# SkinCeuticals vs DOT & KEY

Page: https://lovi.care/skincare/nl/compare/skinceuticals-vs-dot-and-key

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

SkinCeuticals and DOT & KEY are distinct skincare lines serving different complexions and preferences. SkinCeuticals is loved for its targeted [serums](https://lovi.care/skincare/nl/ingredients/serum), nourishing moisturizers, gentle cleansers, and soothing eye products formulated with [glycerin](https://lovi.care/skincare/nl/ingredients/glycerin), [hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid), and [dimethicone](https://lovi.care/skincare/nl/ingredients/dimethicone), which suit dry skin and dry sensitive skin best. Conversely, DOT & KEY is warmly embraced for its sensorially pleasing sunscreens and thoughtfully calibrated formulas that suit balanced, combination, and normal skin best due to their lightweight textures. While both offer supportive daily care, they differ primarily in their formulation weights and ideal skin types.

SkinCeuticals is an American skincare brand founded in 1994 and owned by L'Oréal since 2005.

[loreal.com](https://www.loreal.com/-/media/project/loreal/brand-sites/corp/master/lcorp/press-releases/group/historical-press-releases/loreal-to-acquire-skinceuticals/tt3ntc1214pz-1-702.pdf?rev=d0f68bc6ec2b43c7a701cf396299d650) [skinceuticals-za.com](https://www.skinceuticals-za.com/SkinCeuticals/about-us/t774.aspx) [pitchbook.com](https://pitchbook.com/profiles/company/95212-18)

DOT & KEY is an Indian skincare brand founded in 2018 and owned by FSN E-Commerce Ventures Limited since 2021.

This page compares some of the most popular SkinCeuticals and DOT & KEY products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg5ab3a4dd8d).

### Popular SkinCeuticals vs DOT & KEY products

#### SkinCeuticals

- [P-Tiox](https://lovi.care/skincare/nl/p/skinceuticals/p-tiox/for/dry-skin) — Average fit — [€169.99 at Amazon](https://www.amazon.nl/dp/B0HCM2ZNZJ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [P-TOX](https://lovi.care/skincare/nl/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€155.25 at Lookfantastic](https://www.lookfantastic.nl/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/)
- [Triple Lipid Restore 2:4:2](https://lovi.care/skincare/nl/p/skinceuticals/triple-lipid-restore-2-4-2/for/dry-skin) — Superior fit — [€217.10 at Amazon](https://www.amazon.nl/dp/B07VSC5L1H?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [A.G.E. Advanced Eye](https://lovi.care/skincare/nl/p/skinceuticals/a-g-e-advanced-eye/for/mature-skin) — Superior fit — [€110.00 at Amazon](https://www.amazon.nl/dp/B0DKG2ZBJ9?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [H.A. Intensifier](https://lovi.care/skincare/nl/p/skinceuticals/h-a-intensifier/for/sensitive-skin) — Average fit — [€139.99 at Amazon](https://www.amazon.nl/dp/B01N33L0JS?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Hydrating B5 Gel](https://lovi.care/skincare/nl/p/skinceuticals/hydrating-b5-gel/for/dry-skin) — High fit — [€99.99 at Amazon](https://www.amazon.nl/dp/B0041LS5X8?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Phyto Corrective Gel](https://lovi.care/skincare/nl/p/skinceuticals/phyto-corrective-gel/for/dry-sensitive-skin) — High fit
- [Phloretin CF](https://lovi.care/skincare/nl/p/skinceuticals/phloretin-cf/for/combination-skin) — High fit — [€154.95 at Amazon](https://www.amazon.nl/dp/B0H228X6CQ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)

#### DOT & KEY

- [WATERMELON COOLING SUNSCREEN](https://lovi.care/skincare/nl/p/dot-and-key/watermelon-cooling-sunscreen/for/combination-skin) — Average fit — [€19.18 at Amazon](https://www.amazon.nl/dp/B0BQN2YWN5?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### SkinCeuticals or DOT & KEY: which is better?

SkinCeuticals is generally better suited for most skincare needs, offering an extensive range of products with High and Superior fit levels for dry, sensitive, and oily skin types, whereas DOT & KEY features only a single sunscreen on this page. Ingredients like [hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid) in these formulations help improve skin hydration and support wound healing.

[Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/) [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What is the difference between SkinCeuticals and DOT & KEY?

SkinCeuticals offers a wide range of targeted skincare products that fit dry, dry sensitive, and oily skin best, whereas DOT & KEY features a single sunscreen on this page with average fit levels across all skin types.

