# The History of Whoo Bichup Self-Generating Anti-Aging Concentrate for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Italy.

Brand: The History of Whoo
Category: [Serums and treatments](https://lovi.care/skincare/it/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate anti-aging benefits for your combination skin due to oligopeptides and acetyl hexapeptide-8, which help minimize fine lines and wrinkles.
- While glycerin and biosaccharide gum-1 provide hydration, the formula lacks targeted ingredients for your acne, blemishes, and breakouts.
- The product is safe for your combination skin with no risks of irritation from harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/it/p/the-history-of-whoo/bichup-self-generating-anti-aging-concentrate/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Ceramide Np, Panax Ginseng Root Extract, Copper Tripeptide-1, Hydrolyzed Soy Protein

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects. ([Rejuvenation Research, 2015](https://pubmed.ncbi.nlm.nih.gov/25867599/))
- A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects. ([Journal of Ginseng Research, 2022](https://pubmed.ncbi.nlm.nih.gov/35509819/))
- A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline. ([Journal of Toxicology and Environmental Health. Part A, 2020](https://pubmed.ncbi.nlm.nih.gov/32564709/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Many users report plumper, firmer skin with diminished fine lines. However, some find the texture sticky and the floral fragrance overpowering.

- Liked: Deep hydration (often mentioned)
- Liked: Radiant glow (often mentioned)
- Disliked: Strong fragrance (often mentioned)
- Liked: Plumping effect (sometimes noted)
- Liked: Soothing & healing (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Sticky texture (sometimes noted)
- Disliked: Awkward packaging (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Whoo Bichup Anti-Aging Concentrate work for acne-prone skin?

This treatment works moderately well for acne-prone skin, though other products fit it better because it lacks targeted ingredients for breakouts. A product of this type needs effective ingredients like niacinamide, propolis, or zinc PCA to clear acne while keeping the skin balanced.

### Which ingredients make this serum a good fit for acne-prone skin?

This treatment works for your acne-prone skin, though other products fit it better because it lacks targeted ingredients for acne and breakouts. To truly support acne-prone skin, a product of this type needs soothing ingredients like niacinamide and propolis that target blemishes and control oiliness without causing irritation.

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### What do Ceramides do for acne-prone skin?

Ceramides help acne-prone skin by restoring a weak water barrier, which is often damaged and low in these protective lipids in people with acne. Using them helps reduce dryness, redness, and irritation caused by acne treatments while keeping the skin calm and smooth.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/), [Archives of Dermatological Research, 1995](https://pubmed.ncbi.nlm.nih.gov/7763094/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Acne-prone skin needs a product of this type that also includes targeted blemish-fighting ingredients such as salicylic acid or benzoyl peroxide.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying the serum first, waiting for it to absorb, and then following with your retinol product. This approach helps keep your skin calm while supporting your anti-aging routine, though this product type needs ingredients like salicylic acid or benzoyl peroxide to properly target acne-prone skin.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. While it offers moderate anti-aging benefits, acne-prone skin needs soothing and blemish-clearing ingredients like salicylic acid, tea tree oil, or azelaic acid to effectively manage breakouts.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This treatment is unlikely to cause purging, but because it lacks targeted blemish-fighting ingredients, it may not prevent breakouts for acne-prone skin. Acne-prone skin needs products with soothing botanicals and blemish-clearing ingredients like salicylic acid or benzoyl peroxide to keep pores clear.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl salicylate, citronellol, geraniol, limonene, and linalool).

## Alternatives for acne-prone skin

- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €37.99 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/it/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €129.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/it/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — €35.10 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/it/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.43 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/it/p/la-mer/the-tonic/for/acne-prone-skin) — Superior fit — €103.91 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/it/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €18.06 at Amazon

## Where to buy

No store in Italy has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Dipropylene Glycol, Peg Ppg Polybutylene Glycol-8 5 3 Glycerin, Glyceryl Polymethacrylate, Biosaccharide Gum-1, Dimethicone, 1,2-Hexanediol, Peg-150, Propylene Glycol, Phenyl Trimethicone, Panthenol, Methyl Trimethicone, Cordyceps Sinensis Extract, Nelumbo Nucifera Extract, Nuphar Japonicum Root Extract, Panax Ginseng Root Extract, Ophiopogon Japonicus Root Extract, Rehmannia Chinensis Root Extract, Poria Cocos Extract, Dioscorea Japonica Root Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Typha Angustifolia Spike Extract, Paeonia Albiflora Extract, Scutellaria Baicalensis Root Extract, Angelica Gigas Extract, Saposhnikovia Divaricata Root Extract, Atractylodes Japonica Root Extract, Cinnamomum Cassia Bark Extract, Zingiber Officinale Root Extract, Ziziphus Jujuba Fruit Extract, Angelica Acutiloba Root Extract, Cornus Officinalis Fruit Extract, Velvet Extract, Theobroma Cacao Extract, Thymus Vulgaris Extract, Hydroxyproline, Ceramide Np, Cholesterol, Arbutin, Oligopeptide-1, Oligopeptide-2, Oligopeptide-4, Hydrolyzed Soy Protein, Acetyl Hexapeptide-8, Copper Tripeptide-1, Arginine, Cystine, Histidine Hcl, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Tyrosine, Valine, Biotin, Folic Acid, Inositol, Niacinamide, Calcium Pantothenate, Pyridoxine Hcl, Riboflavin, Thiamine Hcl, Cyanocobalamin, Glycosphingolipids, Beta-Glucan, Hydrogenated Lecithin, Peg-10 Rapeseed Sterol, Glyceryl Stearate, Glycereth-20, C14-22 Alcohols, Phytosqualane, Macadamia Ternifolia Seed Oil, Triethylhexanoin, Arachidyl Glucoside, Butyrospermum Parkii Butter Shea Butter, Stearic Acid, Peg-100 Stearate, Polymethylsilsesquioxane, Cyclopentasiloxane, Dimethiconol, Butylene Glycol, Peg-60 Hydrogenated Castor Oil, Carbomer, Algin, Sodium Polyacrylate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Sunset Yellow Fcf, Tartrazine, Tromethamine, Trisodium Edta, Alpha-Isomethyl Ionone, Benzyl Salicylate, Citronellol, Geraniol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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