# Adapalene and palmitoyl pentapeptide-4

Page: https://lovi.care/skincare/nl/ingredients/adapalene-and-palmitoyl-pentapeptide-4

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Keep them apart

Use them at different times of day, applying the peptide product in the morning and [adapalene](https://lovi.care/skincare/nl/ingredients/adapalene) at night, to avoid extra skin irritation. Using both strong ingredients at the same time can overwhelm your skin and cause redness or irritation. You can safely get the benefits of both by using them on alternate nights or giving your skin more time between them.

- [All about adapalene](https://lovi.care/skincare/nl/ingredients/adapalene)
- [All about palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/palmitoyl-pentapeptide-4)

### [Adapalene](https://lovi.care/skincare/nl/ingredients/adapalene) products

- [Differin Gel](https://lovi.care/skincare/nl/p/differin/gel/for/oily-acne-prone-skin) — High fit
- [Galderma Epiduo Gel](https://lovi.care/skincare/nl/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit
- [La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment](https://lovi.care/skincare/nl/p/la-roche-posay/effaclar-adapalene-gel-0-1-acne-treatment/for/oily-skin) — Superior fit

### [Palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/palmitoyl-pentapeptide-4) products

- [Olay Eye Lifting Serum](https://lovi.care/skincare/nl/p/olay/eye-lifting-serum/for/dry-skin) — High fit

## Questions and answers

### Can you use adapalene and palmitoyl pentapeptide-4 together?

Keep [adapalene](https://lovi.care/skincare/nl/ingredients/adapalene) and [palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/palmitoyl-pentapeptide-4) apart because combining them may increase skin irritation. Instead, alternate their usage by applying adapalene in the evening and peptides in the morning.

### Which goes first, adapalene or palmitoyl pentapeptide-4?

Keep adapalene and palmitoyl pentapeptide-4 apart in your routine because combining them may increase skin irritation. Instead, alternate your usage by applying adapalene in the evening and peptides in the morning.

### Are adapalene and palmitoyl pentapeptide-4 good for sensitive skin?

Keep adapalene and palmitoyl pentapeptide-4 apart in your routine because combined stimulation may increase irritation, especially on sensitive skin. Instead, alternate their usage by applying your retinoid in the evening and peptides in the morning.

## Research on adapalene and palmitoyl pentapeptide-4

- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018
- [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Adapalene · American Journal of Clinical Dermatology, 2022
- [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022
- [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023
- [Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis](https://pubmed.ncbi.nlm.nih.gov/42500768/) Palmitoyl pentapeptide-4 · Cureus, 2026

## Other combinations

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/nl/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Adapalene and bio-placenta peptides](https://lovi.care/skincare/nl/ingredients/adapalene-and-bio-placenta-peptides)
- Keep them apart: [Adapalene and collagen peptide](https://lovi.care/skincare/nl/ingredients/adapalene-and-collagen-peptide)
- Keep them apart: [Adapalene and copper peptide](https://lovi.care/skincare/nl/ingredients/adapalene-and-copper-peptide)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/nl/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/granactive-retinoid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Pro-retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/pro-retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/retinal-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/tretinoin-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Vitamin A and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/nl/ingredients/adapalene-and-palmitoyl-tripeptide-1)
- Keep them apart: [Adapalene and peptide-rich plasma](https://lovi.care/skincare/nl/ingredients/adapalene-and-peptide-rich-plasma)
- Keep them apart: [Adapalene and triple peptide blend](https://lovi.care/skincare/nl/ingredients/adapalene-and-triple-peptide-blend)
- Work well together: [Liposome and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/liposome-and-palmitoyl-pentapeptide-4)
- Work well together: [Microcapsule and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/microcapsule-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Vitamin C and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/vitamin-c-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/nl/ingredients/adapalene-and-niacinamide)
- Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/betaine-and-palmitoyl-pentapeptide-4)
- Work well together: [Glycerin and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/glycerin-and-palmitoyl-pentapeptide-4)
- Work well together: [Hyaluronic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/niacinamide-and-palmitoyl-pentapeptide-4)
- Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/panthenol-and-palmitoyl-pentapeptide-4)
- Work well together: [Bakuchiol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/bakuchiol-and-palmitoyl-pentapeptide-4)
- Work well together: [Arginine and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/arginine-and-palmitoyl-pentapeptide-4)
- Work well together: [GABA and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/gaba-and-palmitoyl-pentapeptide-4)
- Work well together: [Silk amino acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-palmitoyl-pentapeptide-4)
- Work well together: [Taurine and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/taurine-and-palmitoyl-pentapeptide-4)
- Work well together: [Palmitoyl pentapeptide-4 and theanine](https://lovi.care/skincare/nl/ingredients/palmitoyl-pentapeptide-4-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Citric acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/citric-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Work well together: [Coenzyme Q10 and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/coenzyme-q10-and-palmitoyl-pentapeptide-4)
- Work well together: [Green tea and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/green-tea-and-palmitoyl-pentapeptide-4)
- Work well together: [Vitamin E and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Adapalene and aha blend glycolic and citric acids](https://lovi.care/skincare/nl/ingredients/adapalene-and-aha-blend-glycolic-and-citric-acids)
- Keep them apart: [Adapalene and citric acid](https://lovi.care/skincare/nl/ingredients/adapalene-and-citric-acid)
- Keep them apart: [Adapalene and glycolic acid](https://lovi.care/skincare/nl/ingredients/adapalene-and-glycolic-acid)
- Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/nl/ingredients/adapalene-and-lactic-acid)
- Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/nl/ingredients/adapalene-and-mandelic-acid)
- Work well together: [Beta-sitosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/beta-sitosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Ceramide-building complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/ceramide-building-complex-and-palmitoyl-pentapeptide-4)
- Work well together: [Cholesterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/cholesterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/phytosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/squalene-and-palmitoyl-pentapeptide-4)
- Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Salicylic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/salicylic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Adapalene and salicylic acid](https://lovi.care/skincare/nl/ingredients/adapalene-and-salicylic-acid)
- Keep them apart: [Adapalene and vitamin C](https://lovi.care/skincare/nl/ingredients/adapalene-and-vitamin-c)
- Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/baking-soda-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Bleach and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/bleach-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Behenyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/behenyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Isopropyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/isopropyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Polyvinyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/polyvinyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/copper-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Adapalene and benzoyl peroxide](https://lovi.care/skincare/nl/ingredients/adapalene-and-benzoyl-peroxide)
- Keep them apart: [Benzoyl peroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/benzoyl-peroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Magnesium and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/magnesium-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/zinc-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc sulfate and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/zinc-sulfate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Azelaic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/protease-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Superoxide dismutase and palmitoyl pentapeptide-4](https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- United Kingdom: https://lovi.care/skincare/uk/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- Ireland: https://lovi.care/skincare/ie/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- Germany: https://lovi.care/skincare/de/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- France: https://lovi.care/skincare/fr/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- Italy: https://lovi.care/skincare/it/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- Netherlands: https://lovi.care/skincare/nl/ingredients/adapalene-and-palmitoyl-pentapeptide-4 (this page)
- Spain: https://lovi.care/skincare/es/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- Canada: https://lovi.care/skincare/ca/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- Australia: https://lovi.care/skincare/au/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- Singapore: https://lovi.care/skincare/sg/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/adapalene-and-palmitoyl-pentapeptide-4
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/adapalene-and-palmitoyl-pentapeptide-4