### SkinCeuticals or DOT & KEY: which sunscreen is better?

SkinCeuticals offers a sunscreen like Sheer Physical UV Defense SPF 50 that achieves a Superior fit for skin with dark spots, whereas DOT & KEY only provides an Average fit with its Watermelon Cooling Sunscreen.

### Which is more affordable, SkinCeuticals or DOT & KEY?

SkinCeuticals has a high price point while Dot and Key offers a more budget-friendly option.

### Which causes fewer breakouts, SkinCeuticals or DOT & KEY?

SkinCeuticals fits acne-prone skin with High to Superior levels across many of the products on this page, while DOT & KEY features only a single sunscreen with an Average fit. Both brands may help support clearer skin, though SkinCeuticals offers a much wider range designed for breakout-prone users.

### When was SkinCeuticals founded and who owns it compared to DOT & KEY?

SkinCeuticals was founded in 1994 in the United States and has been owned by L'Oréal since 2005. In comparison, DOT & KEY was founded in 2018 in India and has been owned by FSN E-Commerce Ventures Limited since 2021.

### Which SkinCeuticals products are rated as having a Superior fit for dry sensitive skin?

On the Lovi page, SkinCeuticals products rated with a Superior fit for dry sensitive skin include Triple Lipid Restore 2:4:2, Soothing Cleanser Foam, and C E Ferulic.

[American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How many SkinCeuticals products list no fragrance in their ingredients compared to DOT & KEY?

