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-tri-ceramide-complex)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Work well together: [Bio-placenta peptides and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/bio-placenta-peptides-and-tri-ceramide-complex)
- Work well together: [Collagen peptide and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/collagen-peptide-and-tri-ceramide-complex)
- Work well together: [Copper peptide and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/copper-peptide-and-tri-ceramide-complex)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-tri-ceramide-complex)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4)
- Work well together: [Tri-ceramide complex and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex-and-palmitoyl-tripeptide-1)
- Work well together: [Peptide-rich plasma and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/peptide-rich-plasma-and-tri-ceramide-complex)
- Work well together: [Tri-ceramide complex and triple peptide blend](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex-and-triple-peptide-blend)
- Work well together: [Bakuchiol and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [AHA blend glycolic and citric acids and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-tri-ceramide-complex)
- Keep them apart: [Citric acid and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/citric-acid-and-tri-ceramide-complex)
- Keep them apart: [Glycolic acid and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-tri-ceramide-complex)
- Keep them apart: [Lactic acid and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-tri-ceramide-complex)
- Keep them apart: [Mandelic acid and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-tri-ceramide-complex)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Keep them apart: [Bergamot oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/bergamot-oil-and-tri-ceramide-complex)
- Keep them apart: [Camphor oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/camphor-oil-and-tri-ceramide-complex)
- Keep them apart: [Chamomile oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/chamomile-oil-and-tri-ceramide-complex)
- Keep them apart: [Clove leaf oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/clove-leaf-oil-and-tri-ceramide-complex)
- Keep them apart: [Eucalyptus oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/eucalyptus-oil-and-tri-ceramide-complex)
- Keep them apart: [Tri-ceramide complex and geranium oil](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex-and-geranium-oil)
- Keep them apart: [Grapefruit peel oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/grapefruit-peel-oil-and-tri-ceramide-complex)
- Keep them apart: [Lavender oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/lavender-oil-and-tri-ceramide-complex)
- Keep them apart: [Lemon oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/lemon-oil-and-tri-ceramide-complex)
- Keep them apart: [Orange oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/orange-oil-and-tri-ceramide-complex)
- Keep them apart: [Palmarosa oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/palmarosa-oil-and-tri-ceramide-complex)
- Keep them apart: [Peppermint oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/peppermint-oil-and-tri-ceramide-complex)
- Keep them apart: [Rose oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/rose-oil-and-tri-ceramide-complex)
- Keep them apart: [Rosewood oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/rosewood-oil-and-tri-ceramide-complex)
- Keep them apart: [Sandalwood oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/sandalwood-oil-and-tri-ceramide-complex)
- Keep them apart: [Tea tree oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/tea-tree-oil-and-tri-ceramide-complex)
- Keep them apart: [Thyme oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/thyme-oil-and-tri-ceramide-complex)
- Keep them apart: [Wild mint oil and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/wild-mint-oil-and-tri-ceramide-complex)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/copper-and-hexapeptide-9)
- Work well together: [Cholesterol and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/cholesterol-and-tri-ceramide-complex)
- Work well together: [Lauric acid and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/lauric-acid-and-tri-ceramide-complex)
- Work well together: [Linoleic acid and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/linoleic-acid-and-tri-ceramide-complex)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-sulfate-and-hexapeptide-9)
- Work well together: [Allantoin and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/allantoin-and-tri-ceramide-complex)
- Work well together: [Bisabolol and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/bisabolol-and-tri-ceramide-complex)
- Work well together: [Panthenol and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/panthenol-and-tri-ceramide-complex)
- Work well together: [Retinol and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/retinol-and-tri-ceramide-complex)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hexapeptide-9-and-tri-ceramide-complex
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-tri-ceramide-complex
- Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-tri-ceramide-complex
- Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-tri-ceramide-complex
- France: https://lovi.care/skincare/fr/ingredients/hexapeptide-9-and-tri-ceramide-complex
- Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-tri-ceramide-complex
- Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-tri-ceramide-complex (this page)
- Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-9-and-tri-ceramide-complex
- Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-tri-ceramide-complex
- Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-9-and-tri-ceramide-complex
- Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-9-and-tri-ceramide-complex
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-tri-ceramide-complex
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-9-and-tri-ceramide-complex