# Good Molecules vs Natura Bissé

Page: https://lovi.care/skincare/nl/compare/good-molecules-vs-natura-bisse

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Good Molecules and Natura Bissé are distinct skincare brands founded respectively in America in 2019 and in Spain in 1979. The American brand is widely loved for its thoughtful range of [serums](https://lovi.care/skincare/nl/ingredients/serum), moisturizers, eye products, and exfoliants formulated with [glycerin](https://lovi.care/skincare/nl/ingredients/glycerin) and [hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid), while the Spanish brand is known for its luxurious moisturizers and advanced formulas. Both suit dry skin best, though the former also suits acne-prone skin and the latter suits mature and sensitive skin. They differ primarily in their formulation approaches and core ingredients, as the former delivers proven benefits through barrier-restoring glycerin and hydration-supporting hyaluronic acid, whereas the latter utilizes rich nourishing properties to restore balance and vitality to the complexion.

Good Molecules is an American skincare brand founded in 2019 and owned by Beautylish, Inc..

[beautymatter.com](https://beautymatter.com/articles/aria-growth-partners-makes-investment-in-good-molecules) [goodmolecules.com](https://www.goodmolecules.com/about) [pitchbook.com](https://pitchbook.com/profiles/company/458272-45) [preqin.com](https://www.preqin.com/data/profile/asset/good-molecules--llc-/802471)

Natura Bissé is a Spanish skincare brand founded in 1979 and owned by Natura Bissé International, S.A..

[naturabisse.com](https://www.naturabisse.com/int/en/our-story.html) [tracxn.com](https://tracxn.com/d/accelerator-incubator/ushopal/__yjGH7DKhQGNWnINKarEuFce6tilrPzGJv0PnASFLfpg)

This page compares some of the most popular Good Molecules and Natura Bissé products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgf938579b6d).

### Popular Good Molecules vs Natura Bissé products

#### Natura Bissé

- [Diamond Extreme](https://lovi.care/skincare/nl/p/natura-bisse/diamond-extreme/for/mature-skin) — Superior fit — [€266.80 at Amazon](https://www.amazon.nl/dp/B0BKLRMKZV?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)

#### Good Molecules

- [Discoloration Correcting Serum](https://lovi.care/skincare/nl/p/good-molecules/discoloration-correcting-serum/for/dry-skin) — High fit — [€41.90 at Amazon](https://www.amazon.nl/dp/B0BX32CXP6?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Hyaluronic Acid Serum](https://lovi.care/skincare/nl/p/good-molecules/hyaluronic-acid-serum/for/dry-skin) — Superior fit — [€16.98 at Amazon](https://www.amazon.nl/dp/B08TM8DLFJ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Gentle Retinol Cream](https://lovi.care/skincare/nl/p/good-molecules/gentle-retinol-cream/for/mature-skin) — High fit
- [Niacinamide Serum](https://lovi.care/skincare/nl/p/good-molecules/niacinamide-serum/for/oily-skin) — Average fit — [€17.96 at Amazon](https://www.amazon.nl/dp/B08R994Q1L?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Niacinamide Brightening Toner](https://lovi.care/skincare/nl/p/good-molecules/niacinamide-brightening-toner/for/dry-skin) — High fit — [€55.91 at Amazon](https://www.amazon.nl/dp/B08C2BLPD2?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [PIMPLE PATCHES](https://lovi.care/skincare/nl/p/good-molecules/pimple-patches/for/acne-prone-skin) — Average fit
- [Yerba Mate Wake Up Eye Gel](https://lovi.care/skincare/nl/p/good-molecules/yerba-mate-wake-up-eye-gel/for/mature-skin) — Superior fit — [€13.86 at Amazon](https://www.amazon.nl/dp/B091NJQ29P?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Lightweight Daily Moisturizer](https://lovi.care/skincare/nl/p/good-molecules/lightweight-daily-moisturizer/for/dry-skin) — Superior fit — [€21.59 at Amazon](https://www.amazon.nl/dp/B0C26KZ7G6?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)

### Good Molecules vs Natura Bissé moisturizers

#### Natura Bissé

- [Diamond Extreme](https://lovi.care/skincare/nl/p/natura-bisse/diamond-extreme/for/mature-skin) — Superior fit — [€266.80 at Amazon](https://www.amazon.nl/dp/B0BKLRMKZV?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)

