# The History of Whoo Bichup Self-Generating Anti-Aging Concentrate for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: The History of Whoo
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other serums fit it better.

## Why this fit

- Suitable for normal skin, this formulation contains Panax Ginseng Root Extract and Niacinamide, which provide antioxidant activity and support barrier repair, aligning well with your skin type.
- The presence of oligopeptides and acetyl hexapeptide-8 offers moderate anti-aging benefits by improving skin elasticity and reducing fine lines, though it does not directly address your pigmentation concerns.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Ceramide Np, Panax Ginseng Root Extract, Copper Tripeptide-1, Hydrolyzed Soy Protein

## What the research says

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects. ([Rejuvenation Research, 2015](https://pubmed.ncbi.nlm.nih.gov/25867599/))
- A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects. ([Journal of Ginseng Research, 2022](https://pubmed.ncbi.nlm.nih.gov/35509819/))
- A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline. ([Journal of Toxicology and Environmental Health. Part A, 2020](https://pubmed.ncbi.nlm.nih.gov/32564709/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))

## Why other serums fit skin with dark spots better

- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Many users report plumper, firmer skin with diminished fine lines. However, some find the texture sticky and the floral fragrance overpowering.

- Liked: Deep hydration (often mentioned)
- Liked: Radiant glow (often mentioned)
- Disliked: Strong fragrance (often mentioned)
- Liked: Plumping effect (sometimes noted)
- Liked: Soothing & healing (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Sticky texture (sometimes noted)
- Disliked: Awkward packaging (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Whoo Bichup Self-Generating Anti-Aging Concentrate work for skin with dark spots?

This treatment works for skin with dark spots, though other products fit this skin better. A product of this type needs targeted ingredients that directly fade dark spots and brighten uneven skin tone.

### Which ingredients make this serum a good fit for skin with dark spots?

Niacinamide makes this serum a good fit for skin with dark spots. Skincare products that fit this skin best need a blend of effective antioxidants and soothing ingredients that provide significant benefits for dark spots without any risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### What does Niacinamide do for skin with dark spots?

Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What do Ceramides do for skin with dark spots?

Ceramides help keep your skin barrier strong and well-hydrated, which supports overall skin health even though they do not directly fade dark spots. A product for dark spots also needs ingredients like niacinamide or vitamin C to help brighten your skin tone and reduce discoloration.
Sources: [International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/), [Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/37717558/)

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. To better target dark spots, this skin type needs a product with brightening ingredients like vitamin C, alpha arbutin, or retinoids.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol, applying the treatment first and following with retinol once it absorbs. This product is unlikely to cause irritation for your skin, but combining active ingredients may occasionally lead to mild dryness.

### How often should I use this serum?

You can use this treatment serum every evening, as this fits well into your routine for simplicity and extra safety around sun exposure. Since it does not directly target your dark spots, skin with dark spots also needs brightening ingredients like vitamin C or alpha arbutin to effectively even out your skin tone.

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This treatment is unlikely to clog pores or cause breakouts for your skin, though it does not specifically target dark spots. For better results with pigmentation, this skin needs targeted brightening ingredients like vitamin C, alpha arbutin, or tranexamic acid.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl salicylate, citronellol, geraniol, limonene, and linalool).

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/it/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — €57.00 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/it/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — €132.56 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/dark-spots) — High fit — €396.14 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/it/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €24.75 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/it/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €15.16 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/dark-spots) — Superior fit — €18.06 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Dipropylene Glycol, Peg Ppg Polybutylene Glycol-8 5 3 Glycerin, Glyceryl Polymethacrylate, Biosaccharide Gum-1, Dimethicone, 1,2-Hexanediol, Peg-150, Propylene Glycol, Phenyl Trimethicone, Panthenol, Methyl Trimethicone, Cordyceps Sinensis Extract, Nelumbo Nucifera Extract, Nuphar Japonicum Root Extract, Panax Ginseng Root Extract, Ophiopogon Japonicus Root Extract, Rehmannia Chinensis Root Extract, Poria Cocos Extract, Dioscorea Japonica Root Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Typha Angustifolia Spike Extract, Paeonia Albiflora Extract, Scutellaria Baicalensis Root Extract, Angelica Gigas Extract, Saposhnikovia Divaricata Root Extract, Atractylodes Japonica Root Extract, Cinnamomum Cassia Bark Extract, Zingiber Officinale Root Extract, Ziziphus Jujuba Fruit Extract, Angelica Acutiloba Root Extract, Cornus Officinalis Fruit Extract, Velvet Extract, Theobroma Cacao Extract, Thymus Vulgaris Extract, Hydroxyproline, Ceramide Np, Cholesterol, Arbutin, Oligopeptide-1, Oligopeptide-2, Oligopeptide-4, Hydrolyzed Soy Protein, Acetyl Hexapeptide-8, Copper Tripeptide-1, Arginine, Cystine, Histidine Hcl, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Tyrosine, Valine, Biotin, Folic Acid, Inositol, Niacinamide, Calcium Pantothenate, Pyridoxine Hcl, Riboflavin, Thiamine Hcl, Cyanocobalamin, Glycosphingolipids, Beta-Glucan, Hydrogenated Lecithin, Peg-10 Rapeseed Sterol, Glyceryl Stearate, Glycereth-20, C14-22 Alcohols, Phytosqualane, Macadamia Ternifolia Seed Oil, Triethylhexanoin, Arachidyl Glucoside, Butyrospermum Parkii Butter Shea Butter, Stearic Acid, Peg-100 Stearate, Polymethylsilsesquioxane, Cyclopentasiloxane, Dimethiconol, Butylene Glycol, Peg-60 Hydrogenated Castor Oil, Carbomer, Algin, Sodium Polyacrylate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Sunset Yellow Fcf, Tartrazine, Tromethamine, Trisodium Edta, Alpha-Isomethyl Ionone, Benzyl Salicylate, Citronellol, Geraniol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

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- United Kingdom: https://lovi.care/skincare/uk/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/dark-spots
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