# The INKEY List Niacinamide Serum for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: [The INKEY List](https://lovi.care/skincare/it/brands/the-inkey-list)
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other serums fit it better.

## Why this fit

- This serum offers moderate benefits for your normal skin, with niacinamide helping to regulate oil and glycerin providing hydration, though it lacks specialized ingredients for your pigmentation concerns.
- Panthenol and allantoin offer supportive benefits for overall skin health and hydration, contributing to a smoother complexion.
- The formula is safe for your normal skin, as it contains soothing ingredients like niacinamide and panthenol and avoids harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Glycerin, Squalane, Sodium Hyaluronate, Leuconostoc Radish Root Ferment Filtrate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## Why other serums fit skin with dark spots better

- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Based on a very large amount of data, users with oily and blemish-prone skin frequently praise this serum for its ability to regulate sebum production and calm active breakouts without stripping moisture. The majority report clearer skin and reduced redness. A notable minority experience texture issues, such as a sticky finish or white residue if the product is not applied carefully.

- Liked: Controls excess oil (often mentioned)
- Liked: Great value & packaging (often mentioned)
- Liked: Reduces redness & blemishes (often mentioned)
- Liked: Hydrating & lightweight (sometimes noted)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Sticky or tacky finish (sometimes noted)
- Disliked: White residue/crystallization (sometimes noted)
- Disliked: Caused breakouts/irritation (rarely noted)
- Disliked: Foaming/soaping effect (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does The INKEY List Niacinamide work for skin with dark spots?

This serum works moderately well for your skin, as niacinamide helps control oil and glycerin provides hydration, though it lacks specialized ingredients for dark spots. To better address dark spots, a product of this type needs a blend of effective antioxidants and targeted brightening ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum contains niacinamide to help regulate oil and glycerin to provide hydration, though it lacks specialized ingredients for your dark spots. To better fit skin with dark spots, a product of this type needs effective antioxidants and soothing ingredients that provide significant benefits for pigmentation concerns without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for skin with dark spots?

Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Glycerin do for skin with dark spots?

Glycerin helps keep dry skin hydrated and supports a healthy skin barrier, which makes skin feel soft and smooth. While it does not directly fade dark spots on its own, it is often added to spot-fading products to keep the skin comfortable while other ingredients work.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Acta Dermato-venereologica, 2017](https://pubmed.ncbi.nlm.nih.gov/27349297/)

### Where does this serum go in a skincare routine for skin with dark spots?

Apply this treatment serum in the evening after cleansing and before moisturizing. This product of this type needs targeted brightening ingredients like vitamin C, retinoids, or gentle acids to effectively address dark spots.

### Can I use it with retinol, and in what order?

You can use this serum with retinol by applying the treatment after cleansing and toning, and before your moisturizer. It is unlikely to irritate your skin when paired properly, but this product needs targeted brightening ingredients to effectively address dark spots.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. Products for skin with dark spots need targeted ingredients like vitamin C, retinoids, or alpha arbutin to effectively fade discoloration.

### Can it clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to cause breakouts, as only a small number of reviewers report any irritation or pimples, and it avoids harsh ingredients. To properly care for dark spots, this skin needs targeted brightening ingredients and gentle exfoliants that fade discoloration.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — €57.00 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/it/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — €132.56 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/dark-spots) — High fit — €396.14 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €24.75 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €15.16 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/dark-spots) — Superior fit — €18.06 at Amazon

## Where to buy

- Amazon.it: €9.99 (https://www.amazon.it/dp/B09PP2DK5W?tag=lovi-care-web-product09-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Niacinamide, Glycerin, Propanediol, Butylene Glycol, Phenoxyethanol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyethylcellulose, Squalane, Xanthan Gum, Glycine Soja Oil Soybean Oil, Allantoin, Sodium Phytate, Polysorbate 60, Panthenol, Glycolipids, Leuconostoc Radish Root Ferment Filtrate, Sorbitan Isostearate, Glycine Soja Soybean Sterols, Citric Acid, Sodium Hyaluronate, Disodium Phosphate, Sodium Phosphate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-inkey-list/niacinamide-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/the-inkey-list/niacinamide-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/the-inkey-list/niacinamide-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/the-inkey-list/niacinamide-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/the-inkey-list/niacinamide-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/the-inkey-list/niacinamide-serum/for/dark-spots (this page)
- Netherlands: https://lovi.care/skincare/nl/p/the-inkey-list/niacinamide-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/the-inkey-list/niacinamide-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/the-inkey-list/niacinamide-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/the-inkey-list/niacinamide-serum/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/the-inkey-list/niacinamide-serum/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-inkey-list/niacinamide-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-inkey-list/niacinamide-serum/for/dark-spots