# ZO Skin Health Growth Factor Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [ZO Skin Health](https://lovi.care/skincare/it/brands/zo-skin-health)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, the Buddleja Davidii Meristem Cell Culture and Dipeptide Diaminobutyroyl Benzylamide Diacetate work to reduce inflammation and regulate sebum, supporting skin regeneration and fine line reduction.
- While Glycerin provides general hydration, the formulation's primary benefits are not directly targeted at managing oily shine, which is your main concern.
- The product is safe for your combination skin, as it contains no harsh or prohibited ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Dipeptide Diaminobutyroyl Benzylamide Diacetate, Adenosine Triphosphate, Beta-Glucan, Angelica Polymorpha Sinensis Root Extract, Hydrolyzed Sericin

## What the research says

- A novel anti-aging serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide, and laminaria extract significantly increased anti-aging biomarkers and improved static and dynamic wrinkles as well as skin quality in clinical studies. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/))
- Verbascoside- and teupolioside-containing extracts significantly accelerated wound healing, exhibited anti-inflammatory action, inhibited reactive oxygen species release, and suppressed chemokine and growth factor expression in cultured human keratinocytes compared to pro-inflammatory controls. ([Cellular and Molecular Biology, 2007](https://pubmed.ncbi.nlm.nih.gov/17543237/))
- Knockout of the TRPV3 gene and topical applications of selective TRPV3 inhibitors osthole and verbascoside alleviate UVB-induced skin inflammation and lesions in mice. ([FASEB Journal, 2023](https://pubmed.ncbi.nlm.nih.gov/37983944/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The application of a vitamin B12 and adenosine triphosphate complex improved skin radiance, elasticity, and texture in human participants. ([Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/39194754/))
- Direct delivery of intracellular adenosine triphosphate using ATP-encapsulated fusogenic small unilamellar lipid vesicles accelerated wound healing, improved granular tissue development, re-epithelialization, and increased vascular endothelial growth factor expression compared to lipid vesicles alone in adult nude mice. ([American Journal of Surgery, 2007](https://pubmed.ncbi.nlm.nih.gov/17236849/))
- A self-powered chloroplast-driven nanophotosystem consisting of Chlorella-derived nanothylakoid units and hyaluronic acid microneedles increased mitochondrial biogenesis, adenosine triphosphate generation, and NAD(P)H pools in senescent fibroblasts, leading to increased collagen synthesis and alleviated skin photoaging. ([Journal of Nanobiotechnology, 2026](https://pubmed.ncbi.nlm.nih.gov/42144642/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Angelica sinensis essential oil at 5%-10% demonstrated significant anti-acne effects comparable to adapalene gel with reduced side effects in mice by suppressing Cutibacterium acnes and downregulating IL-1β. ([Journal of Ethnopharmacology, 2026](https://pubmed.ncbi.nlm.nih.gov/41482092/))
- An Angelica sinensis extract containing 1% ligustilide demonstrated anti-inflammatory, antioxidant, anti-senescence, matrix-supportive, and antimicrobial effects in human keratinocytes and dermal fibroblasts. ([Frontiers in Pharmacology, 2026](https://pubmed.ncbi.nlm.nih.gov/41948733/))
- Topical application of Angelica sinensis extract induced noticeable hair regrowth, restored hair shaft lengths and follicle size, and decreased apoptotic cells in C57BL/6 mice. ([The American Journal of Chinese Medicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25004889/))
- Bacterial cellulose wound dressing containing silk sericin and PHMB improved wound quality and reduced pain compared to Bactigras in patients with split-thickness skin graft donor-site wounds. ([Archives of Dermatological Research, 2018](https://pubmed.ncbi.nlm.nih.gov/30302557/))
- A bacterial nanocellulose wound dressing incorporating polyhexamethylene biguanide and sericin showed no skin irritation in healthy volunteers and significantly promoted wound healing with lower wound size and higher collagen formation in full-thickness rat wounds compared to controls. ([Archives of Dermatological Research, 2016](https://pubmed.ncbi.nlm.nih.gov/26796543/))
- Topical application of sericin gels increased skin intrinsic moisturization, hydroxyproline content, and epidermal hydration while decreasing transepidermal water loss and skin impedance in healthy human volunteers. ([Journal of Cosmetic Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/17168872/))

## What reviewers say

Based on a very large amount of data, this product is highly regarded by users with aging, dry, and sensitive skin for its hydrating and plumping effects, visibly reducing fine lines. The lightweight gel formula is frequently praised for restoring the skin's moisture barrier and improving texture. However, some users with acne-prone skin report breakouts, and the high price is a common concern.

