# VT Cosmetics PDRN Essence 100 for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [VT Cosmetics](https://lovi.care/skincare/it/brands/vt-cosmetics)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your dry skin as sodium hyaluronate and glycerin provide humectant action, while panthenol and allantoin support barrier repair, addressing your dry or flaky skin concerns.
- The presence of PDRN and sodium hyaluronate offers excellent skin regeneration for plumping and enhancing barrier resilience.
- The formula is safe for your dry skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/oily-acne-prone-skin): High

## Key ingredients

Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Niacinamide, Adenosine

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Plant-derived polydeoxyribonucleotide from Panax ginseng promoted skin wound healing and enhanced the skin barrier by stimulating keratinocyte and fibroblast proliferation in skin cells and an artificial skin model. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37959659/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

Based on a very large amount of data, users with dry, sensitive, and combination skin highly praise this essence for its ability to deliver a glass skin finish and deep hydration without irritation. It is widely celebrated for restoring compromised barriers and plumping fine lines. A minority of users with oily skin find the texture too heavy or tacky.

- Liked: Hydration and glow (mostly mentioned)
- Liked: Soothing and repair (often mentioned)
- Liked: Fragrance-free (sometimes noted)
- Liked: Good texture (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Liked: Nice packaging (rarely noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Expensive price (rarely noted)
- Disliked: Pump design (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes VT COSMETICS PDRN Essence 100 a great fit for dry skin?

VT COSMETICS PDRN Essence 100 is a great fit because sodium hyaluronate and glycerin pull moisture into dry skin, while panthenol and allantoin help repair the skin barrier. PDRN and sodium hyaluronate also support skin regeneration to plump up the skin and make its barrier stronger.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this treatment a good fit for dry skin?

Sodium hyaluronate and glycerin pull moisture into dry skin, while panthenol and allantoin help repair the skin barrier. PDRN further supports barrier strength and plumps the skin, making this treatment a great match.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does PDRN do for dry skin?

PDRN helps repair the outer skin barrier and boosts moisture retention to keep dry skin soft and smooth. It also supports skin regeneration and collagen production, which may reduce signs of aging.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/)

### What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this treatment go in a skincare routine for dry skin?

This treatment goes in the evening routine for dry skin, after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and helps avoid extra sensitivity around sun exposure.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first in your evening routine, followed by your moisturizer. This helps keep your dry skin soft and smooth while supporting barrier recovery.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this treatment?

Apply this treatment in your evening routine, using it after cleansing and before your moisturizer. It is safe for daily use and helps keep dry skin plump and hydrated.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can this treatment clog pores, cause breakouts or purging for dry skin?

VT COSMETICS PDRN Essence 100 is unlikely to cause breakouts for dry skin, as it has a low risk of doing so. The formula features gentle, hydrating ingredients that support your skin without clogging pores.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/it/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €20.29 at Amazon
- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/it/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — €48.70 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/it/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €9.19 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — €15.16 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €53.50 at Amazon

## Where to buy

- Amazon.it: €27.22 (https://www.amazon.it/dp/B0CRKPZ9PQ?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Notino: €36.00 (https://www.notino.it/vt-cosmetics/pdrn-100-essence-essenza-viso-rigenerante-effetto-idratante/p-16345771/)
- Lookfantastic: €40.00 (https://www.lookfantastic.it/p/vt-cosmetics-pdrn-essence-100/17620559/)
Prices checked 25 Oct – 6 Nov 2026.

## Ingredients

Water, Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Glycerin, Butylene Glycol, Niacinamide, Panthenol, Allantoin, Adenosine, Betaine, Phenoxyethanol, Ethylhexylglycerin, Carbomer, Triethanolamine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- France: https://lovi.care/skincare/fr/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/dry-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/vt-cosmetics/pdrn-essence-100/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/vt-cosmetics/pdrn-essence-100/for/dry-skin