SkinCeuticals has 34 out of 37 products on the page that list no fragrance, while every product from DOT & KEY on this page lists no fragrance.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [Hyaluronic acid and wound healing](https://pubmed.ncbi.nlm.nih.gov/25877441/) Sodium hyaluronate · Journal of Pharmacy & Pharmaceutical Sciences, 2015
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Hyaluronic acid · Drug Delivery, 2017
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Vitamin b5 panthenol, Panthenol · American Journal of Clinical Dermatology, 2002
- [The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review](https://pubmed.ncbi.nlm.nih.gov/30666070/) Aloe barbadensis leaf juice powder, Aloe barbadensis · Iranian Journal of Medical Sciences, 2019
- [Caffeine's mechanisms of action and its cosmetic use](https://pubmed.ncbi.nlm.nih.gov/23075568/) Caffeine · Skin Pharmacology and Physiology, 2013
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation](https://pubmed.ncbi.nlm.nih.gov/18603326/) Ferulic acid · Journal of the American Academy of Dermatology, 2008
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin](https://pubmed.ncbi.nlm.nih.gov/19146606/) Phloretin, Ferulic acid · Journal of Cosmetic Dermatology, 2008
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Effects of menthol and cold on histamine-induced itch and skin reactions in man](https://pubmed.ncbi.nlm.nih.gov/7624016/) Menthol · Neuroscience Letters, 1995
- [Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression](https://pubmed.ncbi.nlm.nih.gov/31861912/) Advanced peptide complex · International Journal of Molecular Sciences, 2019
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract, Chamomilla recutita extract · International Journal of Molecular Medicine, 2016
- [Effect of fermentation time on the content of bioactive compounds with cosmetic and dermatological properties in Kombucha Yerba Mate extracts](https://pubmed.ncbi.nlm.nih.gov/34552134/) Saccharomyces xylinum black tea ferment · Scientific Reports, 2021
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice powder, Aloe barbadensis leaf juice, Aloe barbadensis leaf extract · Clinical Pharmacology, 2018
- [Urea: a comprehensive review of the clinical literature](https://pubmed.ncbi.nlm.nih.gov/24314769/) Urea · Dermatology Online Journal, 2013
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramides · Scientific Reports, 2022
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide eop, Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ferulic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo](https://pubmed.ncbi.nlm.nih.gov/25381913/) Glycyrrhiza glabra extract · Experimental Dermatology, 2015
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Protective effects of a new phloretin derivative against UVB-induced damage in skin cell model and human volunteers](https://pubmed.ncbi.nlm.nih.gov/25334063/) Phloretin · International Journal of Molecular Sciences, 2014
- [Topical taurine bromamine, a new candidate in the treatment of moderate inflammatory acne vulgaris: a pilot study](https://pubmed.ncbi.nlm.nih.gov/18573718/) Taurine · European Journal of Dermatology, 2008
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [Evaluation of Cosmetic and Dermatological Properties of Kombucha-Fermented Berry Leaf Extracts Considered to Be By-Products](https://pubmed.ncbi.nlm.nih.gov/35408743/) Saccharomyces xylinum black tea ferment · Molecules, 2022
- [Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties](https://pubmed.ncbi.nlm.nih.gov/11917251/) Algae extract · Journal of Cosmetic Science, 2002
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Vitamin b5 panthenol, Pantothenic acid, Panthenol · The Journal of Dermatological Treatment, 2017
- [Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R))](https://pubmed.ncbi.nlm.nih.gov/20021046/) Boswellia serrata extract, Boswellia serrata gum · Toxicology Mechanisms and Methods, 2006
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid, Bha beta hydroxy acid · BioMed Research International, 2020
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Glycolic acid · Journal of Cosmetic Dermatology, 2019
- [Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract](https://pubmed.ncbi.nlm.nih.gov/25402429/) Grape seed oil · International Journal of Cosmetic Science, 2015
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Effects of lecithin-based nanoemulsions on skin: Short-time cytotoxicity MTT and BrdU studies, skin penetration of surfactants and additives and the delivery of curcumin](https://pubmed.ncbi.nlm.nih.gov/32165223/) Hydrogenated lecithin · International Journal of Pharmaceutics, 2020
- [Evaluation of anti-acne properties of phloretin in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/26212527/) Phloretin · International Journal of Cosmetic Science, 2016
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel · Phytochemistry, 2001
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019
- [Efficacy of olive leaf extract-containing cream for facial rejuvenation: A pilot study](https://pubmed.ncbi.nlm.nih.gov/32333467/) Olea europaea leaf extract olive leaf extract · Journal of Cosmetic Dermatology, 2020
- [Taurine bromamine (TauBr)--its role in immunity and new perspectives for clinical use](https://pubmed.ncbi.nlm.nih.gov/20804605/) Taurine · Journal of Biomedical Science, 2010
- [Allergy to oxidized limonene and linalool is frequent in the U.K](https://pubmed.ncbi.nlm.nih.gov/24702129/) Citrus aurantium dulcis peel oil · The British Journal of Dermatology, 2014
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid, Bha beta hydroxy acid · Journal of Cosmetic Dermatology, 2024
- [Comparative Study of 35% Glycolic Acid, 20% Salicylic-10% Mandelic Acid, and Phytic Acid Combination Peels in the Treatment of Active Acne and Postacne Pigmentation](https://pubmed.ncbi.nlm.nih.gov/31619887/) Phytic acid · Journal of Cutaneous and Aesthetic Surgery, 2019
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin e · Journal of Cosmetic Dermatology, 2020
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl oligopeptide · Journal of Cosmetic Dermatology, 2015
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Pantothenic acid · Journal of Cosmetic Dermatology, 2019
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid, Bha beta hydroxy acid · Journal of Drugs in Dermatology, 2023
- [Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin](https://pubmed.ncbi.nlm.nih.gov/26805418/) Acetyl dipeptide-1 cetyl ester · Journal of the European Academy of Dermatology and Venereology, 2016
