# Azelaic acid and hexapeptide Page: https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands. Keep them apart Use [azelaic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid) and [hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide) at different times of day, applying the acid in the morning and the peptide at night, because mixing them together makes the peptide lose its power. Azelaic acid creates a sour environment on the skin that breaks down the peptide molecules and stops them from working properly. The shopper can change their routine by applying the acid in the morning and the peptide at night, or by using them on alternate days. - [All about azelaic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid) - [All about hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide) ### [Azelaic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid) products - [The Ordinary Azelaic Acid Suspension 10%](https://lovi.care/skincare/nl/p/the-ordinary/azelaic-acid-suspension-10/for/acne-prone-skin) — High fit — [€14.00 at Amazon](https://www.amazon.nl/dp/B0BBLZ2YBP?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Paula's Choice 10% Azelaic Acid Booster](https://lovi.care/skincare/nl/p/paula-s-choice/10-azelaic-acid-booster/for/acne-prone-skin) — High fit — [€49.00 at Amazon](https://www.amazon.nl/dp/B09S9R72XB?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Topicals Faded Serum](https://lovi.care/skincare/nl/p/topicals/faded-serum/for/oily-acne-prone-skin) — Superior fit — [€9.99 at Amazon](https://www.amazon.nl/dp/B0FT32CL2W?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [NATURIUM Azelaic Topical Acid 10%](https://lovi.care/skincare/nl/p/naturium/azelaic-topical-acid-10/for/acne-prone-skin) — Superior fit - [Musely The Spot Cream](https://lovi.care/skincare/nl/p/musely/the-spot-cream/for/mature-skin) — High fit - [Topicals Faded Brightening & Clearing Serum](https://lovi.care/skincare/nl/p/topicals/faded-brightening-and-clearing-serum/for/acne-prone-skin) — High fit - [Bioderma Pigmentbio Sensitive Areas](https://lovi.care/skincare/nl/p/bioderma/pigmentbio-sensitive-areas/for/oily-acne-prone-skin) — High fit — [€39.46 at Amazon](https://www.amazon.nl/dp/B09231D8X3?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) - [Peach Slices Redness Relief Azelaic Acid Serum](https://lovi.care/skincare/nl/p/peach-slices/redness-relief-azelaic-acid-serum/for/sensitive-skin) — High fit - [Finacea Gel](https://lovi.care/skincare/nl/p/finacea/gel/for/oily-acne-prone-skin) — High fit - [NATURIUM Niacinamide Cleansing Gelée 3%](https://lovi.care/skincare/nl/p/naturium/niacinamide-cleansing-gelee-3/for/acne-prone-skin) — High fit - [NATURIUM Azelaic Acid Emulsion 10%](https://lovi.care/skincare/nl/p/naturium/azelaic-acid-emulsion-10/for/acne-prone-skin) — High fit - [StriVectin Daily Reveal Exfoliating Pads](https://lovi.care/skincare/nl/p/strivectin/daily-reveal-exfoliating-pads/for/oily-skin) — Average fit — [€38.78 at Amazon](https://www.amazon.nl/dp/B089TPYFX3?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) ### [Hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide) products - [SkinCeuticals P-TOX](https://lovi.care/skincare/nl/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€155.25 at Lookfantastic](https://www.lookfantastic.nl/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/) ## Questions and answers ### Can you use azelaic acid and hexapeptide together? Keep [azelaic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid) and [hexapeptide](https://lovi.care/skincare/nl/ingredients/hexapeptide) apart because low-pH acids like azelaic acid can reduce peptide activity when used together. Use them in separate steps or routines, such as alternating morning and evening, to get the best results. ### Which goes first, azelaic acid or hexapeptide? Keep azelaic acid and hexapeptide apart by using them in separate steps or routines, such as applying one in the morning and the other at night. Combining them directly in the same routine should be avoided because low-pH acids can reduce peptide activity. ### Are azelaic acid and hexapeptide good for sensitive skin? Keep azelaic acid and hexapeptide apart by using them in separate steps or routines, such as morning and night, because low-pH acids can reduce peptide activity. ## Research on azelaic acid and hexapeptide - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013 - [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023 ## Other combinations - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-pro-retinol) - Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-retinal) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-retinoid-blend) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/nl/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-vitamin-a) - Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-liposome) - Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-microcapsule) - Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-hexapeptide) - Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-betaine) - Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/nl/ingredients/glycerin-and-hexapeptide) - Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/nl/ingredients/niacinamide-and-hexapeptide) - Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/nl/ingredients/panthenol-and-hexapeptide) - Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide) - Keep them apart: [Azelaic acid and hyaluronic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hyaluronic-acid) - Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-arginine) - Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-gaba) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-taurine) - Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide) - Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-citric-acid) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-lactic-acid) - Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-mandelic-acid) - Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-hexapeptide) - Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/nl/ingredients/green-tea-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-hexapeptide) - Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-hexapeptide) - Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-cholesterol) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-phytosterol) - Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-squalene) - Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-baking-soda) - Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-bleach) - Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-potassium-hydroxide) - Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-behenyl-alcohol) - Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-isopropyl-alcohol) - Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-polyvinyl-alcohol) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-copper) - Keep them apart: [Azelaic acid and aha blend glycolic and citric acids](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-aha-blend-glycolic-and-citric-acids) - Keep them apart: [Azelaic acid and citric acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-citric-acid) - Keep them apart: [Glycolic acid and azelaic acid](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-azelaic-acid) - Keep them apart: [Azelaic acid and lactic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-lactic-acid) - Keep them apart: [Azelaic acid and mandelic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-mandelic-acid) - Keep them apart: [Azelaic acid and salicylic acid](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-salicylic-acid) - Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-magnesium) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-zinc) - Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-hexapeptide) - Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Azelaic acid and bio-placenta peptides](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-bio-placenta-peptides) - Keep them apart: [Azelaic acid and collagen peptide](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-collagen-peptide) - Keep them apart: [Azelaic acid and copper peptide](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-copper-peptide) - Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide-9) - Keep them apart: [Azelaic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Azelaic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Azelaic acid and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-peptide-rich-plasma) - Keep them apart: [Azelaic acid and triple peptide blend](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-triple-peptide-blend) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/nl/ingredients/hexapeptide-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/azelaic-acid-and-hexapeptide - United Kingdom: https://lovi.care/skincare/uk/ingredients/azelaic-acid-and-hexapeptide - Ireland: https://lovi.care/skincare/ie/ingredients/azelaic-acid-and-hexapeptide - Germany: https://lovi.care/skincare/de/ingredients/azelaic-acid-and-hexapeptide - France: https://lovi.care/skincare/fr/ingredients/azelaic-acid-and-hexapeptide - Italy: https://lovi.care/skincare/it/ingredients/azelaic-acid-and-hexapeptide - Netherlands: https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-hexapeptide (this page) - Spain: https://lovi.care/skincare/es/ingredients/azelaic-acid-and-hexapeptide - Canada: https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-hexapeptide - Australia: https://lovi.care/skincare/au/ingredients/azelaic-acid-and-hexapeptide - Singapore: https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-hexapeptide - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/azelaic-acid-and-hexapeptide - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/azelaic-acid-and-hexapeptide