ZO Skin Health Enzymatic Peel for skin with dark spots

How to apply

Questions and answers

What the research says

• Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks.

  International Journal of Dermatology, 2000

• Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone.

  Dermatologic Surgery, 2017

• Oral bromelain slightly reduced pain compared to controls (mean difference -0.27) and topical bromelain reduced time to complete debridement by 6.89 days, with no major health risks reported.

  Nutrition and Health, 2023

• An upcycled pineapple leaf fibre crosspolymer forms a physical barrier that protects against environmental aggressors while providing antioxidant, anti-inflammatory, antipollution, UV protection, hydration, and hair benefits.

  International Journal of Cosmetic Science, 2026

• A coaxial electrospun core-shell nanofiber scaffold delivering bromelain and salvianolic acid B demonstrated sustained drug release, in vitro endothelial cell migration, increased capillary formation in an in ovo assay, and in vivo efficacy for skin regeneration and wound healing.

  Biomedical Materials, 2017

• Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo.

  Wilderness & Environmental Medicine, 2016

• A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face.

  Giornale Italiano Di Dermatologia E Venereologia, 2015

• Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation.

  Molecules, 2020

• Topical sulforaphane treatment reduced mottled skin pigmentation in humans and UV-induced pigmentation in wild-type mice through NRF2 and keratinocyte-specific IL-6Rα signaling.

  JCI Insight, 2020

• Topical application of sulforaphane-rich broccoli sprout extracts reduced UVR-induced erythema by a mean of 37.7% in six human subjects.

  Proceedings of the National Academy of Sciences of the United States of America, 2007

• Pre-treatment with sulforaphane and phenylethyl isothiocyanate significantly counteracted UVR-induced increases in apoptosis and decreases in catalase in human skin by inducing Nrf2-dependent antioxidant pathways.

  Pharmacological Research, 2013

Ingredients

Water, Cyclopentasiloxane, Glycolic Acid, Dimethicone, Methylheptyl Isostearate, Cetyl Alcohol, Diglycerin, Dimethicone Crosspolymer, Glyceryl Stearate, Peg-100 Stearate, Isohexadecane, Helianthus Annuus Seed Oil Sunflower Seed Oil, Dimethiconol, Carthamus Tinctorius Seed Oil, Maltodextrin, Aleurites Moluccana Seed Oil, Brassica Oleracea Italica Extract, Oleth-20, Bromelain, Algin, Tocopherol, Papain, Xanthan Gum, Carbomer, Disodium Edta, Caprylyl Glycol, 1,2-Hexanediol, Ascorbyl Palmitate, Sodium Hydroxide, Phenoxyethanol, Chlorphenesin

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.