#### Good Molecules

- [Hyaluronic Acid Serum](https://lovi.care/skincare/nl/p/good-molecules/hyaluronic-acid-serum/for/dry-skin) — Superior fit — [€16.98 at Amazon](https://www.amazon.nl/dp/B08TM8DLFJ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Lightweight Daily Moisturizer](https://lovi.care/skincare/nl/p/good-molecules/lightweight-daily-moisturizer/for/dry-skin) — Superior fit — [€21.59 at Amazon](https://www.amazon.nl/dp/B0C26KZ7G6?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Squalane Oil](https://lovi.care/skincare/nl/p/good-molecules/squalane-oil/for/dry-skin) — High fit
- [Ultra-Hydrating Facial Oil](https://lovi.care/skincare/nl/p/good-molecules/ultra-hydrating-facial-oil/for/dry-skin) — High fit
- [Pure Cold-Pressed Rosehip Seed Oil](https://lovi.care/skincare/nl/p/good-molecules/pure-cold-pressed-rosehip-seed-oil/for/dry-sensitive-skin) — High fit

## Questions and answers

### Good Molecules or Natura Bissé: which is better?

Good Molecules offers a wide range of affordable skincare products that fit dry, acne-prone, and sensitive skin well, whereas Natura Bissé features a single luxury moisturizer on this page. Reviewers frequently mention that Good Molecules [serums](https://lovi.care/skincare/nl/ingredients/serum) are affordable and great at fading dark spots, and every product on the Good Molecules page lists no fragrance.

### What is the difference between Good Molecules and Natura Bissé?

Good Molecules offers a wide range of affordable, fragrance-free products that reviewers note help fade dark spots and hydrate, fitting dry, acne-prone, and sensitive skin best. In contrast, Natura Bissé features a luxury product, Diamond Extreme, which contains fragrance and achieves a Superior Lovi fit for mature skin.

### Good Molecules or Natura Bissé: which moisturizer is better?

Good Molecules offers a wider selection of moisturizers that fit dry and sensitive skin at Superior or High levels, such as the Lightweight Daily Moisturizer. Topical [hyaluronic acid](https://lovi.care/skincare/nl/ingredients/hyaluronic-acid) helps improve skin hydration and signs of aging.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, Good Molecules or Natura Bissé?

Good Molecules reviewers frequently mention its products as affordable and offering great value, unlike Natura Bissé which has no such feedback on this page.

### Which causes fewer breakouts, Good Molecules or Natura Bissé?

Good Molecules offers a wide range of products on this page with many options rated High or Average for acne-prone skin, whereas Natura Bissé features only one product on this page, Diamond Extreme, which has an Average fit for acne-prone skin.

### How does the founding year and country of origin compare between Good Molecules and Natura Bissé?

Good Molecules was founded in the United States in 2019, whereas Natura Bissé was founded in Spain earlier, in 1979.

### Which brand has more fragrance-free options, Good Molecules or Natura Bissé?

Good Molecules has more fragrance-free options, as every product on its page lists no fragrance in its ingredients, whereas Natura Bissé includes fragrance in its only product on the page.

### What are the skin types that Good Molecules and Natura Bissé respectively fit best according to their brand-focused routines?

