# ISDIN vs Endocare

Page: https://lovi.care/skincare/nl/compare/isdin-vs-endocare

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

ISDIN and Endocare are Spanish skincare brands established in 1975 and 1996, respectively. The first brand is known for its elegant moisturizers, advanced sunscreens, restorative [serums](https://lovi.care/skincare/nl/ingredients/serum), and targeted eye products featuring thoughtfully balanced formulas, while the second brand is beloved for its nurturing moisturizers and sophisticated formulas. Both suit dry skin best, though the first brand also excels for sensitive skin, the first brand suits mature and acne-prone skin through items like Fusion [Water](https://lovi.care/skincare/nl/ingredients/water), Eryfotona Actinica, and K-Ox Eyes, and the second brand suits mature skin alongside products like the Tensage Cream for acne-prone skin. They differ in their founding years, parent companies, and specific ingredient profiles, with the first brand providing gentle daily comfort and dependable protection and the second brand supporting the skin through advanced scientific formulations.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

[puig.com](https://www.puig.com/en/newsroom/new-chapter-for-Isdin-Puig-to-assume-full-ownership/) [beautymatter.com](https://beautymatter.com/articles/puig-to-take-full-ownership-of-isdin-in-1-39-billion-deal) [uploads.puig.com](https://uploads.puig.com/uploads/Puig_NP_Sept_14_EN_fc21e2f47a.pdf)

Endocare is a Spanish skincare brand founded in 1996 and owned by Cantabria Labs.

[pitchbook.com](https://pitchbook.com/profiles/company/267212-62) [endocare.com.tw](https://www.endocare.com.tw/)

This page compares some of the most popular ISDIN and Endocare products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg7eafde70f5).

### Popular ISDIN vs Endocare products

#### ISDIN

- [Eryfotona Actinica](https://lovi.care/skincare/nl/p/isdin/eryfotona-actinica/for/mature-skin) — Superior fit — [€32.43 at Amazon](https://www.amazon.nl/dp/B0875W6QQG?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Fusion Water](https://lovi.care/skincare/nl/p/isdin/fusion-water/for/dry-sensitive-skin) — Superior fit — [€24.98 at Amazon](https://www.amazon.nl/dp/B09SQF23RV?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [K-Ox Eyes](https://lovi.care/skincare/nl/p/isdin/k-ox-eyes/for/dry-skin) — High fit — [€50.91 at Amazon](https://www.amazon.nl/dp/B01BMLQ4JQ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Hyaluronic Concentrate](https://lovi.care/skincare/nl/p/isdin/hyaluronic-concentrate/for/sensitive-skin) — High fit
- [Hyaluronic Moisture](https://lovi.care/skincare/nl/p/isdin/hyaluronic-moisture/for/dry-sensitive-skin) — Average fit
- [Flavo-C Serum](https://lovi.care/skincare/nl/p/isdin/flavo-c-serum/for/sensitive-skin) — High fit — [€45.97 at Amazon](https://www.amazon.nl/dp/B01BMLQ086?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Uradin Lotion 10](https://lovi.care/skincare/nl/p/isdin/uradin-lotion-10/for/dry-skin) — High fit
- [Retinal Intense Serum](https://lovi.care/skincare/nl/p/isdin/retinal-intense-serum/for/acne-prone-skin) — High fit — [€63.01 at Amazon](https://www.amazon.nl/dp/B0BD9DK6SC?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)

#### Endocare

- [Tensage Cream](https://lovi.care/skincare/nl/p/endocare/tensage-cream/for/mature-skin) — Average fit

## Questions and answers

### ISDIN or Endocare: which is better?

ISDIN is the better choice for most shoppers because the products on this page fit dry skin, sensitive skin, and acne-prone skin best with High to Superior Lovi ratings, whereas Endocare offers only a single moisturizer with Average to Low ratings.

### What is the difference between ISDIN and Endocare?

ISDIN offers a much wider selection of products on this page across multiple categories like sunscreens, [serums](https://lovi.care/skincare/nl/ingredients/serum), and moisturizers, whereas Endocare is represented by only a single moisturizer. Furthermore, ISDIN products achieve High to Superior Lovi fit levels for several skin types, while Endocare Tensage Cream reaches only an Average fit at best.

### ISDIN or Endocare: which moisturizer is better?

For a moisturizer, ISDIN is a better fit overall than Endocare, as the products on this page for ISDIN achieve High fit levels for dry skin, while Endocare's Tensage Cream reaches only Average. Lovi rates ISDIN's Hyaluronic Concentrate at an Average fit for dry skin, whereas Uradin Lotion 10 achieves a High fit.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, ISDIN or Endocare?

Endocare products are not described in terms of pricing on this page, whereas reviewers frequently mention a high price point for the products on this page from ISDIN.

### Which causes fewer breakouts, ISDIN or Endocare?

Both brands offer products with low breakout risks for most users, though ISDIN has specific items rated High for acne-prone skin while Endocare's Tensage Cream is rated Low for acne-prone skin.

