# Copper and hexapeptide-9 Page: https://lovi.care/skincare/nl/ingredients/copper-and-hexapeptide-9 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands. Keep them apart Use them on alternate nights because they cancel each other out when applied together. Combining these two active ingredients can cause them to react and make your routine less effective. You can simply switch to using one in the morning and the other at night, or use them on different days. - [All about copper](https://lovi.care/skincare/nl/ingredients/copper) - [All about hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) ### [Copper](https://lovi.care/skincare/nl/ingredients/copper) products - [Minimalist Vitamin B5 10% Moisturizer](https://lovi.care/skincare/nl/p/minimalist/vitamin-b5-10-moisturizer/for/mature-skin) — High fit ### [Hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) products - [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/nl/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€89.95 at Amazon](https://www.amazon.nl/dp/B00175YVOS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/nl/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit - [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/nl/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€10.50 at Notino](https://www.notino.nl/mary-may/6-peptide-complex-intensief-herstellende-serum-met-anti-rimpel-werking/p-16211030/) ## Questions and answers ### Can you use copper and hexapeptide-9 together? Keep them apart and use them in alternating routines, as [copper](https://lovi.care/skincare/nl/ingredients/copper) and [hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hexapeptide-9) may react or become inactivated when combined. This separation helps protect your skin barrier and maintains the effectiveness of both ingredients. ### Which goes first, copper or hexapeptide-9? Keep copper and hexapeptide-9 apart in your routine because they may react when combined. Use them in alternating routines to prevent oxidation. ### Are copper and hexapeptide-9 good for sensitive skin? Copper and hexapeptide-9 are generally kept apart in the same routine because [copper peptides](https://lovi.care/skincare/nl/ingredients/copper-peptide) may react with strong reducing agents or unstable antioxidants, potentially causing oxidation or inactivation. Lovi rates the fit for sensitive skin as Average when these ingredients are not separated. ## Research on copper and hexapeptide-9 - [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Copper · Journal of Cosmetic Dermatology, 2019 - [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025 ## Other combinations - Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide-9) - Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/granactive-retinoid-and-hexapeptide-9) - Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9) - Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/pro-retinol-and-hexapeptide-9) - Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinal-and-hexapeptide-9) - Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-hexapeptide-9) - Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide-9) - Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide-9) - Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-hexapeptide-9) - Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/liposome-and-hexapeptide-9) - Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/microcapsule-and-hexapeptide-9) - Keep them apart: [Vitamin C and copper](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-copper) - Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide-9) - Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/betaine-and-hexapeptide-9) - Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide-9) - Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-hexapeptide-9) - Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide-9) - Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide-9) - Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide-9) - Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/arginine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-gaba) - Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-hexapeptide-9) - Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/taurine-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9) - Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/citric-acid-and-hexapeptide-9) - Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide-9) - Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-hexapeptide-9) - Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-hexapeptide-9) - Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide-9) - Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide-9) - Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide-9) - Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/cholesterol-and-hexapeptide-9) - Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-hexapeptide-9) - Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/phytosterol-and-hexapeptide-9) - Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-squalene) - Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-baking-soda) - Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/bleach-and-hexapeptide-9) - Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-behenyl-alcohol) - Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-isopropyl-alcohol) - Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol-and-hexapeptide-9) - Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/nl/ingredients/copper-and-acetyl-hexapeptide-3) - Keep them apart: [Bio-placenta peptides and copper](https://lovi.care/skincare/nl/ingredients/bio-placenta-peptides-and-copper) - Keep them apart: [Copper and collagen peptide](https://lovi.care/skincare/nl/ingredients/copper-and-collagen-peptide) - Keep them apart: [Copper and copper peptide](https://lovi.care/skincare/nl/ingredients/copper-and-copper-peptide) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-copper) - Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/copper-and-palmitoyl-pentapeptide-4) - Keep them apart: [Copper and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/copper-and-palmitoyl-tripeptide-1) - Keep them apart: [Copper and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/copper-and-peptide-rich-plasma) - Keep them apart: [Copper and triple peptide blend](https://lovi.care/skincare/nl/ingredients/copper-and-triple-peptide-blend) - Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide-9) - Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/magnesium-and-hexapeptide-9) - Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-and-hexapeptide-9) - Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/zinc-sulfate-and-hexapeptide-9) - Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide-9) - Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-protease) - Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-hexapeptide-9) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/copper-and-hexapeptide-9 - United Kingdom: https://lovi.care/skincare/uk/ingredients/copper-and-hexapeptide-9 - Ireland: https://lovi.care/skincare/ie/ingredients/copper-and-hexapeptide-9 - Germany: https://lovi.care/skincare/de/ingredients/copper-and-hexapeptide-9 - France: https://lovi.care/skincare/fr/ingredients/copper-and-hexapeptide-9 - Italy: https://lovi.care/skincare/it/ingredients/copper-and-hexapeptide-9 - Netherlands: https://lovi.care/skincare/nl/ingredients/copper-and-hexapeptide-9 (this page) - Spain: https://lovi.care/skincare/es/ingredients/copper-and-hexapeptide-9 - Canada: https://lovi.care/skincare/ca/ingredients/copper-and-hexapeptide-9 - Australia: https://lovi.care/skincare/au/ingredients/copper-and-hexapeptide-9 - Singapore: https://lovi.care/skincare/sg/ingredients/copper-and-hexapeptide-9 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/copper-and-hexapeptide-9 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/copper-and-hexapeptide-9