# Hexapeptide-9 and protease

Page: https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-protease

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Keep them apart

Use them at different times of day, applying the [hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) first and the [protease](https://lovi.care/skincare/nl/ingredients/protease) later, because they cancel each other out. Protease breaks down the firming bonds of hexapeptide-9, making the peptide useless on your skin. You can separate them by using one in the morning and the other at night.

- [All about hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9)
- [All about protease](https://lovi.care/skincare/nl/ingredients/protease)

### [Hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/nl/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€89.95 at Amazon](https://www.amazon.nl/dp/B00175YVOS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/nl/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€10.50 at Notino](https://www.notino.nl/mary-may/6-peptide-complex-intensief-herstellende-serum-met-anti-rimpel-werking/p-16211030/)

### [Protease](https://lovi.care/skincare/nl/ingredients/protease) products

- [COSRX Centella Cleansing Powder](https://lovi.care/skincare/nl/p/cosrx/centella-cleansing-powder/for/combination-skin) — Superior fit
- [FANCL Deep Clear Washing Powder](https://lovi.care/skincare/nl/p/fancl/deep-clear-washing-powder/for/oily-skin) — High fit

## Questions and answers

### Can you use hexapeptide-9 and protease together?

No, you should keep [hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) and [protease](https://lovi.care/skincare/nl/ingredients/protease) apart in your skincare routine because proteases may degrade peptide bonds and render hexapeptide-9 inactive.

### Which goes first, hexapeptide-9 or protease?

You should keep hexapeptide-9 and protease apart because proteases may degrade peptide bonds and render the active inactive. It is best to use them in separate routines.

### Are hexapeptide-9 and protease good for sensitive skin?

Keep hexapeptide-9 and protease apart in your routine because the protease degrades peptide bonds and renders hexapeptide-9 inactive. Lovi rates this combination as having Average compatibility for all skin types.

## Research on hexapeptide-9 and protease

- [Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913](https://pubmed.ncbi.nlm.nih.gov/29146927/) Protease · Scientific Reports, 2017
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-hexapeptide-9)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide-9)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/copper-and-hexapeptide-9)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-sulfate-and-hexapeptide-9)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Bio-placenta peptides and protease](https://lovi.care/skincare/nl/ingredients/bio-placenta-peptides-and-protease)
- Keep them apart: [Collagen peptide and protease](https://lovi.care/skincare/nl/ingredients/collagen-peptide-and-protease)
- Keep them apart: [Copper peptide and protease](https://lovi.care/skincare/nl/ingredients/copper-peptide-and-protease)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-hexapeptide-9)
- Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/protease-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Protease and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/protease-and-palmitoyl-tripeptide-1)
- Keep them apart: [Peptide-rich plasma and protease](https://lovi.care/skincare/nl/ingredients/peptide-rich-plasma-and-protease)
- Keep them apart: [Protease and triple peptide blend](https://lovi.care/skincare/nl/ingredients/protease-and-triple-peptide-blend)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hexapeptide-9-and-protease
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-protease
- Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-protease
- Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-protease
- France: https://lovi.care/skincare/fr/ingredients/hexapeptide-9-and-protease
- Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-protease
- Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-protease (this page)
- Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-9-and-protease
- Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-protease
- Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-9-and-protease
- Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-9-and-protease
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-protease
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-9-and-protease