# No7 vs Sesderma

Page: https://lovi.care/skincare/nl/compare/no7-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

No7 and Sesderma are established skincare brands offering distinct approaches to daily regimens through targeted [serums](https://lovi.care/skincare/nl/ingredients/serum), eye treatments, and moisturizers. The British brand, founded in 1935, utilizes [vitamin C](https://lovi.care/skincare/nl/ingredients/vitamin-c), [shea butter](https://lovi.care/skincare/nl/ingredients/shea-butter), and [hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid) to best support mature and dry skin, while the Spanish brand, founded in 1989, features advanced botanical [extracts](https://lovi.care/skincare/nl/ingredients/extract) and active compounds designed for sensitive, hyperpigmented, and aging skin types. Both labels deliver specialized solutions, with the former featuring standout formulas like the Future Renew Damage Reversal Eye Serum and the latter celebrated for meticulous engineering in products such as the Azelac RU Serum. Ultimately, the two brands differ in their foundational ingredients and regional heritage, allowing users to select formulations tailored to their specific dermatological needs.

No7 is a British skincare brand founded in 1935 and owned by Sycamore Partners since 2025.

[cosmeticsbusiness.com](https://cosmeticsbusiness.com/boots-becomes-standalone-company-after-walgreens-boots-alliance) [en.wikipedia.org](https://en.wikipedia.org/wiki/Walgreens_Boots_Alliance)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular No7 and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgf16bb9c82e).

### Popular No7 vs Sesderma products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/nl/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€30.28 at Amazon](https://www.amazon.nl/dp/B00987RKWW?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)

#### No7

- [Future Renew Damage Reversal Serum](https://lovi.care/skincare/nl/p/no7/future-renew-damage-reversal-serum/for/dry-skin) — High fit — [€25.48 at Amazon](https://www.amazon.nl/dp/B0C2J7Z91J?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Protect & Perfect Intense Advanced Serum](https://lovi.care/skincare/nl/p/no7/protect-and-perfect-intense-advanced-serum/for/dry-skin) — High fit — [€33.76 at Amazon](https://www.amazon.nl/dp/B0719SCY9M?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Restore & Renew Serum](https://lovi.care/skincare/nl/p/no7/restore-and-renew-serum/for/acne-prone-skin) — High fit
- [Pure Retinol Eye Cream](https://lovi.care/skincare/nl/p/no7/pure-retinol-eye-cream/for/mature-skin) — High fit — [€38.00 at Amazon](https://www.amazon.nl/dp/B09GY6GTQC?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Total Renewal Micro-Dermabrasion Exfoliator](https://lovi.care/skincare/nl/p/no7/total-renewal-micro-dermabrasion-exfoliator/for/dry-sensitive-skin) — High fit — [€19.83 at Amazon](https://www.amazon.nl/dp/B00LG07I9E?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Future Renew Damage Reversal Night Cream](https://lovi.care/skincare/nl/p/no7/future-renew-damage-reversal-night-cream/for/mature-skin) — High fit
- [Pure Retinol](https://lovi.care/skincare/nl/p/no7/pure-retinol/for/mature-skin) — Average fit
- [Pure Retinol 1% Night Concentrate](https://lovi.care/skincare/nl/p/no7/pure-retinol-1-night-concentrate/for/combination-skin) — High fit

### No7 vs Sesderma [serums](https://lovi.care/skincare/nl/ingredients/serum) and treatments

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/nl/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€30.28 at Amazon](https://www.amazon.nl/dp/B00987RKWW?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)

#### No7

- [Future Renew Damage Reversal Serum](https://lovi.care/skincare/nl/p/no7/future-renew-damage-reversal-serum/for/dry-skin) — High fit — [€25.48 at Amazon](https://www.amazon.nl/dp/B0C2J7Z91J?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Restore & Renew Serum](https://lovi.care/skincare/nl/p/no7/restore-and-renew-serum/for/acne-prone-skin) — High fit
- [Protect & Perfect Intense Advanced Serum](https://lovi.care/skincare/nl/p/no7/protect-and-perfect-intense-advanced-serum/for/dry-skin) — High fit — [€33.76 at Amazon](https://www.amazon.nl/dp/B0719SCY9M?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Pure Retinol 1% Night Concentrate](https://lovi.care/skincare/nl/p/no7/pure-retinol-1-night-concentrate/for/combination-skin) — High fit
- [Pure Retinol](https://lovi.care/skincare/nl/p/no7/pure-retinol/for/mature-skin) — Average fit

## Questions and answers

### No7 or Sesderma: which is better?

No7 offers a much wider range of products on this page with High Lovi fit levels for mature and dry skin, whereas Sesderma only features a single [serum](https://lovi.care/skincare/nl/ingredients/serum). [Niacinamide](https://lovi.care/skincare/nl/ingredients/niacinamide) in these formulas helps control skin aging and pigmentation.

[Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What is the difference between No7 and Sesderma?

No7 offers a much larger variety of products on this page than Sesderma, covering categories like serums, eye creams, moisturizers, and sunscreens with high Lovi fits for mature, dry, and dark-spotted skin types. Niacinamide helps reduce cutaneous pigmentation and suppresses melanosome transfer, a benefit found in the key ingredients across No7 products.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Which is more affordable, No7 or Sesderma?

This page does not provide pricing information to compare the affordability of No7 and Sesderma.

### Which causes fewer breakouts, No7 or Sesderma?

When comparing the products on this page, both No7 and Sesderma offer items that have a High fit level for acne-prone skin, such as the No7 Restore & Renew Serum and the Sesderma Azelac RU Serum. Reviewers note that No7 helps improve skin feel and texture, but it may also cause skin irritation and adverse reactions.

### Which brand has more products on the comparison page featuring fragrance?

No7 has more products on this page featuring fragrance, with three fragranced items compared to Sesderma which has one. Niacinamide helps reduce cutaneous pigmentation and controls skin aging.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What skin types does the Azelac RU Serum fit best according to its Lovi fit levels?

According to its Lovi fit levels, the Azelac RU Serum fits acne-prone skin, skin with dark spots, and combination skin best with a High rating. For oily skin, oily acne-prone skin, sensitive skin, and mature skin, Lovi rates its fit as Average, while dry sensitive skin and dry skin receive a Low fit.

### When was each brand founded and where are their company origins?

No7 was founded in 1935 in the United Kingdom, whereas Sesderma was founded in 1989 in Spain.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Cosmetic benefits of astaxanthin on humans subjects](https://pubmed.ncbi.nlm.nih.gov/22428137/) Astaxanthin powder · Acta Biochimica Polonica, 2012
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) Ascorbyl glucoside · Journal of Periodontology, 2009
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system](https://pubmed.ncbi.nlm.nih.gov/21411295/) Retinyl palmitate · Colloids and Surfaces. B, Biointerfaces, 2011
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica leaf extract · Molecules, 2023
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2015
- [Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin](https://pubmed.ncbi.nlm.nih.gov/26805418/) Acetyl dipeptide-1 cetyl ester · Journal of the European Academy of Dermatology and Venereology, 2016
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric](https://pubmed.ncbi.nlm.nih.gov/37608511/) Astaxanthin powder · Journal of Cosmetic Dermatology, 2023
- [Comparative physicochemical stability and clinical anti-wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers](https://pubmed.ncbi.nlm.nih.gov/32383548/) Sodium ascorbyl phosphate · Journal of Cosmetic Dermatology, 2021
- [The evaluation of aluminum oxide crystal microdermabrasion for photodamage](https://pubmed.ncbi.nlm.nih.gov/11737128/) Alumina · Dermatologic Surgery, 2001
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) African shea butter · Journal of Cosmetic Dermatology, 2022
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites](https://pubmed.ncbi.nlm.nih.gov/23438139/) Retinyl palmitate · Journal of Cosmetic Dermatology, 2013
- [Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects](https://pubmed.ncbi.nlm.nih.gov/22142309/) Sodium ascorbyl phosphate · Experimental Dermatology, 2012
- [Preparation and characterization of astaxanthin-loaded biodegradable polyhydroxybutyrate (PHB) microbeads for personal care and cosmetic applications](https://pubmed.ncbi.nlm.nih.gov/38072340/) Astaxanthin powder · International Journal of Biological Macromolecules, 2024
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Clinical and histologic changes determine optimal treatment regimens for microdermabrasion](https://pubmed.ncbi.nlm.nih.gov/19753741/) Alumina · The Journal of Dermatological Treatment, 2002
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Octocrylene · Archives of Dermatological Research, 2024
- [Microneedling and Topical Retinyl Palmitate for Acne Scars: A Preliminary Split-Face Study with Placebo Control](https://pubmed.ncbi.nlm.nih.gov/41899112/) Retinyl palmitate · Journal of Clinical Medicine, 2026
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl oligopeptide, Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Shea butter, Butyrospermum parkii butter shea butter, African shea butter · Lasers in Medical Science, 2025
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Octisalate · Journal of Drugs in Dermatology, 2025

## The brands

- British skincare: [No7](https://lovi.care/skincare/nl/brands/no7)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/nl/brands/sesderma)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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