# Glycolic acid and hydroxypinacolone retinoate Page: https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands. Keep them apart Use them on alternate nights because they are too strong to put on your face at the same time. Using both together can make skin red, dry, and irritated. Try using a gentler strength or waiting longer between applications. [Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects](https://pubmed.ncbi.nlm.nih.gov/28318351/) [Why Topical Retinoids Are Mainstay of Therapy for Acne](https://pubmed.ncbi.nlm.nih.gov/28585191/) - [All about glycolic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid) - [All about hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate) ### [Glycolic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid) products - [The Ordinary Glycolic Acid 7% Toning Solution](https://lovi.care/skincare/nl/p/the-ordinary/glycolic-acid-7-toning-solution/for/combination-skin) — Superior fit — [€12.19 at Amazon](https://www.amazon.nl/dp/B071914GGL?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [RoC Retinol Correxion Deep Wrinkle Night Cream](https://lovi.care/skincare/nl/p/roc/retinol-correxion-deep-wrinkle-night-cream/for/dark-spots) — High fit — [€44.90 at Amazon](https://www.amazon.nl/dp/B0FMK54Q87?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [First Aid Beauty KP Bump Eraser Body Scrub](https://lovi.care/skincare/nl/p/first-aid-beauty/kp-bump-eraser-body-scrub/for/dark-spots) — Average fit — [€26.45 at Amazon](https://www.amazon.nl/dp/B08GNS58PQ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [First Aid Beauty Facial Radiance Pads](https://lovi.care/skincare/nl/p/first-aid-beauty/facial-radiance-pads/for/sensitive-skin) — Superior fit — [€124.67 at Amazon](https://www.amazon.nl/dp/B0G8TPX5DR?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Murad Rapid Dark Spot Correcting Serum](https://lovi.care/skincare/nl/p/murad/rapid-dark-spot-correcting-serum/for/acne-prone-skin) — High fit - [Skinbetter Science AlphaRet Overnight Cream](https://lovi.care/skincare/nl/p/skinbetter-science/alpharet-overnight-cream/for/dry-sensitive-skin) — High fit - [St. Ives Apricot Scrub](https://lovi.care/skincare/nl/p/st-ives/apricot-scrub/for/dry-skin) — Average fit - [COSRX AHA/BHA Clarifying Treatment Toner](https://lovi.care/skincare/nl/p/cosrx/aha-bha-clarifying-treatment-toner/for/oily-acne-prone-skin) — Superior fit — [€20.23 at Lookfantastic](https://www.lookfantastic.nl/p/cosrx-aha-bha-clarifying-treatment-toner-150ml/11401176/) - [Dr. Dennis Gross Alpha Beta Universal Daily Peel](https://lovi.care/skincare/nl/p/dr-dennis-gross/alpha-beta-universal-daily-peel/for/acne-prone-skin) — Superior fit — [€199.00 at Amazon](https://www.amazon.nl/dp/B009QZ595Q?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Pixi Glow Tonic](https://lovi.care/skincare/nl/p/pixi/glow-tonic/for/oily-skin) — Superior fit — [€18.05 at Amazon](https://www.amazon.nl/dp/B09SN5B88W?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Good Molecules Overnight Exfoliating Treatment](https://lovi.care/skincare/nl/p/good-molecules/overnight-exfoliating-treatment/for/oily-skin) — Superior fit — [€22.99 at Amazon](https://www.amazon.nl/dp/B08TMDRF1L?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [CeraVe Skin Renewing Nightly Exfoliating Treatment](https://lovi.care/skincare/nl/p/cerave/skin-renewing-nightly-exfoliating-treatment/for/acne-prone-skin) — High fit ### [Hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate) products - [The Ordinary Granactive Retinoid 2% Emulsion](https://lovi.care/skincare/nl/p/the-ordinary/granactive-retinoid-2-emulsion/for/oily-skin) — High fit — [€12.65 at Lookfantastic](https://www.lookfantastic.nl/p/the-ordinary-granactive-retinoid-2-emulsion-30ml/11363393/) - [IOPE Retinol Super Bounce Serum](https://lovi.care/skincare/nl/p/iope/retinol-super-bounce-serum/for/dark-spots) — Average fit - [BYOMA Sensitive Retinol Oil](https://lovi.care/skincare/nl/p/byoma/sensitive-retinol-oil/for/dry-skin) — Average fit — [€35.00 at Amazon](https://www.amazon.nl/dp/B0CSDWY381?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Medicube Deep Vita A Retinol Serum](https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/acne-prone-skin) — Average fit — [€28.75 at Amazon](https://www.amazon.nl/dp/B0H7JHK95G?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Sunday Riley A+ High-Dose Retinoid Serum](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/oily-acne-prone-skin) — High fit — [€311.09 at Amazon](https://www.amazon.nl/dp/B07T53TFGM?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use glycolic acid and hydroxypinacolone retinoate together? Keep [glycolic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid) and [hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate) apart by using them in separate routine steps, such as applying glycolic acid in the morning or on alternate nights and the retinoid on alternate evenings. Combining both in the same step may cause irritation or barrier disruption because both increase cell turnover. ### Which goes first, glycolic acid or hydroxypinacolone retinoate? Keep glycolic acid and hydroxypinacolone retinoate apart by using them in separate routine steps, such as applying glycolic acid in the morning or on alternate evenings and retinoids on alternate nights. ### Are glycolic acid and hydroxypinacolone retinoate good for sensitive skin? Glycolic acid and hydroxypinacolone retinoate should be kept apart to avoid irritation or barrier disruption. Sensitive, dry, and reactive skin should avoid direct overlap by using them on alternate evenings or at different times of day. ## Research on glycolic acid and hydroxypinacolone retinoate - [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Glycolic acid · Journal of Cosmetic Dermatology, 2019 - [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019 - [Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation](https://pubmed.ncbi.nlm.nih.gov/37510902/) Hydroxypinacolone retinoate · Journal of Clinical Medicine, 2023 - [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023 - [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025 ## Other combinations - Keep them apart: [Glycolic acid and benzoyl peroxide](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-benzoyl-peroxide) - Keep them apart: [Glycolic acid and retinol](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-retinol) - Depends on the strength: [Glycolic acid and niacinamide](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-niacinamide) - Work well together: [Glycolic acid and sodium lactate](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-sodium-lactate) - Work well together: [Glycolic acid and tromethamine](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-tromethamine) - Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate) - Keep