# The Ordinary Multi-Peptide + HA Serum for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [The Ordinary](https://lovi.care/skincare/it/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other serums fit it better.

## Why this fit

- Offers moderate plumping and firming benefits for your normal skin due to multiple peptides like Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1, which support collagen production and skin elasticity. While Glycerin and Sodium Hyaluronate Crosspolymer provide excellent hydration, the formula does not directly target your primary concern of pigmentation.
- The inclusion of Allantoin and various amino acids offers general skin soothing and barrier support, contributing to overall skin health for your normal skin type.
- The product is safe for your normal skin, as it contains no harsh ingredients and includes soothing components like Allantoin and Glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Multi-Peptides, Sodium Hyaluronate, Lactococcus Lysate Ferment, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## Why other serums fit skin with dark spots better

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Based on a very large amount of data, users with dry, mature, or dehydrated skin frequently praise this serum for its ability to plump the skin and smooth texture, often noting a reduction in fine dehydration lines. While many appreciate it as an affordable "all-in-one" anti-aging solution, a minority of users report breakouts or a lack of visible results regarding deeper wrinkles.

- Liked: Deeply hydrates (mostly mentioned)
- Liked: Great value (often mentioned)
- Liked: Smooths texture (often mentioned)
- Liked: Plumps and firms (sometimes noted)
- Liked: Reduces fine lines (sometimes noted)
- Disliked: Conflicts with actives (sometimes noted)
- Disliked: Unclear results (sometimes noted)
- Disliked: Allergic reactions (rarely noted)
- Disliked: Causes breakouts (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does The Ordinary Multi-Peptide + HA Serum work for skin with dark spots?

This serum works moderately well for your skin, though other products fit it better because it does not directly target dark spots. A treatment for this skin needs effective antioxidants, soothing ingredients, and brightening components like niacinamide to fade dark spots without irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum does not contain ingredients that directly target dark spots, as its formula focuses on peptides and hydrating components like glycerin and sodium hyaluronate. A treatment for skin with dark spots needs effective antioxidants and soothing ingredients like niacinamide and propolis to fade discoloration safely.

### What do Peptides do for skin with dark spots?

Peptides help brighten skin and fade dark spots by targeting pigment production, improving uneven skin tone, and supporting a smoother, more radiant complexion. They generally have a good safety profile and are unlikely to cause irritation when used in your daily routine.
Sources: [Fish Physiology and Biochemistry, 2017](https://pubmed.ncbi.nlm.nih.gov/28130732/), [Biomaterials, 2014](https://pubmed.ncbi.nlm.nih.gov/24602570/)

### What does Hyaluronic Acid do for skin with dark spots?

Hyaluronic acid is unlikely to directly fade dark spots, but it helps keep dry and uneven skin plump and deeply hydrated. To effectively target dark spots, this type of skin needs brightening ingredients like vitamin C or niacinamide alongside your hydrator.

### Where does this serum go in a skincare routine for skin with dark spots?

This serum goes in the evening routine before your moisturizer. A product for dark spots needs brightening ingredients like vitamin C or niacinamide to help fade discoloration.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to give your skin hydration and peptides, followed by your retinol. This product helps support overall skin health with soothing ingredients like allantoin and glycerin, but for skin with dark spots, a treatment that directly targets pigmentation is needed.

### How often should I use this serum?

This serum works well in the evening for your routine. A product for skin with dark spots needs dedicated brightening ingredients like vitamin C, niacinamide, or alpha arbutin to effectively fade discoloration.

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores or cause breakouts for skin with dark spots, as reviewer complaints about breakouts are low and the formula contains gentle, soothing ingredients like glycerin and allantoin. A product for this skin needs direct brightening ingredients and antioxidants to effectively fade dark spots.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — €57.00 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/it/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — €132.56 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/dark-spots) — High fit — €396.14 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €24.75 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €15.16 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/dark-spots) — Superior fit — €18.06 at Amazon

## Where to buy

- Amazon.it: €17.89 (https://www.amazon.it/dp/B0BLHW7JZM?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €33.24 (https://www.lookfantastic.it/p/the-ordinary-multi-peptide-copper-peptides-1-serum-30ml/14853143/)
Prices checked 15 Oct – 3 Nov 2026.

## Ingredients

Water, Glycerin, Lactococcus Lysate Ferment, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium Pca, Pca, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, Ppg-26-Buteth-26, Peg-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots (this page)
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots