# ISDIN vs Trilogy

Page: https://lovi.care/skincare/nl/compare/isdin-vs-trilogy

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

ISDIN and Trilogy are two established skincare brands recognized for their thoughtfully formulated remedies. The Spanish brand ISDIN, founded in 1975 and owned by Puig, offers elegant moisturizers, advanced sunscreens, restorative [serums](https://lovi.care/skincare/nl/ingredients/serum), and targeted eye products that suit dry skin and sensitive skin best with reliable daily support. Meanwhile, Trilogy is deeply loved for its thoughtful moisturizers and gentle cleansers built on high-performing formulas that suit dry, balanced, and sensitive skin types best. While both provide gentle comfort and dependable protection through carefully crafted solutions, they differ in their specific offerings, with the former featuring standout items like Fusion [Water](https://lovi.care/skincare/nl/ingredients/water), Eryfotona Actinica, and K-Ox Eyes, and the latter featuring the [Vitamin C](https://lovi.care/skincare/nl/ingredients/vitamin-c) Ceramide Night Cream, [Rosehip](https://lovi.care/skincare/nl/ingredients/rosehip-oil) Cream Cleanser, and Line Smoothing Day Cream to address various concerns.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

[puig.com](https://www.puig.com/en/newsroom/new-chapter-for-Isdin-Puig-to-assume-full-ownership/) [beautymatter.com](https://beautymatter.com/articles/puig-to-take-full-ownership-of-isdin-in-1-39-billion-deal) [uploads.puig.com](https://uploads.puig.com/uploads/Puig_NP_Sept_14_EN_fc21e2f47a.pdf)

This page compares some of the most popular ISDIN and Trilogy products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg3f0f88930d).

### Popular ISDIN vs Trilogy products

#### ISDIN

- [Eryfotona Actinica](https://lovi.care/skincare/nl/p/isdin/eryfotona-actinica/for/mature-skin) — Superior fit — [€32.43 at Amazon](https://www.amazon.nl/dp/B0875W6QQG?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Fusion Water](https://lovi.care/skincare/nl/p/isdin/fusion-water/for/dry-sensitive-skin) — Superior fit — [€24.98 at Amazon](https://www.amazon.nl/dp/B09SQF23RV?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [K-Ox Eyes](https://lovi.care/skincare/nl/p/isdin/k-ox-eyes/for/dry-skin) — High fit — [€50.91 at Amazon](https://www.amazon.nl/dp/B01BMLQ4JQ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Hyaluronic Concentrate](https://lovi.care/skincare/nl/p/isdin/hyaluronic-concentrate/for/sensitive-skin) — High fit
- [Hyaluronic Moisture](https://lovi.care/skincare/nl/p/isdin/hyaluronic-moisture/for/dry-sensitive-skin) — Average fit
- [Flavo-C Serum](https://lovi.care/skincare/nl/p/isdin/flavo-c-serum/for/sensitive-skin) — High fit — [€45.97 at Amazon](https://www.amazon.nl/dp/B01BMLQ086?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Uradin Lotion 10](https://lovi.care/skincare/nl/p/isdin/uradin-lotion-10/for/dry-skin) — High fit
- [Retinal Intense Serum](https://lovi.care/skincare/nl/p/isdin/retinal-intense-serum/for/acne-prone-skin) — High fit — [€63.01 at Amazon](https://www.amazon.nl/dp/B0BD9DK6SC?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)

#### Trilogy

- [Rosehip Cream Cleanser](https://lovi.care/skincare/nl/p/trilogy/rosehip-cream-cleanser/for/sensitive-skin) — High fit
- [Line Smoothing Day Cream](https://lovi.care/skincare/nl/p/trilogy/line-smoothing-day-cream/for/dry-skin) — High fit
- [Vitamin C Ceramide Night Cream](https://lovi.care/skincare/nl/p/trilogy/vitamin-c-ceramide-night-cream/for/mature-skin) — High fit

## People Say

ISDIN

Trilogy

- Hydrating formula and deep moisture Sometimes Noted Mostly Mentioned “Keeps skin moisturized — Trilogy Vitamin C Ceramide Night Cream” “Leaves skin thoroughly moisturised — Trilogy Line Smoothing Day Cream” “Feels moisturizing — Trilogy Rosehip Cream Cleanser” “Improved moisture and texture — ISDIN Hyaluronic Moisture”
- Lightweight and non-greasy texture Mostly Mentioned Often Mentioned “absorbs instantly — ISDIN Eryfotona Actinica” “ultra-light fluid product, which makes it super easy to apply — ISDIN Fusion Water” “Lightweight formula absorbs fast — ISDIN Hyaluronic Concentrate” “Not greasy — Trilogy Line Smoothing Day Cream”
- Skin benefits and repair Mostly Mentioned Mostly Mentioned “skin looks smooth and healthy — ISDIN K-Ox Eyes” “helps reduce swelling in the area of my under-eye bags — ISDIN K-Ox Eyes” “Wake to a glowing complexion — Trilogy Vitamin C Ceramide Night Cream” “Noticeable difference — Trilogy Line Smoothing Day Cream”
- Sensitive skin friendly Often Mentioned Sometimes Noted “Sensitive/reactive skin tolerates — ISDIN Hyaluronic Moisture” “no excessive exfoliation — ISDIN Retinal Intense Serum” “doesn't sting eyes — ISDIN Eryfotona Actinica” “Nothing irritated my skin — Trilogy Line Smoothing Day Cream”
- Makeup performance Often Mentioned Not noted “acts like a primer — ISDIN Eryfotona Actinica” “My skin felt sooo hydrated and looks so plump and dewey. — ISDIN Fusion Water” “Great under makeup — ISDIN Hyaluronic Concentrate”
- Fragrance and scent issues Often Mentioned Sometimes Noted “If you are sensitive to fragrances, you might find it irritating — Trilogy Rosehip Cream Cleanser” “Scent is awful — Trilogy Line Smoothing Day Cream” “smell is overpowering — ISDIN Eryfotona Actinica”
- High price point and value Often Mentioned Rarely Noted “Price to be high relative to performance — Trilogy Rosehip Cream Cleanser” “very expensive — ISDIN Eryfotona Actinica”
- Too thick or heavy Not noted Often Mentioned “A little bit too thick — Trilogy Vitamin C Ceramide Night Cream”