According to their brand-focused routines, Good Molecules fits dry, acne-prone, and sensitive skin best, while Natura Bissé has no skin types listed as its best fit.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate, Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol, Ascorbic acid, Ascorbic acid powder · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction](https://pubmed.ncbi.nlm.nih.gov/27475700/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016
- [Effect of fermentation time on the content of bioactive compounds with cosmetic and dermatological properties in Kombucha Yerba Mate extracts](https://pubmed.ncbi.nlm.nih.gov/34552134/) Ilex paraguariensis leaf extract · Scientific Reports, 2021
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Anti-acne vulgaris effects of chlorogenic acid by anti-inflammatory activity and lipogenesis inhibition](https://pubmed.ncbi.nlm.nih.gov/33433016/) Ilex paraguariensis leaf extract · Experimental Dermatology, 2021
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid, Ascorbic acid powder · Journal of Cosmetic Dermatology, 2020
- [A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations](https://pubmed.ncbi.nlm.nih.gov/26119285/) Arbutin · Journal of Cosmetic Dermatology, 2015
- [Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo](https://pubmed.ncbi.nlm.nih.gov/25381913/) Licorice root extract · Experimental Dermatology, 2015
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine](https://pubmed.ncbi.nlm.nih.gov/17348991/) Acetyl glucosamine · Journal of Cosmetic Dermatology, 2007
- [Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling](https://pubmed.ncbi.nlm.nih.gov/32098197/) Leontopodium alpinum leaf extract flower · Genes, 2020
- [Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells](https://pubmed.ncbi.nlm.nih.gov/23093820/) Leontopodium alpinum leaf extract flower · Mediators of Inflammation, 2012
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days](https://pubmed.ncbi.nlm.nih.gov/30924254/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021
- [Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula](https://pubmed.ncbi.nlm.nih.gov/34198790/) Saccharomyces ferment filtrate · Journal of Clinical Medicine, 2021
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function](https://pubmed.ncbi.nlm.nih.gov/35409270/) Rosamarinus officinalis leaf extract rosemary leaf extract · International Journal of Molecular Sciences, 2022
- [Preparation and evaluation of anti-wrinkle cream containing saffron extract and avocado oil](https://pubmed.ncbi.nlm.nih.gov/31957954/) Avocado oil · Journal of Cosmetic Dermatology, 2020
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018
- [Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques](https://pubmed.ncbi.nlm.nih.gov/28385617/) Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry](https://pubmed.ncbi.nlm.nih.gov/38831914/) Ilex paraguariensis extract · Frontiers in Chemistry, 2024
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study](https://pubmed.ncbi.nlm.nih.gov/33022197/) Arbutin · Journal of Cosmetic Science, 2020
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract, Camellia sinensis leaf water · Clinical, Cosmetic and Investigational Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- ['All-natural' anti-wrinkle emulsion serum with Acmella oleracea extract: A design of experiments (DoE) formulation approach, rheology and in vivo skin performance/efficacy evaluation](https://pubmed.ncbi.nlm.nih.gov/34297422/) Acmella oleracea extract · International Journal of Cosmetic Science, 2021
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Betaine · Molecules, 2024
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [New topical tranexamic acid derivative for the improvement of hyperpigmentation and inflammation in the sun-damaged skin](https://pubmed.ncbi.nlm.nih.gov/32588531/) Cetyl tranexamate mesylate · Journal of Cosmetic Dermatology, 2021
- [Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid](https://pubmed.ncbi.nlm.nih.gov/38794349/) Betaine · Pharmaceutics, 2024
- [Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation](https://pubmed.ncbi.nlm.nih.gov/37183632/) Arbutin · Biomaterials Science, 2023
- [Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres](https://pubmed.ncbi.nlm.nih.gov/25876142/) Papain · Giornale Italiano Di Dermatologia E Venereologia, 2015
- [Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda](https://pubmed.ncbi.nlm.nih.gov/35388606/) Mandelic acid · Journal of Cosmetic Dermatology, 2022
- [The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively](https://pubmed.ncbi.nlm.nih.gov/12535284/) Betaine · Skin Research and Technology, 2003
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer](https://pubmed.ncbi.nlm.nih.gov/35456214/) Saccharomyces ferment filtrate · Journal of Clinical Medicine, 2022
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes](https://pubmed.ncbi.nlm.nih.gov/39778604/) 3-o-ethyl ascorbic acid · Free Radical Biology & Medicine, 2025
- [Formulation and evaluation of exotic fat based cosmeceuticals for skin repair](https://pubmed.ncbi.nlm.nih.gov/20046792/) Mangifera indica seed butter · Indian Journal of Pharmaceutical Sciences, 2008
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Preliminary safety and in vivo efficacy of Acmella oleracea extract-loaded glycolipid emulsion serum-Effects on ocular irritation, dermal absorption, and facial skin biophysical and microrelief properties](https://pubmed.ncbi.nlm.nih.gov/39617635/) Acmella oleracea extract · International Journal of Cosmetic Science, 2025
- [Taurine and Polyphenol Complex Repaired Epidermal Keratinocyte Wounds by Regulating IL8 and TIMP2 Expression](https://pubmed.ncbi.nlm.nih.gov/39194729/) Ilex paraguariensis leaf extract · Current Issues in Molecular Biology, 2024
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging](https://pubmed.ncbi.nlm.nih.gov/38525606/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024
- [Hippophae rhamnoides oil-in-water (O/W) emulsion improves barrier function in healthy human subjects](https://pubmed.ncbi.nlm.nih.gov/25362595/) Hippophae rhamnoides oil · Pakistan Journal of Pharmaceutical Sciences, 2014
- [Development and efficacy assessments of tea seed oil makeup remover](https://pubmed.ncbi.nlm.nih.gov/27988044/) Camellia oleifera seed oil · Annales Pharmaceutiques Francaises, 2017
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Pleiotropic effects of a Camellia sinensis leaf extract on in vitro and in vivo skin health characteristics](https://pubmed.ncbi.nlm.nih.gov/40391588/) Camellia sinensis leaf water · International Journal of Cosmetic Science, 2025
- [Effects of fermented tea seed oil on the skin lipid barrier and microbiome of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41319188/) Camellia oleifera seed oil · International Journal of Cosmetic Science, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025
- [The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color](https://pubmed.ncbi.nlm.nih.gov/33938432/) Saccharomyces ferment filtrate · Skinmed, 2021
- [Efficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/37194909/) Camellia sinensis leaf water · Journal of Cosmetic Dermatology, 2023
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026

## The brands

- American skincare: [Good Molecules](https://lovi.care/skincare/nl/brands/good-molecules)
- Spanish skincare: [Natura Bissé](https://lovi.care/skincare/nl/brands/natura-bisse)

## More comparisons

- [SKIN1004 vs Good Molecules](https://lovi.care/skincare/nl/compare/skin1004-vs-good-molecules)
- [SKIN1004 vs Natura Bissé](https://lovi.care/skincare/nl/compare/skin1004-vs-natura-bisse)
- [Anua vs Good Molecules](https://lovi.care/skincare/nl/compare/anua-vs-good-molecules)
- [Anua vs Natura Bissé](https://lovi.care/skincare/nl/compare/anua-vs-natura-bisse)
- [Medicube vs Good Molecules](https://lovi.care/skincare/nl/compare/medicube-vs-good-molecules)
- [Medicube vs Natura Bissé](https://lovi.care/skincare/nl/compare/medicube-vs-natura-bisse)
- [The Ordinary vs Good Molecules](https://lovi.care/skincare/nl/compare/the-ordinary-vs-good-molecules)
- [The Ordinary vs Natura Bissé](https://lovi.care/skincare/nl/compare/the-ordinary-vs-natura-bisse)
- [Beauty of Joseon vs Good Molecules](https://lovi.care/skincare/nl/compare/beauty-of-joseon-vs-good-molecules)
- [Beauty of Joseon vs Natura Bissé](https://lovi.care/skincare/nl/compare/beauty-of-joseon-vs-natura-bisse)
- [COSRX vs Good Molecules](https://lovi.care/skincare/nl/compare/cosrx-vs-good-molecules)
- [COSRX vs Natura Bissé](https://lovi.care/skincare/nl/compare/cosrx-vs-natura-bisse)
- [CeraVe vs Good Molecules](https://lovi.care/skincare/nl/compare/cerave-vs-good-molecules)
- [CeraVe vs Natura Bissé](https://lovi.care/skincare/nl/compare/cerave-vs-natura-bisse)
- [La Roche-Posay vs Good Molecules](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-good-molecules)
- [La Roche-Posay vs Natura Bissé](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-natura-bisse)
- [Dr. Althea vs Good Molecules](https://lovi.care/skincare/nl/compare/dr-althea-vs-good-molecules)
- [Dr. Althea vs Natura Bissé](https://lovi.care/skincare/nl/compare/dr-althea-vs-natura-bisse)
- [Some By Mi vs Good Molecules](https://lovi.care/skincare/nl/compare/some-by-mi-vs-good-molecules)
- [Some By Mi vs Natura Bissé](https://lovi.care/skincare/nl/compare/some-by-mi-vs-natura-bisse)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/good-molecules-vs-natura-bisse
- United Kingdom: https://lovi.care/skincare/uk/compare/good-molecules-vs-natura-bisse
- Ireland: https://lovi.care/skincare/ie/compare/good-molecules-vs-natura-bisse
- Germany: https://lovi.care/skincare/de/compare/good-molecules-vs-natura-bisse
- France: https://lovi.care/skincare/fr/compare/good-molecules-vs-natura-bisse
- Italy: https://lovi.care/skincare/it/compare/good-molecules-vs-natura-bisse
- Netherlands: https://lovi.care/skincare/nl/compare/good-molecules-vs-natura-bisse (this page)
- Spain: https://lovi.care/skincare/es/compare/good-molecules-vs-natura-bisse
- Canada: https://lovi.care/skincare/ca/compare/good-molecules-vs-natura-bisse
- Australia: https://lovi.care/skincare/au/compare/good-molecules-vs-natura-bisse
- Singapore: https://lovi.care/skincare/sg/compare/good-molecules-vs-natura-bisse
- Saudi Arabia: https://lovi.care/skincare/sa/compare/good-molecules-vs-natura-bisse
- United Arab Emirates: https://lovi.care/skincare/ae/compare/good-molecules-vs-natura-bisse