### Between ISDIN and Endocare, which brand was founded earlier and in what year?

ISDIN was founded earlier in 1975, whereas Endocare was founded later in 1996.

### How many products from ISDIN contain fragrance compared to Endocare?

On this page, 5 out of 8 ISDIN products list a fragrance, whereas every Endocare product lists no fragrance.

### Which ISDIN sunscreen has a Superior Lovi fit level for mature skin?

Eryfotona Actinica has a Superior Lovi fit level for mature skin.

## Research behind their key ingredients

- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Antioxidants · Drug Delivery, 2017
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate, Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial](https://pubmed.ncbi.nlm.nih.gov/29416368/) Melatonin · Clinical, Cosmetic and Investigational Dermatology, 2018
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [The Effects of Filtrate of the Secretion of the Cryptomphalus Aspersa on Photoaged Skin](https://pubmed.ncbi.nlm.nih.gov/23652894/) Sca · Journal of Drugs in Dermatology, 2013
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [The Moisturizing Efficacy of a Proprietary Dermo-Cosmetic Product( CLS02021) Versus Placebo in a 4-week Application Period](https://pubmed.ncbi.nlm.nih.gov/35774045/) Proprietary · Medical Archives, 2022
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters](https://pubmed.ncbi.nlm.nih.gov/31437563/) Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters](https://pubmed.ncbi.nlm.nih.gov/40227214/) Octocrylene · Antioxidants, 2025
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Efficacy and Safety of a New Cosmeceutical Regimen Based on the Combination of Snail Secretion Filtrate and Snail Egg Extract to Improve Signs of Skin Aging](https://pubmed.ncbi.nlm.nih.gov/32308795/) Sca · The Journal of Clinical and Aesthetic Dermatology, 2020
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl salicylate · Archives of Dermatological Research, 2024
- [The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration](https://pubmed.ncbi.nlm.nih.gov/38140770/) Lens esculenta seed extract · Journal of Cosmetic Dermatology, 2024
- [Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A randomized placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/35763437/) Snail secretion filtrate sca growth factor technology filtrate · Journal of Cosmetic Dermatology, 2022
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · International Journal of Cosmetic Science, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025
- [A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study](https://pubmed.ncbi.nlm.nih.gov/41211697/) Saccharide isomerate · The Journal of Dermatological Treatment, 2025

## The brands

- Spanish skincare: [ISDIN](https://lovi.care/skincare/nl/brands/isdin)
- Spanish skincare: [Endocare](https://lovi.care/skincare/nl/brands/endocare)

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- [Medicube vs Endocare](https://lovi.care/skincare/nl/compare/medicube-vs-endocare)
- [The Ordinary vs ISDIN](https://lovi.care/skincare/nl/compare/the-ordinary-vs-isdin)
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- [Beauty of Joseon vs ISDIN](https://lovi.care/skincare/nl/compare/beauty-of-joseon-vs-isdin)
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- [COSRX vs ISDIN](https://lovi.care/skincare/nl/compare/cosrx-vs-isdin)
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- [CeraVe vs ISDIN](https://lovi.care/skincare/nl/compare/cerave-vs-isdin)
- [CeraVe vs Endocare](https://lovi.care/skincare/nl/compare/cerave-vs-endocare)
- [La Roche-Posay vs ISDIN](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-isdin)
- [La Roche-Posay vs Endocare](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-endocare)
- [Dr. Althea vs ISDIN](https://lovi.care/skincare/nl/compare/dr-althea-vs-isdin)
- [Dr. Althea vs Endocare](https://lovi.care/skincare/nl/compare/dr-althea-vs-endocare)
- [Some By Mi vs ISDIN](https://lovi.care/skincare/nl/compare/some-by-mi-vs-isdin)
- [Some By Mi vs Endocare](https://lovi.care/skincare/nl/compare/some-by-mi-vs-endocare)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/isdin-vs-endocare
- United Kingdom: https://lovi.care/skincare/uk/compare/isdin-vs-endocare
- Ireland: https://lovi.care/skincare/ie/compare/isdin-vs-endocare
- Germany: https://lovi.care/skincare/de/compare/isdin-vs-endocare
- France: https://lovi.care/skincare/fr/compare/isdin-vs-endocare
- Italy: https://lovi.care/skincare/it/compare/isdin-vs-endocare
- Netherlands: https://lovi.care/skincare/nl/compare/isdin-vs-endocare (this page)
- Spain: https://lovi.care/skincare/es/compare/isdin-vs-endocare
- Canada: https://lovi.care/skincare/ca/compare/isdin-vs-endocare
- Australia: https://lovi.care/skincare/au/compare/isdin-vs-endocare
- Singapore: https://lovi.care/skincare/sg/compare/isdin-vs-endocare
- Saudi Arabia: https://lovi.care/skincare/sa/compare/isdin-vs-endocare
- United Arab Emirates: https://lovi.care/skincare/ae/compare/isdin-vs-endocare