- [Oxidized citrus oil (R-limonene): a frequent skin sensitizer in Europe](https://pubmed.ncbi.nlm.nih.gov/12399762/) Citrus aurantium dulcis peel oil · Journal of the American Academy of Dermatology, 2002
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry](https://pubmed.ncbi.nlm.nih.gov/38831914/) Grapefruit fruit extract · Frontiers in Chemistry, 2024
- [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/33617668/) Capryloyl salicylic acid, Hydroxyethylpiperazine ethane sulfonic acid, Citric acid · Journal of Cosmetic Dermatology, 2021
- [Assessment of Cosmetic and Dermatological Properties and Safety of Use of Model Skin Tonics with Kombucha-Fermented Red Berry Extracts](https://pubmed.ncbi.nlm.nih.gov/36499003/) Saccharomyces xylinum black tea ferment · International Journal of Molecular Sciences, 2022
- [In vivo and in vitro evaluation of octyl methoxycinnamate liposomes](https://pubmed.ncbi.nlm.nih.gov/24376350/) Ethylhexyl methoxycinnamate · International Journal of Nanomedicine, 2013
- [Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial](https://pubmed.ncbi.nlm.nih.gov/40464749/) Ferulic acid · The Journal of Dermatological Treatment, 2025
- [Antiaging, Brightening, and Antioxidant Efficacy of Fermented Bilberry Extract (Vaccinium myrtillus): A Randomized, Double-Blind, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/39064646/) Vaccinium myrtillus fruit extract · Nutrients, 2024
- [Development of grape seed extract based formulations by using non-invasive biophysical technique and its impact on skin aging](https://pubmed.ncbi.nlm.nih.gov/34799340/) Grape seed oil · Pakistan Journal of Pharmaceutical Sciences, 2021
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne](https://pubmed.ncbi.nlm.nih.gov/18853079/) Phenoxyethanol · Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica, 2008
- [Safety assessment of a novel water-soluble extract of Boswellia serrata gum resin: acute toxicity, 90-day sub-chronic toxicity, Ames' bacterial reverse mutation, and in vivo micronucleus assays](https://pubmed.ncbi.nlm.nih.gov/34886755/) Boswellia serrata extract, Boswellia serrata gum · Toxicology Mechanisms and Methods, 2022
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits](https://pubmed.ncbi.nlm.nih.gov/20618556/) Advanced peptide complex · Journal of Cosmetic Dermatology, 2010
- [Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders](https://pubmed.ncbi.nlm.nih.gov/38142012/) Thymus vulgaris extract · International Journal of Pharmaceutics, 2024
- [A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants](https://pubmed.ncbi.nlm.nih.gov/16439809/) Dimethicone · Ostomy/wound Management, 2005
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [A randomized controlled study to evaluate the depigmenting activity of L-ascorbic acid plus phytic acid-serum vs. placebo on solar lentigines](https://pubmed.ncbi.nlm.nih.gov/22151934/) Phytic acid · Journal of Cosmetic Dermatology, 2011
- [Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins](https://pubmed.ncbi.nlm.nih.gov/17035721/) Grape seed oil · Skin Pharmacology and Physiology, 2007
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging](https://pubmed.ncbi.nlm.nih.gov/40635529/) Blueberry extract, Proxylane · Journal of Cosmetic Dermatology, 2025
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Vitamin b5 panthenol, Panthenol · Journal of Cosmetic Dermatology, 2025
- [Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects](https://pubmed.ncbi.nlm.nih.gov/38336313/) Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024
- [Effects of topical boswellic acid on photo and age-damaged skin: clinical, biophysical, and echographic evaluations in a double-blind, randomized, split-face study](https://pubmed.ncbi.nlm.nih.gov/19918712/) Boswellia serrata extract, Boswellia serrata gum · Planta Medica, 2010
- [Enhancing the Cosmetic Potential of Aloe Vera Gel by Kombucha-Mediated Fermentation: Phytochemical Analysis and Evaluation of Antioxidant, Anti-Aging and Moisturizing Properties](https://pubmed.ncbi.nlm.nih.gov/40807366/) Saccharomyces xylinum black tea ferment · Molecules, 2025
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid](https://pubmed.ncbi.nlm.nih.gov/9603669/) Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998
- [Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/23545907/) Capryloyl salicylic acid, Hydroxyethylpiperazine ethane sulfonic acid, Citric acid · Journal of Drugs in Dermatology, 2013
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study](https://pubmed.ncbi.nlm.nih.gov/19146603/) Jojoba esters · Journal of Cosmetic Dermatology, 2008
- [Peptide-pro complex serum: Investigating effects on aged skin](https://pubmed.ncbi.nlm.nih.gov/35426243/) Marine extracts · Journal of Cosmetic Dermatology, 2023
- [Green Synthesis of Copper Oxide Nanoparticles using Cucumis Sativus (Cucumber) Extracts and their Bio-Physical and Biochemical Characterization for Cosmetic and Dermatologic Applications](https://pubmed.ncbi.nlm.nih.gov/32628604/) Cucumis sativus fruit extract · Endocrine, Metabolic & Immune Disorders Drug Targets, 2021
- [Clinical Efficacy of a Flavo-Proxylane Topical Regimen Pre- and Post-ultrasound Procedure for Subjects Undergoing Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist Therapy](https://pubmed.ncbi.nlm.nih.gov/41781778/) Proxylane · Dermatology and Therapy, 2026
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Mitigation of ultraviolet-induced erythema and inflammation by para-hydroxycinnamic acid in human skin](https://pubmed.ncbi.nlm.nih.gov/39138602/) Ethylhexyl methoxycinnamate · International Journal of Cosmetic Science, 2025
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl methoxycinnamate · Archives of Dermatological Research, 2024
- [The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies](https://pubmed.ncbi.nlm.nih.gov/41668671/) Laminaria digitata extract · International Journal of Cosmetic Science, 2026
- [The Application of a Formulation Containing Hydroxypropyl Tetrahydropyrantriol and Niacinamide to Augment Anti-aging Benefits in a Double-blind, Randomized Nonablative Laser Treatment Study](https://pubmed.ncbi.nlm.nih.gov/41647767/) Proxylane · The Journal of Clinical and Aesthetic Dermatology, 2025
- [Clinical Evaluation of a Soap-Free Cleansing Lotion Containing Sodium Cocoyl Apple Amino Acids for Effective Impurity Removal and Skin Barrier Preservation in Healthy Adults With Diverse Skin Types](https://pubmed.ncbi.nlm.nih.gov/40978887/) Cetyl alcohol · Cureus, 2025
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- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025