- Liked: Lightweight gel (mostly mentioned)
- Liked: Hydrating, plumping (often mentioned)
- Disliked: Very expensive (often mentioned)
- Liked: Gentle, soothing (sometimes noted)
- Liked: Reduces lines (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Causes breakouts (rarely noted)
- Disliked: Faulty pump (rarely noted)
- Disliked: Pills under makeup (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Growth Factor Serum a great fit for combination skin?

Growth Factor Serum is a great fit for your combination skin because it helps calm inflammation and balance oil while smoothing fine lines. The ingredients work safely to support skin renewal without causing irritation.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/), [Cellular and Molecular Biology, 2007](https://pubmed.ncbi.nlm.nih.gov/17543237/)

### Which ingredients make this serum a good fit for combination skin?

Buddleja Davidii Meristem Cell Culture and Dipeptide Diaminobutyroyl Benzylamide Diacetate make this serum a great fit because they work to reduce inflammation and regulate sebum, supporting skin regeneration and fine line reduction. Glycerin also helps by providing general hydration, and the formula is safe and unlikely to cause irritation on combination skin.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/), [Cellular and Molecular Biology, 2007](https://pubmed.ncbi.nlm.nih.gov/17543237/)

### What does Dipeptide Diaminobutyroyl Benzylamide Diacetate do for combination skin?

Dipeptide diaminobutyroyl benzylamide diacetate helps smooth the look of lines and wrinkles while improving overall skin quality on combination skin. Clinical studies show that serums containing this ingredient can successfully target signs of aging while keeping the skin safe and well-tolerated.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### What does Adenosine Triphosphate do for combination skin?

Adenosine triphosphate helps supply the energy that skin cells need to repair damage and stay healthy. For combination skin, this extra cellular energy supports normal cell renewal and helps keep both dry and oily areas balanced.
Sources: [Journal of Cellular Physiology, 2005](https://pubmed.ncbi.nlm.nih.gov/15389574/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/33594706/)

### Where does this serum go in a skincare routine for combination skin?

This treatment serum goes in the evening routine after cleansing and toning, and before moisturizing. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use it with retinol, and in what order?

You can use this treatment alongside retinol by applying it after your retinol and moisturizer in your evening routine, as it is safe and unlikely to cause irritation on your combination skin. Giving your skin a few minutes to absorb each layer helps everything sink in comfortably.

### How often should I use this serum?

This serum is used in the evening as part of your routine. It is a great fit for your combination skin and helps reduce inflammation while supporting skin regeneration and fine line reduction without causing irritation.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/), [Cellular and Molecular Biology, 2007](https://pubmed.ncbi.nlm.nih.gov/17543237/)

### Can it clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause breakouts on combination skin because it is safe and free of harsh ingredients that typically trigger irritation. Reviewers rarely complain about breakouts, and the formula includes ingredients that help calm inflammation and support skin health.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/), [Cellular and Molecular Biology, 2007](https://pubmed.ncbi.nlm.nih.gov/17543237/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Oleyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €37.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €380.10 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €129.99 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/it/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €13.50 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €18.47 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Cyclopentasiloxane, Dipropylene Glycol, Propylene Glycol, Dimethicone, Glycerin, Dimethicone Crosspolymer, Dimethicone Peg-10 15 Crosspolymer, Peg-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone Vinyl Dimethicone Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Magnesium Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Meristem Cell Culture, Angelica Polymorpha Sinensis Root Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus Panax Ginseng Root Extract Ferment Filtrate, Disodium Acetyl Glucosamine Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Parfum, Tocopherol, Beta-Glucan, Adenosine Triphosphate, Hydrolyzed Protein, Sodium Chloride, Xanthan Gum, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/zo-skin-health/growth-factor-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/zo-skin-health/growth-factor-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/zo-skin-health/growth-factor-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/zo-skin-health/growth-factor-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/zo-skin-health/growth-factor-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/combination-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/zo-skin-health/growth-factor-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/zo-skin-health/growth-factor-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/zo-skin-health/growth-factor-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/zo-skin-health/growth-factor-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/combination-skin