them apart: [Bio-placenta peptides and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate) - Keep them apart: [Hydroxypinacolone retinoate and collagen peptide](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-collagen-peptide) - Keep them apart: [Hydroxypinacolone retinoate and copper peptide](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-copper-peptide) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-tripeptide-1) - Keep them apart: [Hydroxypinacolone retinoate and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-peptide-rich-plasma) - Keep them apart: [Hydroxypinacolone retinoate and triple peptide blend](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-triple-peptide-blend) - Depends on the strength: [Niacinamide and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hydroxypinacolone-retinoate) - Work well together: [Glycolic acid and betaine](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-betaine) - Work well together: [Glycolic acid and glycerin](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-glycerin) - Depends on the strength: [Glycolic acid and hyaluronic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hyaluronic-acid) - Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Glycolic acid and bio-placenta peptides](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-bio-placenta-peptides) - Keep them apart: [Glycolic acid and carnosine](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-carnosine) - Keep them apart: [Glycolic acid and collagen peptide](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-collagen-peptide) - Keep them apart: [Glycolic acid and copper peptide](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-copper-peptide) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide-9) - Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Glycolic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Glycolic acid and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-peptide-rich-plasma) - Keep them apart: [Glycolic acid and triple peptide blend](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-triple-peptide-blend) - Keep them apart: [AHA blend glycolic and citric acids and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hydroxypinacolone-retinoate) - Keep them apart: [Hydroxypinacolone retinoate and citric acid](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-citric-acid) - Keep them apart: [Adapalene and glycolic acid](https://lovi.care/skincare/nl/ingredients/adapalene-and-glycolic-acid) - Keep them apart: [Glycolic acid and granactive retinoid](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-granactive-retinoid) - Keep them apart: [Glycolic acid and pro-retinol](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-pro-retinol) - Keep them apart: [Glycolic acid and retinal](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-retinal) - Keep them apart: [Glycolic acid and retinoid blend](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-retinoid-blend) - Keep them apart: [Glycolic acid and tretinoin](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-tretinoin) - Keep them apart: [Lactic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-hydroxypinacolone-retinoate) - Keep them apart: [Mandelic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-hydroxypinacolone-retinoate) - Work well together: [Glycolic acid and gluconolactone](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-gluconolactone) - Work well together: [Glycolic acid and lactobionic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-lactobionic-acid) - Work well together: [Glycolic acid and cholesterol](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-cholesterol) - Work well together: [Glycolic acid and lauric acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-lauric-acid) - Work well together: [Glycolic acid and linoleic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-linoleic-acid) - Keep them apart: [Glycolic acid and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-tri-ceramide-complex) - Work well together: [Glycolic acid and arginine](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-arginine) - Work well together: [Glycolic acid and GABA](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-gaba) - Work well together: [Glycolic acid and silk amino acids](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-silk-amino-acids) - Work well together: [Glycolic acid and taurine](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-taurine) - Work well together: [Glycolic acid and theanine](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-theanine) - Keep them apart: [Salicylic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hydroxypinacolone-retinoate) - Keep them apart: [Vitamin C and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hydroxypinacolone-retinoate) - Work well together: [Glycolic acid and ferulic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-ferulic-acid) - Work well together: [Glycolic acid and vitamin E](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-vitamin-e) - Keep them apart: [Glycolic acid and azelaic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-azelaic-acid) - Keep them apart: [Glycolic acid and salicylic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-salicylic-acid) - Keep them apart: [Benzoyl peroxide and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hydroxypinacolone-retinoate) - Work well together: [Glycolic acid and allantoin](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-allantoin) - Work well together: [Glycolic acid and bisabolol](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-bisabolol) - Work well together: [Glycolic acid and panthenol](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-panthenol) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - United Kingdom: https://lovi.care/skincare/uk/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - Ireland: https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - Germany: https://lovi.care/skincare/de/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - France: https://lovi.care/skincare/fr/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - Italy: https://lovi.care/skincare/it/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - Netherlands: https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate (this page) - Spain: https://lovi.care/skincare/es/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - Canada: https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - Australia: https://lovi.care/skincare/au/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - Singapore: https://lovi.care/skincare/sg/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate