Sunday Riley U.F.O. Ultra-Clarifying Face Oil for acne-prone skin

How to apply

Questions and answers

What the research says

• A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase.

  BioMed Research International, 2020

• Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability.

  Journal of Cosmetic Dermatology, 2024

• The use of a salicylic acid-based dermocosmetic significantly reduces the needed quantity of benzoyl peroxide without impacting efficacy in mild to moderate acne, and as maintenance post-benzoyl peroxide allows a significant reduction of acne relapse compared to vehicle.

  Journal of Drugs in Dermatology, 2023

• Topical thymoquinone attenuated TPA-induced COX-2 expression and NF-kappaB activation and induced cytoprotective enzyme expression in female HR-1 hairless mouse skin.

  Biochemical and Biophysical Research Communications, 2013

• An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.

  Clinical, Cosmetic and Investigational Dermatology, 2019

• Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients.

  CMAJ, 2010

• Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy.

  Journal of Cosmetic Dermatology, 2024

• Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients.

  Journal of the American Academy of Dermatology, 2010

• Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.

  Evidence-based Complementary and Alternative Medicine, 2015

• Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.

  Experimental Dermatology, 2015

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

• Thymoquinone-loaded liposomal chitosan gel demonstrated superior in vivo anti-inflammatory activity over thymoquinone gel and a comparable effect to marketed indomethacin gel in rats with carrageenan-induced paw edema.

  AAPS PharmSciTech, 2018

• Thymoquinone pre-treatment attenuated UVA-induced oxidative stress, inflammation, and mitochondrial apoptosis in human HaCaT keratinocytes through COX-2 inhibition via the activation of the NrF2/ARE pathway.

  Molecular Immunology, 2021

• Topical application of thymoquinone treated with cold plasma significantly improved wound healing potential, augmenting skin regeneration indices, reducing tumor necrosis factor-alpha, and enhancing hyaluronic acid, collagen type I, interleukin-10, alpha smooth muscle actin, and vascular endothelial growth factor compared to thymoquinone alone in a rat wound model.

  International Immunopharmacology, 2023

• Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group.

  Journal of Cosmetic Dermatology, 2024

• Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events.

  Journal of Cosmetic Dermatology, 2023

• Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris.

  Journal of Cutaneous Medicine and Surgery, 2024

Ingredients

Silybum Marianum Seed Oil Milk, Nigella Sativa Seed Oil, Cucumis Sativus Seed Oil, Punica Granatum Seed Oil, Diisopropyl Sebacate, Cranberry Seed Oil, Dimethyl Isosorbide, Linum Usitatissimum Seed Oil, Caprylic Capric Triglyceride, Glycyrrhiza Glabra Licorice Root Extract, Prunus Armeniaca Apricot Kernel Oil, Hexylresorcinol, Ethyl Linoleate, Melia Azadirachta Leaf Extract, Chamomilla Recutita Oil Flower, Citrus Aurantium Amara Oil Flower, Melia Azadirachta Neem Flower Extract, Helianthus Annuus Sunflower Seed Oil, 4-Terpineol, Linalool, Coccinia Indica Fruit Extract, Limonene, Solanum Melongena Fruit Extract, Amber Powder, Curcuma Longa Root Extract, Ocimum Sanctum Leaf Extract, Isopropyl Alcohol, Aloe Barbadensis Flower Extract, Corallina Officinalis Extract, Rosmarinus Officinalis Rosemary Leaf Extract, Moringa Oleifera Seed Oil, Tocopherol, Farnesol, Geraniol, Water, Grapefruit Peel Oil, Ocimum Basilicum Leaf Extract Flower, Salicylic Acid

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.