# The Ordinary Retinol 0.5% in Squalane for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: High · Safety: Concerning.

Page: https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [The Ordinary](https://lovi.care/skincare/it/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate anti-aging benefits for your normal skin as retinol supports skin renewal and squalane provides emollient action, though it may not deliver optimal results in all areas.
- The presence of jojoba seed oil and tomato fruit extract offers additional nourishment and antioxidant protection.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Squalane, Caprylic Capric Triglyceride, Jojoba Seed Oil, Solanum Lycopersicum Fruit Extract Tomato Fruit Extract

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical application of jojoba wax reduced LPS-induced secretion of IL-6, IL-8, and TNFα by approximately 30% and increased the synthesis of pro-collagen III and hyaluronic acid compared to untreated skin in an ex-vivo human skin organ culture model. ([Frontiers in Pharmacology, 2024](https://pubmed.ncbi.nlm.nih.gov/38344180/))
- Topical delivery of lycopene via MG- and TG-containing microemulsions significantly increased stratum corneum and viable skin layer penetration compared to a control solution, with the MG-containing microemulsion also increasing skin antioxidant activity by 10-fold. ([Journal of Pharmaceutical Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/19798758/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of an emollient emulsion containing 15.0% caprylic/capric triglyceride doubled the amount of urocanic acid isomers and increased skin hydration with reduced transepidermal water loss in healthy subjects, though it did not prevent ultraviolet-induced urocanic acid isomerization. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/37109405/))
- Clay jojoba oil facial masks reduced total skin lesions by a mean of 54% after 6 weeks in 133 participants with acne-prone, lesioned skin and mild acne compared to baseline. ([Forschende Komplementarmedizin, 2012](https://pubmed.ncbi.nlm.nih.gov/22585103/))
- Topical jojoba oil application in male mice decreased exercise-induced pro-inflammatory gene expression (Il-1b and Il-6 in soleus, Il-1b in gastrocnemius) compared to untreated exercised mice. ([Biomolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41154623/))
- Nanolipidgel formulations with argan or jojoba oil and humectants demonstrate good sensory attributes, instrumental properties, and moisturizing efficacy for cosmetic application. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24772476/))
- Topical lycopene-based emulgel significantly enhanced skin hydration and elasticity while reducing erythema, melanin, and sebum contents in human volunteers compared to a placebo formulation over 12 weeks. ([European Journal of Pharmaceutics and Biopharmaceutics, 2022](https://pubmed.ncbi.nlm.nih.gov/36283632/))
- Cosmetic formulations containing lycopene and melatonin showed significant differences in skin sebum content, hydration, elasticity, erythema index, and melanin index compared to control in 36 healthy women. ([Skin Pharmacology and Physiology, 2020](https://pubmed.ncbi.nlm.nih.gov/33070140/))
- Tomato-derived nanovesicles and extract accelerated wound closure and increased cell migration in human keratinocytes and mouse fibroblasts without affecting cell proliferation. ([International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/38473700/))

## What reviewers say

Based on a very large amount of data, users generally praise this serum as an affordable and effective entry-level retinol that improves skin texture and reduces fine lines, though the oily squalane base is a polarizing feature. While many with dry or mature skin appreciate the added hydration, those with oily or acne-prone skin frequently report that it feels heavy, greasy, and can cause congestion or purging.

- Liked: Improves skin texture (mostly mentioned)
- Liked: Unbeatable price (mostly mentioned)
- Liked: Hydrating formula (often mentioned)
- Liked: Reduces aging signs (often mentioned)
- Disliked: Greasy residue (often mentioned)
- Liked: Gentle effectiveness (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Short shelf life (sometimes noted)
- Disliked: Messy packaging (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does The Ordinary Retinol 0.5% in Squalane work for mature skin?

This product works moderately well for mature skin, helping to renew the skin and keep it soft. To fit this skin better, a product of this type needs exceptional safety without irritation, high-quality ingredients that target fine lines and wrinkles, and a rich blend of antioxidants, peptides, and humectants for optimal elasticity and moisture.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Which ingredients make this serum a good fit for mature skin?

Retinol and squalane make this serum a good fit for mature skin as retinol supports skin renewal and squalane keeps your skin soft and smooth. To work best for mature skin, a product of this type needs high-quality ingredients that target wrinkles with no risk of irritation, powerful antioxidants, and hydrating components that improve skin elasticity and moisture retention.

### What does Retinol do for mature skin?

Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Squalane do for mature skin?

Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/)

### Where does this serum go in a skincare routine for mature skin?

Put this treatment in your evening routine, using it after your cleanser and before your moisturizer. Mature skin needs products with retinol to support skin renewal, along with nourishing oils and antioxidants to keep it soft and smooth.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C by applying vitamin C in the morning and this retinol treatment at night to avoid overwhelming your skin. This spacing helps prevent irritation while supporting your skin renewal and anti-aging routine safely.

### How often should I use this serum?

Use this treatment in your evening routine once a week to start, as retinol helps skin renewal while keeping irritation low. If your skin feels comfortable and looks smooth, you may gradually use it more often. Mature skin also benefits from heavier anti-aging treatments that combine powerful collagen-boosting actives with deep moisturizers for optimal results.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

Yes, this serum may cause breakouts or clog pores for mature skin, as reviewers moderately complain about breakouts and the formula contains rich oils like jojoba seed oil. Mature skin with this concern needs a treatment providing retinol for skin renewal alongside lightweight, non-pore-clogging hydrators.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €129.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €34.95 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/it/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €24.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/it/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €16.03 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/it/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €53.50 at Amazon

## Where to buy

- Lookfantastic: €9.66 (https://www.lookfantastic.it/p/the-ordinary-retinol-serum-0.5-in-squalane-30ml/11638502/)
Prices checked 17 Oct 2026.

## Ingredients

Squalane, Caprylic Capric Triglyceride, Jojoba Seed Oil, Retinol, Solanum Lycopersicum Fruit Extract Tomato Fruit Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Hydroxymethoxyphenyl Decanone, Bht
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- France: https://lovi.care/skincare/fr/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin (this page)
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/retinol-0-5-in-squalane/for/mature-skin