# FANCL vs Sesderma

Page: https://lovi.care/skincare/nl/compare/fancl-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

FANCL and Sesderma are distinguished skincare brands that offer thoughtful makeup removers, gentle exfoliants, and advanced [serums](https://lovi.care/skincare/nl/ingredients/serum) crafted from pure formulas and active compounds. The Japanese brand suits sensitive, dry, and normal skin types best with its mild care, while the Spanish brand is beloved for addressing sensitive, hyperpigmented, and aging skin with meticulously engineered formulas. Choosing between the two ultimately depends on whether one prefers gentle daily balance or advanced botanical refinement for specific concerns.

FANCL is a Japanese skincare brand founded in 1980 and owned by Kirin Holdings Company, Limited since 2024.

[fancl.jp](https://www.fancl.jp/en/about/outline/index.html) [en.wikipedia.org](https://en.wikipedia.org/wiki/FANCL_Corporation) [pitchbook.com](https://pitchbook.com/profiles/company/40398-22)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular FANCL and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg604f237775).

### Popular FANCL vs Sesderma products

#### FANCL

- [Mild Cleansing Oil](https://lovi.care/skincare/nl/p/fancl/mild-cleansing-oil/for/dry-sensitive-skin) — Superior fit — [€50.00 at Amazon](https://www.amazon.nl/dp/B07F6TYZX7?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- [Facial Washing Powder](https://lovi.care/skincare/nl/p/fancl/facial-washing-powder/for/sensitive-skin) — Superior fit

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/nl/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€30.28 at Amazon](https://www.amazon.nl/dp/B00987RKWW?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### FANCL or Sesderma: which is better?

FANCL products on this page have fragrance-free formulas and generally achieve Superior or High Lovi fit levels across most skin types, making them a better choice for sensitive skin than Sesderma. Sesderma offers targeted options like Azelac RU [Serum](https://lovi.care/skincare/nl/ingredients/serum), but it contains fragrance.

### What is the difference between FANCL and Sesderma?

FANCL stands out because the products on this page list no fragrance, whereas Sesderma includes fragrance in its serum. For fit, Lovi rates FANCL Facial Washing Powder as Superior for sensitive skin.

### Which is more affordable, FANCL or Sesderma?

The page facts do not provide pricing information to compare the affordability of FANCL and Sesderma.

### Which causes fewer breakouts, FANCL or Sesderma?

FANCL is the better choice for acne-prone skin because the products on this page earn a High to Superior fit from Lovi, whereas Sesderma scores Average. Furthermore, every FANCL product on this page lists no fragrance, which helps reduce the likelihood of irritation.

### Which brand uses fragrance in its products, FANCL or Sesderma?

Sesderma uses fragrance in its products on this page, while FANCL lists no fragrance in every product.

### When were the parent companies of FANCL and Sesderma founded?

FANCL has been owned by Kirin Holdings Company, Limited since 2024, while Sesderma is owned by Grupo Sesderma.

### How does the Lovi fit level for dry skin compare between FANCL Mild Cleansing Oil and Sesderma Azelac RU Serum?

FANCL Mild Cleansing Oil has a Superior Lovi fit level for dry skin, whereas Sesderma Azelac RU Serum has a Low fit level.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Japanese skincare: [FANCL](https://lovi.care/skincare/nl/brands/fancl)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/nl/brands/sesderma)

## More comparisons

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- [SKIN1004 vs Sesderma](https://lovi.care/skincare/nl/compare/skin1004-vs-sesderma)
- [Anua vs FANCL](https://lovi.care/skincare/nl/compare/anua-vs-fancl)
- [Anua vs Sesderma](https://lovi.care/skincare/nl/compare/anua-vs-sesderma)
- [Medicube vs FANCL](https://lovi.care/skincare/nl/compare/medicube-vs-fancl)
- [Medicube vs Sesderma](https://lovi.care/skincare/nl/compare/medicube-vs-sesderma)
- [The Ordinary vs FANCL](https://lovi.care/skincare/nl/compare/the-ordinary-vs-fancl)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/nl/compare/the-ordinary-vs-sesderma)
- [Beauty of Joseon vs FANCL](https://lovi.care/skincare/nl/compare/beauty-of-joseon-vs-fancl)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/nl/compare/beauty-of-joseon-vs-sesderma)
- [COSRX vs FANCL](https://lovi.care/skincare/nl/compare/cosrx-vs-fancl)
- [COSRX vs Sesderma](https://lovi.care/skincare/nl/compare/cosrx-vs-sesderma)
- [CeraVe vs FANCL](https://lovi.care/skincare/nl/compare/cerave-vs-fancl)
- [CeraVe vs Sesderma](https://lovi.care/skincare/nl/compare/cerave-vs-sesderma)
- [La Roche-Posay vs FANCL](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-fancl)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/nl/compare/la-roche-posay-vs-sesderma)
- [Dr. Althea vs FANCL](https://lovi.care/skincare/nl/compare/dr-althea-vs-fancl)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/nl/compare/dr-althea-vs-sesderma)
- [Some By Mi vs FANCL](https://lovi.care/skincare/nl/compare/some-by-mi-vs-fancl)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/nl/compare/some-by-mi-vs-sesderma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/fancl-vs-sesderma
- United Kingdom: https://lovi.care/skincare/uk/compare/fancl-vs-sesderma
- Ireland: https://lovi.care/skincare/ie/compare/fancl-vs-sesderma
- Germany: https://lovi.care/skincare/de/compare/fancl-vs-sesderma
- France: https://lovi.care/skincare/fr/compare/fancl-vs-sesderma
- Italy: https://lovi.care/skincare/it/compare/fancl-vs-sesderma
- Netherlands: https://lovi.care/skincare/nl/compare/fancl-vs-sesderma (this page)
- Spain: https://lovi.care/skincare/es/compare/fancl-vs-sesderma
- Canada: https://lovi.care/skincare/ca/compare/fancl-vs-sesderma
- Australia: https://lovi.care/skincare/au/compare/fancl-vs-sesderma
- Singapore: https://lovi.care/skincare/sg/compare/fancl-vs-sesderma
- Saudi Arabia: https://lovi.care/skincare/sa/compare/fancl-vs-sesderma
- United Arab Emirates: https://lovi.care/skincare/ae/compare/fancl-vs-sesderma