# Sesderma vs FRE Page: https://lovi.care/skincare/nl/compare/sesderma-vs-fre The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands. Sesderma and FRE are distinct skincare brands offering advanced [serums](https://lovi.care/skincare/nl/ingredients/serum) and nourishing formulas. The Spanish enterprise founded in 1989 is known for its meticulously engineered formulas, including the Azelac RU Serum, while the second brand is celebrated for its gentle and effective compositions, such as the [Argan Oil](https://lovi.care/skincare/nl/ingredients/argan-oil). Sesderma suits sensitive, hyperpigmented, and aging skin types best, whereas FRE suits acne-prone skin best. The brands differ through their botanical [extracts](https://lovi.care/skincare/nl/ingredients/extract) and active compounds that refine skin texture versus thoughtful formulations that gently balance and support the complexion. Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) This page compares some of the most popular Sesderma and FRE products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg8d4e72da2e). ### Popular Sesderma vs FRE products #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/nl/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€30.28 at Amazon](https://www.amazon.nl/dp/B00987RKWW?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1) #### FRE - [Argan Oil](https://lovi.care/skincare/nl/p/fre/argan-oil/for/dry-sensitive-skin) — High fit ## Questions and answers ### Sesderma or FRE: which is better? Neither brand is universally better, as Sesderma achieves a High Lovi fit for acne-prone skin and dark spots with its Azelac RU [Serum](https://lovi.care/skincare/nl/ingredients/serum), while FRE reaches a High Lovi fit for dry sensitive skin with its [Argan Oil](https://lovi.care/skincare/nl/ingredients/argan-oil). FRE also has no fragrance in its products on this page, whereas the Sesderma serum contains fragrance. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) [International Journal of Nanomedicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25143733/) ### What is the difference between Sesderma and FRE? Sesderma offers Azelac RU Serum, which has High Lovi fit for acne-prone skin, dark spots, and combination skin, but contains fragrance. FRE offers Argan Oil, which has High Lovi fit for dry sensitive skin and no added fragrance. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) [International Journal of Nanomedicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25143733/) ### Which is more affordable, Sesderma or FRE? Neither Sesderma nor FRE lists pricing details or affordability comparisons for the products on this page. ### Which causes fewer breakouts, Sesderma or FRE? FRE and Sesderma both offer products on this page that may help with breakouts, such as FRE Argan Oil and Sesderma Azelac RU Serum. Lovi rates Azelac RU Serum as having a High fit for acne-prone skin, while Argan Oil receives an Average fit for the same skin type. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) [International Journal of Nanomedicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25143733/) ### Which brand was founded earlier, Sesderma or FRE? Sesderma was founded earlier in 1989 in Spain, whereas FRE was founded in 2016. ### Do both Sesderma and FRE offer products suitable for dry sensitive skin? Yes, FRE offers Argan Oil which has a High Lovi fit for dry sensitive skin, whereas Sesderma's Azelac RU Serum has a Low fit for this skin type. FRE's product also lists no fragrance. [International Journal of Nanomedicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25143733/) ### Which brand includes fragrance in its products listed on this page? Sesderma includes fragrance in its products on this page, specifically in the Azelac RU Serum. In contrast, every FRE product listed on this page is formulated without fragrance. ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration](https://pubmed.ncbi.nlm.nih.gov/25143733/) Argania spinosa kernel oil argan kernel oil · International Journal of Nanomedicine, 2014 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 ## The brands - Spanish skincare: [Sesderma](https://lovi.care/skincare/nl/brands/sesderma) - Skincare: [FRE](https://lovi.care/skincare/nl/brands/fre) ## More comparisons - [SKIN1004 vs Sesderma](https://lovi.care/skincare/nl/compare/skin1004-vs-sesderma) - [SKIN1004 vs FRE](https://lovi.care/skincare/nl/compare/skin1004-vs-fre) - [Anua vs Sesderma](https://lovi.care/skincare/nl/compare/anua-vs-sesderma) - [Anua vs FRE](https://lovi.care/skincare/nl/compare/anua-vs-fre) - [Medicube vs Sesderma](https://lovi.care/skincare/nl/compare/medicube-vs-sesderma) - [Medicube vs FRE](https://lovi.care/skincare/nl/compare/medicube-vs-fre) - [The Ordinary vs Sesderma](https://lovi.care/skincare/nl/compare/the-ordinary-vs-sesderma) - [The Ordinary vs FRE](https://lovi.care/skincare/nl/compare/the-ordinary-vs-fre) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/nl/compare/beauty-of-joseon-vs-sesderma) - [Beauty of Joseon vs FRE](https://lovi.care/skincare/nl/compare/beauty-of-joseon-vs-fre) - [COSRX vs Sesderma](https://lovi.care/skincare/nl/compare/cosrx-vs-sesderma) - [COSRX vs FRE](https://lovi.care/skincare/nl/compare/cosrx-vs-fre) - [CeraVe vs Sesderma](https://lovi.care/skincare/nl/compare/cerave-vs-sesderma) - [CeraVe vs FRE](https://lovi.care/skincare/nl/compare/cerave-vs-fre) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-sesderma) - [La Roche-Posay vs FRE](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-fre) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/nl/compare/dr-althea-vs-sesderma) - [Dr. Althea vs FRE](https://lovi.care/skincare/nl/compare/dr-althea-vs-fre) - [Some By Mi vs Sesderma](https://lovi.care/skincare/nl/compare/some-by-mi-vs-sesderma) - [Some By Mi vs FRE](https://lovi.care/skincare/nl/compare/some-by-mi-vs-fre) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/sesderma-vs-fre - United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-fre - Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-fre - Germany: https://lovi.care/skincare/de/compare/sesderma-vs-fre - France: https://lovi.care/skincare/fr/compare/sesderma-vs-fre - Italy: https://lovi.care/skincare/it/compare/sesderma-vs-fre - Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-fre (this page) - Spain: https://lovi.care/skincare/es/compare/sesderma-vs-fre - Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-fre - Australia: https://lovi.care/skincare/au/compare/sesderma-vs-fre - Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-fre - Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-fre - United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-fre