ZO Skin Health Instant Pore Refiner for combination skin

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Questions and answers

What the research says

• Retinyl palmitate ethosomal hydrogel reduced non-inflammatory and total acne lesion counts significantly better than marketed tretinoin while improving tolerability with minimal skin irritation in patients with acne vulgaris.

  International Journal of Nanomedicine, 2021

• A vitamin A palmitate and antioxidant-containing oil-based moisturizer improved fine lines, wrinkles, pigmentation, tone, texture, dryness, firmness, and clarity across various body sites compared to a no-treatment group over 12 weeks.

  Journal of Cosmetic Dermatology, 2013

• Topical application of a cream containing the NHE1 activator rosmarinic acid decreased skin surface pH and transepidermal water loss while increasing skin hydration in 50-60-year-old adult females compared to vehicle cream and no treatment.

  International Journal of Molecular Sciences, 2022

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

• Topical treatments containing rosehip extract may reduce the size and erythema of postsurgical scars through macrophage polarization and inflammatory cytokine inhibition, though current clinical evidence remains insufficient to recommend its routine use.

  Journal of Cosmetic Dermatology, 2024

• Sunflower and rosehip oil nanoemulsions prepared with a mix of phospholipids and synthetic emulsifiers permeated intact skin to the dermis and showed a more prominent healing effect in a human organotypic skin explant culture wound model compared to nanoemulsions prepared only with phospholipids.

  Pharmaceutics, 2023

• Topical treatment with rosehip seed oil stimulates hair growth in telogenic C57BL/6 mice by inducing the early transition of hair follicles from the telogen to the anagen phase and upregulating hair growth-associated genes.

  Preventive Nutrition and Food Science, 2023

Why other serums fit combination skin better

• Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.

  BioMed Research International, 2022

• A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.

  Journal of Cosmetic Dermatology, 2024

Ingredients

Water, Coconut Alkanes, Methylheptyl Isostearate, Cetyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Isohexadecane, Butylene Glycol, Carthamus Tinctorius Seed Oil, Squalane, Jojoba Seed Oil, Aleurites Moluccana Seed Oil, Plukenetia Volubilis Seed Oil, Helianthus Annuus Seed Oil, Rosa Canina Fruit Extract, Rosmarinus Officinalis Leaf Extract, Leontopodium Alpinum Meristem Cell Culture, Marrubium Vulgare Meristem Cell Culture, Polymethyl Methacrylate, Glycerin, Coco-Caprylate Caprate, Glycol Distearate, Polyacrylamide, Oleth-20, C13-14 Isoparaffin, Caprylyl Glycol, Salicyloyl Phytosphingosine, Ethylene Glycol Monostearate, Xanthan Gum, Tocopheryl Acetate, Propanediol, Caesalpinia Spinosa Gum, Laureth-7, Disodium Edta, Ethyl Ferulate, Myristyl Alcohol, Stearyl Alcohol, Aminomethyl Propanol, Sodium Hyaluronate, Isostearic Acid, Retinyl Palmitate, Ascorbic Acid, Methylene Glycol, Fatty Acid C14-18, Lauryl Alcohol, Lecithin, Tocopherol, Phenoxyethanol, Chlorphenesin, Glyceryl Caprylate, Glyceryl Undecylenate, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.