## The brands

- American skincare: [SkinCeuticals](https://lovi.care/skincare/nl/brands/skinceuticals)
- Indian skincare: [DOT & KEY](https://lovi.care/skincare/nl/brands/dot-and-key)

## More comparisons

- [SKIN1004 vs SkinCeuticals](https://lovi.care/skincare/nl/compare/skin1004-vs-skinceuticals)
- [SKIN1004 vs DOT & KEY](https://lovi.care/skincare/nl/compare/skin1004-vs-dot-and-key)
- [Anua vs SkinCeuticals](https://lovi.care/skincare/nl/compare/anua-vs-skinceuticals)
- [Anua vs DOT & KEY](https://lovi.care/skincare/nl/compare/anua-vs-dot-and-key)
- [Medicube vs SkinCeuticals](https://lovi.care/skincare/nl/compare/medicube-vs-skinceuticals)
- [Medicube vs DOT & KEY](https://lovi.care/skincare/nl/compare/medicube-vs-dot-and-key)
- [The Ordinary vs SkinCeuticals](https://lovi.care/skincare/nl/compare/the-ordinary-vs-skinceuticals)
- [The Ordinary vs DOT & KEY](https://lovi.care/skincare/nl/compare/the-ordinary-vs-dot-and-key)
- [Beauty of Joseon vs SkinCeuticals](https://lovi.care/skincare/nl/compare/beauty-of-joseon-vs-skinceuticals)
- [Beauty of Joseon vs DOT & KEY](https://lovi.care/skincare/nl/compare/beauty-of-joseon-vs-dot-and-key)
- [COSRX vs SkinCeuticals](https://lovi.care/skincare/nl/compare/cosrx-vs-skinceuticals)
- [COSRX vs DOT & KEY](https://lovi.care/skincare/nl/compare/cosrx-vs-dot-and-key)
- [CeraVe vs SkinCeuticals](https://lovi.care/skincare/nl/compare/cerave-vs-skinceuticals)
- [CeraVe vs DOT & KEY](https://lovi.care/skincare/nl/compare/cerave-vs-dot-and-key)
- [La Roche-Posay vs SkinCeuticals](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-skinceuticals)
- [La Roche-Posay vs DOT & KEY](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-dot-and-key)
- [Dr. Althea vs SkinCeuticals](https://lovi.care/skincare/nl/compare/dr-althea-vs-skinceuticals)
- [Dr. Althea vs DOT & KEY](https://lovi.care/skincare/nl/compare/dr-althea-vs-dot-and-key)
- [Some By Mi vs SkinCeuticals](https://lovi.care/skincare/nl/compare/some-by-mi-vs-skinceuticals)
- [Some By Mi vs DOT & KEY](https://lovi.care/skincare/nl/compare/some-by-mi-vs-dot-and-key)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/skinceuticals-vs-dot-and-key
- United Kingdom: https://lovi.care/skincare/uk/compare/skinceuticals-vs-dot-and-key
- Ireland: https://lovi.care/skincare/ie/compare/skinceuticals-vs-dot-and-key
- Germany: https://lovi.care/skincare/de/compare/skinceuticals-vs-dot-and-key
- France: https://lovi.care/skincare/fr/compare/skinceuticals-vs-dot-and-key
- Italy: https://lovi.care/skincare/it/compare/skinceuticals-vs-dot-and-key
- Netherlands: https://lovi.care/skincare/nl/compare/skinceuticals-vs-dot-and-key (this page)
- Spain: https://lovi.care/skincare/es/compare/skinceuticals-vs-dot-and-key
- Canada: https://lovi.care/skincare/ca/compare/skinceuticals-vs-dot-and-key
- Australia: https://lovi.care/skincare/au/compare/skinceuticals-vs-dot-and-key
- Singapore: https://lovi.care/skincare/sg/compare/skinceuticals-vs-dot-and-key
- Saudi Arabia: https://lovi.care/skincare/sa/compare/skinceuticals-vs-dot-and-key
- United Arab Emirates: https://lovi.care/skincare/ae/compare/skinceuticals-vs-dot-and-key