## Questions and answers

### ISDIN or Trilogy: which is better?

ISDIN is better for lightweight textures, sensitive skin, and makeup-friendly sunscreens among the products on this page, while Trilogy is better for deep moisture and hydration. Antioxidants help protect against skin damage, and [vitamin C](https://lovi.care/skincare/nl/ingredients/vitamin-c) may improve skin brightness and signs of aging.

[Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/) [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What is the difference between ISDIN and Trilogy?

ISDIN brings a lightweight, non-greasy texture and suits sensitive skin well with its ultralight sunscreens, while Trilogy tends to offer deeper moisture and hydrating formulas but has more fragrance issues. Lovi gives ISDIN fit levels of Superior for dry sensitive skin and acne-prone skin, and Trilogy fit levels of High for sensitive skin.

### ISDIN or Trilogy: which moisturizer is better?

ISDIN is better for lightweight moisture, while Trilogy is better for deep hydration and brightening. For moisturizers on this page, ISDIN has an average fit for dry skin, and Trilogy has a high fit for dry skin.

### Which is more affordable, ISDIN or Trilogy?

Trilogy is often noted by reviewers for a high price point and value, while ISDIN also faces complaints about a high price point.

### Which causes fewer breakouts, ISDIN or Trilogy?

For acne-prone skin, both brands offer products on this page with High Lovi fit levels, such as ISDIN Eryfotona Actinica and Trilogy [Rosehip](https://lovi.care/skincare/nl/ingredients/rosehip-oil) Cream Cleanser. Topical ingredients like vitamin C in products such as Flavo-C [Serum](https://lovi.care/skincare/nl/ingredients/serum) help manage breakouts and skin health.

[Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which brand has more fragrance-free options, ISDIN or Trilogy?

ISDIN has more fragrance-free options than Trilogy, with 3 of its 8 products on this page listing no fragrance compared to 1 of 3 for Trilogy.

### How do the founding years and corporate ownerships of ISDIN and Trilogy compare?

ISDIN was founded earlier in 1975 in Spain and is owned by Puig, whereas Trilogy was founded later in 2002 and has been owned by CITIC Capital Holdings Limited since 2018.

### Which sunscreen brand is better rated for makeup-friendliness, ISDIN or Trilogy?

ISDIN is better rated for makeup-friendliness, as the products on this page are mostly mentioned by reviewers for being makeup-friendly sunscreens. Trilogy does not feature sunscreens on this page.

## Research behind their key ingredients

- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Antioxidants · Drug Delivery, 2017
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial](https://pubmed.ncbi.nlm.nih.gov/29416368/) Melatonin · Clinical, Cosmetic and Investigational Dermatology, 2018
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters](https://pubmed.ncbi.nlm.nih.gov/31437563/) Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters](https://pubmed.ncbi.nlm.nih.gov/40227214/) Octocrylene · Antioxidants, 2025
- [Topical Almond Oil for Prevention of Pressure Injuries: A Single-Blinded Comparison Study](https://pubmed.ncbi.nlm.nih.gov/32379165/) Prunus amygdalus dulcis oil · Journal of Wound, Ostomy, and Continence Nursing, 2020
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl salicylate · Archives of Dermatological Research, 2024
- [The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration](https://pubmed.ncbi.nlm.nih.gov/38140770/) Lens esculenta seed extract · Journal of Cosmetic Dermatology, 2024
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · International Journal of Cosmetic Science, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Shea butter · Lasers in Medical Science, 2025
- [Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin](https://pubmed.ncbi.nlm.nih.gov/41758783/) Ceramide iii · Skin Pharmacology and Physiology, 2026

## The brands

- Spanish skincare: [ISDIN](https://lovi.care/skincare/nl/brands/isdin)
- Skincare: [Trilogy](https://lovi.care/skincare/nl/brands/trilogy)

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- [The Ordinary vs ISDIN](https://lovi.care/skincare/nl/compare/the-ordinary-vs-isdin)
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- [Beauty of Joseon vs ISDIN](https://lovi.care/skincare/nl/compare/beauty-of-joseon-vs-isdin)
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- [CeraVe vs ISDIN](https://lovi.care/skincare/nl/compare/cerave-vs-isdin)
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- [La Roche-Posay vs ISDIN](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-isdin)
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- [Some By Mi vs Trilogy](https://lovi.care/skincare/nl/compare/some-by-mi-vs-trilogy)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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