# ZO Skin Health Firming Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [ZO Skin Health](https://lovi.care/skincare/it/brands/zo-skin-health)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin due to Glycerin and Sodium DNA providing humectant action and barrier support, though it does not directly address your oily shine concerns.
- The firming and smoothing texture is enhanced by Caprooyl Tetrapeptide-3 and Retinyl Palmitate, offering visible anti-aging effects that complement general hydration from supportive ingredients like Propanediol.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of harsh ingredients and the inclusion of soothing agents like Tocopheryl Acetate.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/oily-acne-prone-skin): High

## Key ingredients

Retinyl Palmitate, Sodium Dna, Caprooyl Tetrapeptide-3, Leontopodium Alpinum Meristem Cell Culture, Tocopheryl Acetate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Retinyl palmitate-loaded non-ionic lamellar liquid crystalline systems provided a significant reduction of orbicular wrinkles in human volunteers compared to systems without retinyl palmitate. ([Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Polydeoxyribonucleotide treatment induces mitochondrial biogenesis while reducing melanin biosynthesis, tyrosinase activity, MITF expression, elastase activity, and MMP-1 gene expression in cultured skin cells. ([Applied Biochemistry and Biotechnology, 2020](https://pubmed.ncbi.nlm.nih.gov/31811642/))
- Leontopodium alpinum callus culture extract improved anti-periorbital wrinkles, skin elasticity, dermal density, skin thickness, antioxidant activity, and moisturizing activity while suppressing inflammation and wrinkling compared to placebo and in response to UVB treatment. ([Genes, 2020](https://pubmed.ncbi.nlm.nih.gov/32098197/))
- Leontopodium alpinum callus culture extract at 10-15 mg/mL promoted COL-I production and inhibited MMP-1, OPN3, ROS, and calcium influx in a blue-light-induced human foreskin fibroblast damage model, indicating an anti-blue-light-damage effect through the OPN3-calcium pathway. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/36903418/))
- A concentrated ethanol extract of Edelweiss callus culture (ECC55) protected primary human keratinocytes and endotheliocytes against various inflammatory and oxidative stimuli by inhibiting chemokine release, restoring sirtuin-inhibited cellular markers, and suppressing inflammation-related gene expression. ([Mediators of Inflammation, 2012](https://pubmed.ncbi.nlm.nih.gov/23093820/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))

## What reviewers say

This product is highly praised for its ability to visibly lift, tighten, and improve the structural integrity of aging skin. Users across various skin types report that the lightweight, hydrating formula effectively reduces the appearance of sagging jowls and fine lines, resulting in a more defined and youthful facial contour.

- Liked: Visible firming (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Improves texture (sometimes noted)
- Disliked: Minimal results (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes ZO Firming Serum a great fit for combination skin?

ZO Skin Health Firming Serum is a great fit for your combination skin because glycerin and sodium DNA keep it hydrated and support your skin barrier. Ingredients like caprooyl tetrapeptide-3 and retinyl palmitate help smooth your skin and offer visible anti-aging effects.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for combination skin?

Glycerin and Sodium DNA make this serum a great fit for your combination skin by holding in moisture and supporting your skin barrier. Ingredients like Retinyl Palmitate and Caprooyl Tetrapeptide-3 also help smooth and firm your skin while keeping it soft.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/)

### What does Retinyl Palmitate do for combination skin?

Retinyl palmitate helps smooth fine lines, even out skin tone, and improve texture on combination skin. Because it works gently, it is unlikely to cause irritation while helping keep both dry and oily areas looking clear and firm.
Sources: [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/), [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/)

### What does Sodium DNA do for combination skin?

Sodium DNA helps combination skin by improving skin barrier recovery and supporting elasticity. It is unlikely to cause irritation and may help keep the skin smooth and balanced.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps it simple and safe around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first in your evening routine, followed by your retinol product. This helps keep your skin smooth and firm while minimizing any potential irritation since this formula includes soothing agents.

### How often should I use this serum?

Use this serum in the evening as part of your routine for combination skin. It is unlikely to cause irritation and helps keep your skin smooth and firm.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause irritation, breakouts, or clogging for your combination skin due to the absence of harsh ingredients and the inclusion of soothing agents like Tocopheryl Acetate. It features ingredients like Glycerin and Sodium DNA that provide gentle moisture and barrier support.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum and limonene).

## Alternatives for combination skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €37.99 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/it/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €380.10 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — €129.99 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/it/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €13.50 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/combination-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/it/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €18.47 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Propanediol, Dipropylene Glycol, Sodium Dna, Leontopodium Alpinum Meristem Cell Culture, Marrubium Vulgare Meristem Cell Culture, Melilotus Officinalis Extract, Tocopheryl Acetate, Retinyl Palmitate, Caprooyl Tetrapeptide-3, Lecithin, Dextran, Hydroxypropyl Methylcellulose, Carbomer, Aminomethyl Propanol, Cellulose, Polysorbate 20, Caprylyl Glycol, Lactose, Ethylhexylglycerin, Hexylene Glycol, Disodium Edta, Citric Acid, Phenoxyethanol, Parfum, Ultramarines, Ext, Violet 2, Limonene
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/zo-skin-health/firming-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/zo-skin-health/firming-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/zo-skin-health/firming-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/zo-skin-health/firming-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/zo-skin-health/firming-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/combination-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/zo-skin-health/firming-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/zo-skin-health/firming-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/zo-skin-health/firming-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/zo-skin-health/firming-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/zo-skin-health/firming-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/zo-skin-health/firming-serum/for/combination-skin